Technical reference. Written for analysts and AI agents and kept in sync with the repository, so it uses internal terms. Raw Markdown: /pages/cause-research.md.
Cause research hub (research-only)
Public summary of Better World cause expansion research packs. These packs map evaluator anchors and open questions so humans can decide what (if anything) to ingest later.
Status (all packs below): research-ready, awaiting Ho Hum approval before any org ingest, draft promotion, or cause phase flip.
Hub date: 2026-10-01 (ET)
This page is not a ranking. Until Ho Hum explicitly approves ingest for a pack, agents and donors should treat these areas as bibliography / research context only — not Better World Top / Promising recommendations, and not inputs to /v1/recommend.
Live recommendations today remain Phase 1 global health (GiveWell life-saving + HLI wellbeing). See causes/global-health.md and evaluator-anchors.md.
JSON-LD sidecar: cause-research.jsonld.
Hard rules (agents and donors)
- Research only — no org ingest, no invented cost-effectiveness (CE), no outreach, no domain registration or spend from this tree.
- No ranking these packs until Ho Hum approves ingest for named orgs / funds / drafts.
- ADR 0007 is Proposed (awaiting Ho Hum) — separate leaderboards per outcome family; agents must not invent WELLBY↔life↔SAD↔tCO₂e conversion factors.
- Prefer evaluator funds and qualitative framing over invented portable CE in expansion areas.
Methodology: docs/methodology.md · ranking rules: docs/methodology-ranking.md · moral weights (Proposed): docs/methodology-moral-weights.md
Red lines: docs/red-lines-and-exceptions.md · donor FAQ: faq-donors.md
Operator approval desk (internal index): docs/cause-research-index.md
Research packs (96 on live disk; 90 at 0.2.15 cut; prior 83 at 0.2.14; 78 at 0.2.13; 68 at 0.2.12)
| Cause | Primary evaluator(s) | What the pack covers | Explicitly not done |
|---|---|---|---|
| Animal welfare | ACE (primary); related: EA Animal Welfare Fund, Rethink Priorities welfare ranges, Ambitious Impact SADs | ACE Recommended Charities landscape; giving vehicles (e.g. ACE RCF); units often in SADs / animals helped — separate from human lives-saved | No animal-welfare org ingest; no live ranking; no SADs↔lives conversion |
| Climate | Giving Green; Founders Pledge Climate Change Fund; GWWC overview (climate not currently on GWWC recs) | Top Climate Nonprofits / funds; $/tCO₂e bars as quoted heuristics only (never Better World CE); SRM governance out of gift options | No climate org/fund ingest; no live climate recommendations |
| US policy / advocacy | Coefficient Giving / Open Philanthropy (Abundance & Growth); Founders Pledge (evidence-based / evaluating policy) | Leverage of policy philanthropy; why portable CE is often missing; tax/lobbying disclosure needs | No policy org ingest; never auto-rank policy $ vs GiveWell $/life |
| Mental health / wellbeing (expansion) | HLI (primary); Happier Lives Fund; GiveWell as contrast only | Expansion beyond Phase 1 HLI Top/Promising already live (StrongMinds, Friendship Bench, Pure Earth, Taimaka, HLF) | No new orgs; Honourable Mentions / pipeline stay bibliography until approval |
| Depression / CMD treatment-gap | WHO (depression; mhGAP; MH Action Plan); GiveWell — no dedicated mhGAP/CMD-systems CEA / Top Charity (honest thin-evidence); HLI context (WELLBY stays MH); IHME/Lancet MAT ~9.1% | Maps systems treatment-gap (mhGAP PHC; essential psychotropics; WHO brief manuals) complementary to MH HLI Shamiri/ACTRA pack; cross-links MH (no charity CE duplicate) + epilepsy (mhGAP epilepsy-module) + pain | No org ingest; drafts CE null / not_for_ranking; cause_depression_treatment_gap future-only; no WELLBY↔DALY mixes; no medical dosing |
| Autism / NDD support & early identification | WHO (autism fact sheet ~1 in 127/2021; CST; WHO–UNICEF Global report; WHA67.8); GiveWell — no dedicated autism/NDD/CST CEA (honest null); IHME/Lancet Psychiatry GBD 2021; no cure | Maps LMIC early identification / developmental monitoring, caregiver skills training access (WHO CST shape), rights-based inclusion / service access; cross-links MH (no Shamiri/ACTRA/IPT duplicate) + depression (no mhGAP-depression duplicate) + epilepsy (no AED duplicate) | No org ingest; drafts CE null / not_for_ranking; cause_autism_ndd future-only; no behavioural-therapy protocols; no cure framing |
| Dementia / Alzheimer / cognitive ageing | WHO (dementia fact sheet 57M/2021 >60% LMIC; iSupport; Global action plan →2031; GDO); GiveWell — no dedicated dementia CEA / Top Charity (honest null); IHME/GBD ADOD; no cure | Maps LMIC caregiver support, diagnosis access, thin systems/action-plan themes; cross-links depression (no mhGAP depression duplicate) + stroke (no acute-care duplicate) + falls/ageing + pain (no morphine) + MH (no IPT/FB) | No org ingest; drafts CE null / not_for_ranking; cause_dementia future-only; no disease-modifying CE / cure claims; no medical dosing |
| GCR / x-risk | Founders Pledge GCR Fund; Longview; GWWC Risks & Resilience; Coefficient bio/AI/GCR funds (bibliography); 80k framing | Funds-first orientation; high-level themes only; info-hazard care (no dual-use detail) | No org ingest; no CE / risk-probability BOTE as verified claims; never convert GCR $ → lives_saved |
| Lead / education | HLI (Pure Earth Ghana cosmetics — already live); GiveWell Pure Earth incubation paths; Founders Pledge (LEEP paint; TaRL / Imagine education) | Maps live Pure Earth vs candidates (LEEP, spice/RMS pathways, education orgs) | No new orgs (do not duplicate Pure Earth); education cause stays future-only until approval |
| Family planning / reproductive health | GiveWell (valuing contraception + mobile outreach + FP grants); Founders Pledge (FEM); GWWC (FEM not currently recommended) | Maps evaluator landscape (mobile outreach, commodity supply, mass-media informed-choice); sensitive-topic: no medical advice; voluntary / informed-choice framing | No org ingest; draft CE null; quarantine units-of-value / ×-benchmark quotes; cause_family_planning future-only |
| Air quality (HAP / cookstoves) | GiveWell (clean cookstoves interim; All Grants footnotes illustrative only); WHO HAP; Berkeley Air / HAP M&E; Clean Cooking Alliance (named on GW); CATF climate-overlap only | Health-first household air pollution vs climate pack; clean-fuel preference given GW RCT skepticism; usage/exposure M&E bar before any CE | No org ingest; draft CE null; no double-count with climate; quarantine ~6× cash footnote as non-BW CE; cause_air_quality future-only |
| Poverty / cash / income (expansion) | GiveWell (Cash for Poverty Relief + pilots); GiveDirectly; HLI cash WELLBY benchmark (already live) | Maps live GiveDirectly / int_cash vs GiveWell CE update and 2025–2026 program-variation pilots (supply-side, targeting, cash+bridges) + other GD lines |
No new orgs (do not duplicate GiveDirectly); drafts CE null / not_for_ranking; no cause_income |
| Safe water / sanitation (expansion) | GiveWell (water quality + 2025–2026 pilots + DSW monitoring); Evidence Action Safe Water updates; WHO/JMP/GLAAS burden | Maps live Evidence Action / int_chlorination vs ILC multi-country pilots, high-burden DSW, vouchers/filters/spring protection, thin sanitation/hygiene |
No new orgs (do not duplicate Evidence Action Safe Water/ILC); drafts CE null / not_for_ranking; no cause_sanitation |
| Deworming / NTD (expansion) | GiveWell (combination deworming + Aug 2022 criteria + recent grants); Evidence Action DtW; WHO PC (bibliography) | Maps live DtW / Unlimit Health / Sightsavers / int_deworming vs exit/surveillance, high-burden MDA, WHO 2022 schisto targeting, community STH, END Fund bibliography, thin other-NTD |
No new orgs (do not duplicate DtW/SCI/Sightsavers; no END Fund ingest); drafts CE null / not_for_ranking; former-top vs current stance flagged |
| Schistosomiasis (bilharzia) | WHO (fact sheet ~253.7M needing PC 2024; 2022 guideline; NTD road map); GiveWell — dated schisto MDA + combination deworming (cite-only; DCP2 $/DALY quarantined); IHME GBD/GHDx | Maps no live schisto-only interventions vs PZQ PC/MDA (WHO 2022), snail control, water-contact WASH/behaviour; complementary to Wave BW deworming (no END Fund/STH/combination CE duplicate); cross-links water (chlorination ≠ snail/WASH) + skin-NTD + anaemia | No org ingest (do not duplicate DtW/Unlimit/Sightsavers; no END Fund); drafts CE null / not_for_ranking; cause_schistosomiasis future-only; no medical dosing |
| Schisto morbidity / FGS / FSAC systems | WHO (genital-manifestations ~56M FGS; Pocket Atlas; simultaneous-screening; fact sheet); GiveWell — dated schisto MDA cite-only (Wave ER) + FGS/FSAC systems honest null; IHME GBD | Maps no live FGS/FSAC systems interventions vs FGS clinical recognition, SRH–HIV–cervical integration, morbidity–WASH–snail systems; complementary to Wave ER (no dual CE; MDA/PC + snail/WASH stay ER); cross-links deworming + water (chlorination ≠ snail/WASH) + HIV/syphilis/cervical | No org ingest (Sightsavers deworming-only; no Merck/END Fund/FIG); drafts CE null / not_for_ranking; cause_schisto_morbidity future-only; no medical dosing / lesion how-to |
| Lymphatic filariasis / onchocerciasis | WHO (LF ~657M needing PC; MMDP; GPELF; oncho ~252.3M needing PC 2024; ≥80% coverage; NTD road map); GiveWell — dated LF + river-blindness MDA (cite-only; DCP2 $/DALY quarantined); IHME GBD | Maps no live LF/oncho interventions vs LF MDA, thin MMDP, oncho ivermectin MDA; complementary to Wave BW deworming (no END Fund/STH/combination CE duplicate); cross-links vision (trachoma ≠ oncho) + skin-NTD + schisto + Wave FZ MMDP systems | No org ingest (do not duplicate DtW/Unlimit/Sightsavers; no Carter Center/END Fund/Merck); drafts CE null / not_for_ranking; cause_lf_onchocerciasis future-only; no medical dosing |
| LF MMDP / hydrocele / lymphedema systems | WHO (MMDP ~40M manifestations; minimum package; 2019 surgical approaches; GPELF progress); GiveWell — dated LF MDA cite-only (Wave EV) + MMDP systems honest null; IHME GBD | Maps no live MMDP systems interventions vs hydrocele surgery access, lymphoedema care access, facility readiness / patient estimation; complementary to Wave EV (no dual CE; MDA/elimination stay EV); cross-links deworming + skin/leprosy/Buruli + trachoma (TT ≠ hydrocele) | No org ingest (Sightsavers deworming-only; no Carter Center/END Fund); drafts CE null / not_for_ranking; cause_lf_mmdp future-only; no medical dosing / surgical how-to |
| LF MDA / transmission interruption programme systems | WHO (GPELF MDA; fact sheet; progress 2024; monitoring manual 2025 TAS/EMS/IDA/PVS; GHO); GiveWell — dated LF MDA cite-only (Wave EV thin int_lf_mda) + LF MDA Top Charity / refreshed CEA honest null; IHME GBD |
Maps no live LF-MDA-systems interventions vs campaign delivery & coverage, TAS/stop-MDA/surveillance, IDA/persistent-transmission remediation; complementary to Wave EV (no dual CE; thin int_lf_mda stays EV); Wave FZ MMDP ≠ MDA; Wave GB oncho ≠ LF MDA; no dual CE with deworming |
No org ingest (Sightsavers deworming-only; no Carter Center/END Fund); drafts CE null / not_for_ranking; cause_lf_mda future-only; no medical dosing / IDA regimen how-to |
| Nutrition / micronutrient fortification (expansion) | GiveWell (Helen Keller VAS Top Charity; iron fortification; IFA / rice; Africa anemia RFI; MMS study); HLI (Taimaka / Fortify Health — already live) | Maps live VAS / wheat fortification / CMAM / EA IFA org vs salt iodization, maternal MMS, rice fortification, Africa iron RFI, school-age IFA | No new orgs (do not duplicate Helen Keller / Fortify Health / EA IFA / Taimaka); drafts CE null / not_for_ranking; no cause_fortification |
| Anaemia / iron deficiency (LMIC multi-etiology) | WHO (fact sheet Feb 2025; accelerating framework; 2025 estimates); GiveWell iron fortification/IFA/Africa RFI/podcast (cite-only — nutrition owns CE); IHME/GBD | Maps no live anaemia-specific cause vs etiology surveillance, malaria/helminth co-driver pathways, maternal anaemia pathway shape; cross-links nutrition (no IFA/fortification/MMS/VAS duplicate) + maternal + malaria (no ITN/SMC) + deworming (no MDA) + sickle | No org ingest; drafts CE null / not_for_ranking; cause_anemia future-only; no medical dosing |
| Iodine deficiency / USI / goiter | WHO (salt-iodization guideline; IDD assessment/monitoring guide; systematic review); GiveWell salt iodization (cite-only — nutrition owns manufacturer draft); IHME/GBD | Maps no live iodine-specific cause vs UIC/goiter surveillance, USI quality/coverage systems, residual severe-pocket supplementation shape; cross-links nutrition (no VAS/IFA/MMS/iron/salt-iodization-draft duplicate) + anaemia (stay separate) + hypertension (salt-CVD stays HTN) | No org ingest (do not duplicate IGN); drafts CE null / not_for_ranking; cause_iodine_deficiency future-only; no medical dosing |
| Vitamin D deficiency / nutritional rickets | WHO (2025 oils/fats vitamins A+D fortification guideline; 2019 nutritional rickets review — not a guideline; eLENA infants further-research / 404 at build); GiveWell — no dedicated VDD/rickets CEA / Top Charity (honest null; VAS cite-only A≠D — nutrition owns); IHME/GBD thin dedicated-row honesty | Maps no live VDD/rickets interventions vs 25(OH)D/rickets surveillance, oil/fat vitamin D fortification systems, infant/maternal supplementation shape (LMIC pediatric+maternal); cross-links nutrition (no VAS/IFA/MMS/iron/iodization-draft duplicate) + anaemia + iodine (stay separate) + maternal (no EmONC) + osteoporosis/falls (adult stays ED) | No org ingest; drafts CE null / not_for_ranking; cause_vitamin_d_rickets future-only; no medical dosing |
| Immunization / vaccines (expansion) | GiveWell (New Incentives Top Charity; vaccines strategy; IRD/Suvita; Mar 2026 outreach RFI; measles SIAs; HPV); Gavi bibliography-only | Maps live New Incentives / int_cci (+ related PATH malaria vaccine TA) vs IRD mCCT, SMS reminders, targeted outreach, measles SIAs, HPV drafts |
No new orgs (do not duplicate New Incentives / PATH / MC; no IRD / Suvita / Gavi ingest); drafts CE null / not_for_ranking; controversies flagged |
| Malaria (ITNs / SMC / seasonal expansion) | GiveWell (AMF ITNs + Malaria Consortium SMC Top Charities — already live; PATH vaccine/PMC grants; IRS thin) | Maps live AMF / MC / thin vaccine TA vs PMC, IRS, and RTS,S/R21 bibliography-only | No new orgs (do not duplicate AMF / MC / PATH); drafts CE null / not_for_ranking; vaccines bibliography-only; no cause_vector_control |
| Tuberculosis (TB) | GiveWell (TB HCM / TPT–IPT; mass screen-and-treat ACF; CHAI/Spiro grants bibliography; TB CEA cells bibliography-only) | Maps no live TB orgs/interventions vs ACF + IPT/TPT drafts; disambiguates live int_group_ipt (mental health) |
No TB org ingest; drafts CE null / not_for_ranking; cause_tuberculosis future-only; cells bibliography-only |
| HIV / AIDS | GiveWell (oral PrEP; VMMC; ART / treatment support — interim reports; 2025–26 aid-cut reassessment; HIV CEA cells bibliography-only) | Maps no live HIV orgs/interventions vs PrEP, VMMC, ART/treatment-support drafts; cells bibliography-only; sensitive-topic (no medical advice) | No HIV org ingest; drafts CE null / not_for_ranking; cause_hiv future-only; cells bibliography-only; do not duplicate immunization HPV |
| Diarrhea / ORS / cholera | GiveWell (ORS/zinc report; CHAI Bauchi / Clear Solutions / NI ORSZ; JHU CHoBI7; ORS/zinc CEA cells bibliography-only); WHO burden | Maps no live ORS intervention vs free ORS+zinc, mass/door-to-door, SMC layering, immunization co-delivery, thin OCV, CHoBI7/PICHA7; cross-links live water chlorination + org_new_incentives_ors (no duplicates) |
No new orgs (do not duplicate NI-ORS / EA water; no CHAI/Clear Solutions/JHU ingest); drafts CE null / not_for_ranking; cause_diarrhea future-only; cells bibliography-only |
| Childhood pneumonia / ARI | GiveWell (iCCM interim; R4D amox-DT grants + lookback; new-areas oxygen/pulse-ox; iCCM + R4D CEA cells bibliography-only); WHO / IHME LRI burden | Maps no live pneumonia treatment interventions vs pulse oximetry, medical oxygen access, community case management of pneumonia, pediatric amoxicillin-DT access; cross-links immunization PCV/Hib (int_cci) — no vaccine CE duplicate; HAP stays air-quality; diarrhea/ORS separate |
No new orgs (no R4D/IRC/PATH oxygen-arm; do not duplicate NI); drafts CE null / not_for_ranking; cause_pneumonia future-only; cells bibliography-only |
| Neonatal sepsis / SBI care systems | GiveWell — no dedicated PSBI/neonatal-sepsis treatment CEA (honest null); CHX cord care cite-only (preliminary cells quarantine); WHO SBI 2024 + PSBI referral-not-feasible | Maps no live neonatal-sepsis interventions vs PSBI outpatient systems, facility SBI care access, CHX cord care; complementary to maternal (no EmONC CE duplicate) + pneumonia (no childhood amox/iCCM/oxygen CE duplicate); cross-links meningitis + syphilis | No org ingest; drafts CE null / not_for_ranking; cause_neonatal_sepsis future-only; no medical dosing |
| Postpartum sepsis / maternal infection IPC systems | GiveWell — no dedicated postpartum-sepsis / maternal-sepsis CEA (honest null beyond facility MNH infection-prevention component cites — maternal owns); WHO peripartum infections 2015 + Statement on Maternal Sepsis + APT-Sepsis Nov 2025 | Maps no live postpartum-sepsis interventions vs facility maternity IPC, early-recognition/response (FAST-M shape), infection referral/care-access; complementary to maternal (no EmONC CE duplicate) + PPH + neonatal sepsis + syphilis | No org ingest; drafts CE null / not_for_ranking; cause_postpartum_sepsis future-only; no medical dosing |
| Preterm birth / ACS care systems | GiveWell — no dedicated ACS / preterm-birth CEA / Top Charity (honest null beyond facility MNH component cites); WHO ACS 2022 + preterm fact sheet | Maps no live ACS interventions vs ACS access / preterm referral / facility readiness; cross-links maternal (no EmONC/ACS/KMC duplicate) + neonatal sepsis + Wave FL stillbirth + PPH + preeclampsia + obstructed labor | No org ingest; drafts CE null / not_for_ranking; cause_preterm_birth future-only; no medical dosing |
| Stillbirth / perinatal mortality prevention systems | GiveWell — no dedicated stillbirth / MPDSR CEA (honest null); facility/community/PLA stillbirth outcomes maternal-owned cite-only; WHO MPDSR / ENAP / ICD-PM / Labour Care Guide | Maps no live stillbirth interventions vs surveillance/response, intrapartum prevention systems, antepartum risk/ANC systems; complementary to maternal (no EmONC/package CE duplicate) + PPH + PE + neonatal sepsis + fistula + OL + syphilis | No org ingest; drafts CE null / not_for_ranking; cause_stillbirth future-only; no medical dosing |
| Pain / palliative care | HLI (Pain Exploration 3; 2020/2023 pain reports; 2025 Giving Season — Pallium in progress); GiveWell bibliography-only/N/A | Maps no live pain orgs/interventions vs palliative opioid-access systems, thin MSK PT, hypothetical psychotherapy-for-pain; HLI Pallium BOTECs bibliography-only; cross-link MH int_mh_palliative_care_access |
No pain org ingest; drafts CE null / not_for_ranking; cause_pain_palliative future-only; BOTECs bibliography-only; no medical advice; do not duplicate MH palliative stub |
| Hypertension / cardiovascular | GiveWell (dietary salt modification Jul 2025; community salt substitution; nutrition strategy CVD H2; PH-regulation sodium vs lead); WHO HEARTS/burden bibliography | Maps no live hypertension interventions vs dietary salt modification, potassium salt-substitute scale-up, community substitution, thin antihypertensive/HEARTS access, sodium policy; cross-links live Pure Earth (lead) + air-quality HAP CVD burden (no duplicates); GiveWell dietary-salt/community-salt CEA cells + Pure Earth/lead vs hypertension-meds cells bibliography-only | No new orgs (do not duplicate Pure Earth; no RTSL/WASH ingest); drafts CE null / not_for_ranking; cause_hypertension future-only; cells bibliography-only |
| Diabetes / metabolic NCD | WHO (fact sheet; Compact; HEARTS-D; interventions brief); IHME/Lancet GBD diabetes; GiveWell context only (nutrition H2 SSB; NCD Best Buys PDF — no deep diabetes CEA) | Maps no live diabetes interventions vs T2 prevention, metformin/insulin LMIC access, foot care, retinopathy screening, thin SSB/diet advocacy; cross-links hypertension (no salt-sub duplicate) + air-quality HAP→CVD (stay air-quality) + vision (cataract/trachoma separate); WHO Best Buys / GBD figures bibliography-only | No new orgs; drafts CE null / not_for_ranking; cause_diabetes future-only; cells bibliography-only; ADR 0007 Proposed (no mid-age NCD↔under-5 mix) |
| Glaucoma / diabetic retinopathy | WHO (blindness/vision fact sheet; glaucoma ~7.7M / DR ~3.9M; World report on vision / IPEC; diabetes brief D2); GiveWell — no dedicated glaucoma/DR CEA (honest null; cataract/SAFE cite-only — vision owns); IHME/VLEG/GBD | Maps no live glaucoma/DR interventions vs glaucoma case-finding + treatment access, DR sight-threatening treatment access, thin IPEC systems (LMIC beyond trachoma/cataract); cross-links vision (no SAFE/cataract duplicate) + diabetes (glycemic CE + screening stub stay diabetes) | No org ingest; drafts CE null / not_for_ranking; cause_glaucoma_retinopathy future-only; WHO 411B bibliography-only; no medical dosing/laser protocols |
| Hepatitis B / C | WHO (HepB/HepC/blood-safety fact sheets; Global hepatitis report 2026); GiveWell (NI pentavalent + indirect HepB BD — vaccine CE cross-link only; no dedicated Hep CEA); Gavi bibliography-only | Maps no live hepatitis interventions vs HepB birth-dose coverage gap, testing & treatment access (HCV DAAs bibliography), blood/injection safety; cross-links immunization int_cci (no duplicate vaccine CE) + HIV co-infection notes only |
No org ingest (no Gavi/CHAI/Unitaid); drafts CE null / not_for_ranking; cause_hepatitis future-only; no medical advice |
| Cirrhosis / chronic liver disease | WHO (HepB/HepC — cirrhosis/HCC pathway; Global hepatitis report 2026; alcohol liver-disease co-driver; no dedicated cirrhosis fact sheet); GiveWell — no dedicated cirrhosis/CLD CEA / Top Charity (honest thin-evidence); IHME/GBD 2021 | Maps no live cirrhosis interventions vs CLD care access, viral hepatitis sequelae linkage, alcohol co-driver themes (LMIC); cross-links hepatitis (no HepB-BD/DAA duplicate) + alcohol-tobacco (no SAFER/RESET duplicate) + immunization | No org ingest; drafts CE null / not_for_ranking; cause_cirrhosis future-only; no medical protocols |
| Pandemic / biosecurity preparedness | Coefficient Biosecurity & Pandemic Preparedness; Founders Pledge biosecurity / GCBR / GCR Fund; GWWC Risks & Resilience; 80k framing | Maps no live biosecurity orgs/interventions vs pathogen-agnostic PPE policy, early detection capacity, Far-UVC/GUV themes, governance/norms, fund vehicles; cross-link GCR thin biosecurity stub | No biosecurity org ingest; drafts CE null / not_for_ranking; cause_pandemic_preparedness future-only; info-hazard high-level only (no dual-use); do not duplicate GCR stub |
| Road safety / traffic injury | GiveWell (Zusha! standout — discontinued; incubation; 2017 blog; 2009 DCP speed/speed-bumps pointer; 2019 AIP Helmets for Kids — not selected; Zusha! CEA cells bibliography-only); WHO fact sheet + Global status 2023; IHME GBD | Maps no live road-safety interventions vs speed enforcement, speed bumps, motorcycle/child helmets, drink-drive enforcement, thin trauma/post-crash care, Zusha!-class speak-up stickers; cross-links maternal (no obstetric trauma duplicate) + lead + air (stay separate) | No new orgs (no gui2de/Zusha!/AIP); drafts CE null / not_for_ranking; cause_road_safety future-only; cells bibliography-only |
| Drowning / child water safety | WHO (fact sheet; Guideline day-care + swim skills strong recommendations; practical guidance); IHME GBD Results; GiveWell — no dedicated drowning CEA | Maps no live drowning interventions vs daycare/creche supervision, basic swim/water-safety skills, barriers (wells/doorways/playpens/fencing); cross-links road-safety trauma + safe-water/WASH diarrhoea (stay separate); WHO investment-case cost-saving bibliography-only | No new orgs (no CIPRB/SwimSafe/Bloomberg drowning); drafts CE null / not_for_ranking; cause_drowning future-only; no invented CE |
| Snakebite envenoming | WHO (fact sheet; 2019 strategy; antivenoms); GiveWell (Dec 2022 open-thread — 2017 below-bar unpublished; bibliography-only); IHME Nature Comm 2022 | Maps no live snakebite interventions vs antivenom access, community first-response (no clinical how-to), thin health-systems case management; cross-links skin-NTD + deworming/other-NTD (snakebite ≠ MDA/PC ≠ skin-NTD) | No org ingest (no Wellcome/MSF/GSI; do not expand Sightsavers); drafts CE null / not_for_ranking; cause_snakebite future-only; no medical advice |
| Postpartum hemorrhage (PPH) care systems; obstetric fistula | GiveWell (fistula surgery Dec 2021 — below funding bar; BOTE bibliography-only); WHO (facts-in-pictures; guiding principles) | Maps no live fistula interventions vs surgical repair access + prevention via timely C-section / obstructed-labor care; cross-links maternal (thin int_mn_fistula_repair; no EmONC CE duplicate) |
No org ingest (no Fistula Foundation/Hamlin/EngenderHealth); drafts CE null / not_for_ranking; cause_fistula future-only; no medical advice |
| Sickle cell disease | WHO (fact sheet; childhood guideline; AFRO strategy/PEN-Plus); GiveWell — no dedicated SCD CEA / Top Charity (honest thin-evidence); IHME GBD 2021 | Maps no live SCD interventions vs newborn screening, penicillin prophylaxis, hydroxyurea access, transfusion/malaria co-management (high level); cross-links malaria (no ITN/SMC/PMC CE duplicate) + maternal + immunization (PCV/Hib) | No org ingest; drafts CE null / not_for_ranking; cause_sickle_cell future-only; no medical advice |
| Noma / severe oral-facial gangrene & oral health | WHO (fact sheet; Dec 2023 NTD listing; oral-health co-mention); GiveWell — no dedicated noma CEA / Top Charity (honest thin-evidence); IHME/GBD noma not computed | Maps no live noma interventions vs early detection/acute care, nutrition co-factors, reconstructive surgery access (LMIC); cross-links nutrition (no VAS/CMAM CE duplicate) + skin-NTD (platform only) + maternal/fistula (no EmONC duplicate) | No org ingest; drafts CE null / not_for_ranking; cause_noma future-only; WHO 1998 burden bibliography-only; no medical advice |
| Leprosy (Hansen’s disease) | WHO (fact sheet ~200k new cases/year; Global Leprosy Strategy 2021–2030; free MDT; contact screening); GiveWell — no dedicated leprosy CEA (honest null); IHME GBD bibliography | Maps no live leprosy interventions vs ACD/contact screening, MDT access & continuity, disability prevention / stigma–rehab; complementary to Wave CS skin-NTD (no scabies/yaws MDA or thin int_skin_ntd_leprosy_* duplicate); cross-links noma + schisto + LF/oncho + deworming |
No org ingest (no ILEP/Lepra/Leprosy Mission; Sightsavers deworming-only); drafts CE null / not_for_ranking; cause_leprosy future-only; no medical dosing |
| Human African trypanosomiasis (HAT / sleeping sickness) | WHO (HAT fact sheet; GHO; EOT verification; Chagas disambiguation); GiveWell — no dedicated HAT CEA (honest null); IHME GBD bibliography | Maps no live HAT interventions vs screening & treatment access, tsetse vector-control systems, elimination/surveillance; Wave FC owns Chagas (T. cruzi ≠ T. brucei); complementary to Wave FA VL (sandfly ≠ tsetse); cross-links LF/oncho + schisto + skin-NTD + leprosy + deworming | No org ingest (no DNDi/MSF/FIND; Sightsavers deworming-only); drafts CE null / not_for_ranking; cause_hat future-only; no medical dosing |
| Chagas disease (American trypanosomiasis) | WHO (fact sheet ~8M infected; >10k deaths/yr; vector/congenital/blood screening; NTD road map); GiveWell — no dedicated Chagas CEA (honest null); IHME GBD bibliography | Maps no live Chagas interventions vs vector-control systems, screening & treatment access, congenital/blood–organ screening; complementary to Wave FA VL (Chagas ≠ VL) + LF/schisto/skin-NTD/leprosy/deworming; cross-links RHD/IHD (cardiomyopathy ≠ RHD ≠ IHD) | No org ingest (no DNDi/MSF/Mundo Sano; Sightsavers deworming-only); drafts CE null / not_for_ranking; cause_chagas future-only; no medical dosing |
| Buruli ulcer (Mycobacterium ulcerans) | WHO (fact sheet ≥33 countries; early detection + antibiotics; GHO; skin-NTD framework); GiveWell — no dedicated Buruli CEA (honest null); IHME GBD bibliography | Maps no live Buruli interventions vs case-finding, treatment-access & lab confirmation, disability / wound–lymphoedema / rehab; complementary to Wave CS skin-NTD (no scabies/yaws MDA or thin int_skin_ntd_other_buruli_cl_mycetoma duplicate); cross-links leprosy + noma + LF/oncho + VL + deworming |
No org ingest (no ALM/Anesvad/FIND; Sightsavers deworming-only); drafts CE null / not_for_ranking; cause_buruli_ulcer future-only; no medical dosing |
| Yaws (T. pallidum subsp. pertenue) | WHO (fact sheet ~15 endemic countries; Morges TCT + surveillance; eradication criteria; skin-NTD framework); GiveWell — no dedicated yaws CEA (honest null); IHME GBD bibliography | Maps no live yaws interventions vs case-finding, MDA/TCT access & coverage, post-MDA surveillance; complementary to Wave CS skin-NTD (keep thin int_skin_ntd_yaws_azithromycin_morges; no dual CE); cross-links Buruli + CL + leprosy + vision/trachoma + deworming; mycetoma thin CS only |
No org ingest (no EMS/yaws NGOs; Sightsavers deworming-only); drafts CE null / not_for_ranking; cause_yaws future-only; no medical dosing |
| Scabies (Sarcoptes scabiei) | WHO (fact sheet ≥200M; MDA ≥10%; UHC targets; crusted/outbreak; skin-NTD framework); GiveWell — Sep 2021 MDA cite-only (CEA cells Wave CS; below-bar) + systems honest null; IHME GBD bibliography | Maps no live scabies systems interventions vs MDA-access/delivery, case-management/household access, crusted-outbreak systems; complementary to Wave CS skin-NTD (keep thin int_skin_ntd_scabies_ivermectin_mda; no dual CE); cross-links yaws + Buruli + CL + leprosy + mycetoma + deworming |
No org ingest (no WSEP; Sightsavers deworming-only); drafts CE null / not_for_ranking; cause_scabies future-only; no medical dosing |
| —. Acute poisoning / toxic exposures — No live poisoning interventions. GiveWell CPSP cite-only + honest null acute unintentional CEA; WHO poison centres / pesticides / HAP kerosene-ingestion; LEEP stays lead. Cross-link snakebite (no dual CE) + burns (ingestion ≠ flame) + road-safety. Info-hazard high-level only. No medical dosing. | |||
| Acute poisoning / toxic exposures | WHO (poison centres; pesticides; household pesticides; HAP kerosene-ingestion); GiveWell — CPSP cite-only + honest null acute unintentional CEA; LEEP stays lead; IHME GBD bibliography | Maps no live poisoning interventions vs HHP regulation systems, paraffin ingestion prevention, household safe-storage, poison-centre capacity; cross-links lead (LEEP) + snakebite (no dual CE) + burns (ingestion ≠ flame) + road-safety | No org ingest; drafts CE null / not_for_ranking; cause_poisoning future-only; info-hazard high-level only; no medical dosing |
| Oral health beyond noma (caries / periodontal / fluoride) | WHO (oral-health fact sheet ~3.7B; untreated permanent caries most common GBD 2021; >1B severe periodontal; Global status report + strategy/GOHAP 2023–2030); GiveWell — no dedicated oral-health / fluoride / caries CEA / Top Charity (honest thin-evidence); IHME/Lancet GBD 2021 oral conditions | Maps no live oral-health interventions vs caries prevention/care access, periodontal care + tobacco co-factor systems, PHC/UHC oral-health integration (LMIC); fluoride water/salt/toothpaste bibliography-only (no dosing); complementary to Wave DS noma (no noma draft duplicate); cross-links nutrition (iodization ≠ fluoridation) + water (chlorination ≠ fluoridation) + alcohol-tobacco (no MPOWER duplicate) + diabetes (no metabolic duplicate) | No org ingest; drafts CE null / not_for_ranking; cause_oral_health future-only; no medical/fluoride dosing |
| COPD exacerbation / chronic respiratory care pathway | WHO (COPD fact sheet — flare-ups/oxygen/rehab; rehab Module 4); GiveWell — no dedicated COPD-exacerbation / pulmonary-rehab / LTOT CEA / Top Charity (honest thin-evidence); IHME/GBD 2021 | Maps no live pathway interventions vs LMIC exacerbation care systems, pulmonary rehab access, chronic/long-term oxygen (adult CRD); complementary to Wave DX (no inhaler/PEN duplicate); cross-links pneumonia (no childhood oxygen) + air-quality (no HAP CE) + alcohol-tobacco (no MPOWER) | No org ingest; drafts CE null / not_for_ranking; cause_copd_exacerbation future-only; no medical dosing |
| Asthma / COPD / CRD | WHO (asthma + COPD fact sheets; CRD topic; PEN); GiveWell — no dedicated asthma/COPD / inhaler CEA / Top Charity (honest thin-evidence); IHME/GBD 2021 | Maps no live CRD interventions vs inhaler access, PEN primary-care CRD, prevention/exposure themes (HAP + tobacco cross-link only); cross-links air-quality (no HAP CE duplicate) + alcohol-tobacco (no MPOWER duplicate) + pneumonia (no amox-DT duplicate) | No org ingest; drafts CE null / not_for_ranking; cause_asthma_copd future-only; no medical dosing |
| Epilepsy / seizure disorders | WHO (fact sheet; IGAP 2022–2031; mhGAP-IG epilepsy module; technical brief); GiveWell — no dedicated epilepsy / phenobarbital CEA / Top Charity (honest thin-evidence); IHME/Lancet Public Health GBD 2021 | Maps no live epilepsy interventions vs ASM/phenobarbital access, mhGAP primary-care integration, thin stigma/care-seeking (LMIC treatment gap); cross-links mental-health (no IPT duplicate) + pain/palliative (no morphine draft duplicate) | No org ingest; drafts CE null / not_for_ranking; cause_epilepsy future-only; no medical advice / ASM dosing |
| Meningitis / meningococcal disease | WHO (fact sheet; Defeating Meningitis by 2030; AFRO belt; MenAfriVac/Men5CV shape); GiveWell Meningitis A (2016) — RFMF-stop / incomplete investigation (honest thin-evidence; no completed CEA/Top Charity); IHME/GBD 2023 | Maps no live meningitis interventions vs belt epidemic surveillance & outbreak response, diagnosis/treatment care access, post-meningitis sequelae support (LMIC); cross-links immunization (PCV/Hib/MenA/Men5CV — no vaccine CE duplicate) + hearing-loss (sequelae notes only) | No org ingest; drafts CE null / not_for_ranking; cause_meningitis future-only; GW RFMF-stop bibliography-only; no medical advice |
| MenA / meningococcal conjugate vaccine systems | WHO (fact sheet; Jan 2024 MMCV belt position paper; Defeating Meningitis); GiveWell — dedicated MenA Top Charity / completed CEA honest null (Jan 2016 RFMF-stop cite-only); IHME/GBD; Gavi meningococcal bibliography (Wave BZ owns Gavi) | Maps no live MenA systems interventions vs MenAfriVac/MenA mass-campaign, Men5CV/MMCV introduction, MenA/Men5CV routine–catch-up systems; complementary to Wave DU meningitis (belt/care/sequelae stay meningitis; no dual CE) + Wave BZ immunization (no dual routine-EPI CE); Hib ≠ MenA; PCV ≠ MenA | No org ingest; drafts CE null / not_for_ranking; cause_meningococcal future-only; no medical dosing |
| Malaria SMC / seasonal chemoprevention systems | WHO (fact sheet; guidelines; SMC field guide 2nd ed.; WMR 2024); GiveWell — SMC Top Charity cite by reference only (live int_smc); IHME/GBD |
Maps SMC systems deepen vs live malaria Top Charity CE: campaign delivery & coverage, geographic expansion & seasonal targeting, related chemoprevention (IPTp + IPTsc/PDMC adjacency); complementary to live cause_malaria (no dual CE; Wave BY PMC/IRS stay malaria); pneumonia/maternal adjacency |
No org ingest; drafts CE null / not_for_ranking; cause_malaria_smc future-only; no medical dosing |
| IPTp / malaria in pregnancy systems | WHO (Guidelines for malaria; Jun 2022 chemoprevention; Jan 2024 c-IPTp; WMR/GHO IPTp3); GiveWell — IPTp Top Charity honest null (preliminary CEA quarantine); IHME/GBD | Maps no live IPTp interventions vs IPTp-SP ANC delivery/coverage, community c-IPTp, MiP/ANC integration; complementary to live malaria (no dual ITN/SMC CE) + Wave HT childhood SMC (SMC ≠ IPTp) + Wave CB maternal (no dual EmONC CE) | No org ingest; drafts CE null / not_for_ranking; cause_malaria_iptp future-only; no medical dosing |
| Malaria IRS / indoor residual spray systems | WHO (fact sheet ITNs+IRS; guidelines; IRS operational manual Feb 2024; IRM; WMR); GiveWell — AMF/ITN cite by reference only (IRS Top Charity honest null); IHME/GBD | Maps IRS systems deepen vs live malaria ITN CE: campaign delivery & coverage, IRM, ITN↔IRS prioritization; complementary to live malaria (no dual CE; Wave BY thin IRS stay malaria) + HT SMC ≠ IRS + HV IPTp ≠ IRS | No org ingest; drafts CE null / not_for_ranking; cause_malaria_irs future-only; no pesticide how-to |
| PMC / perennial malaria chemoprevention systems | WHO (Guidelines for malaria; Jun 2022 chemoprevention — IPTi→PMC; fact sheet; WMR); GiveWell — PMC Top Charity honest null (PATH DRC pilot grant CEA quarantine); IHME/GBD | Maps no live PMC-systems interventions vs EPI-platform delivery/coverage, geographic/age-group expansion, programme integration/scale-up M&E; complementary to live malaria (no dual ITN/SMC CE; Wave BY thin int_malaria_pmc stay malaria) + Wave HT SMC (SMC ≠ PMC) + Wave HV IPTp (IPTp ≠ PMC) + Wave IA IRS (IRS ≠ PMC) |
No org ingest; drafts CE null / not_for_ranking; cause_malaria_pmc future-only; no medical dosing |
| IPTi / intermittent preventive treatment in infants systems | WHO (Guidelines for malaria; Jun 2022 chemoprevention — IPTi→PMC; fact sheet; WMR); GiveWell — IPTi Top Charity honest null (interim preliminary CEA quarantine); IHME/GBD | Maps no live IPTi-systems interventions vs EPI-contact delivery, coverage/supervision, surveillance–targeting; complementary to live malaria (no dual ITN/SMC CE) + Wave IB PMC (sibling; no dual CE) + Wave HT SMC (SMC ≠ IPTi) + Wave HV IPTp (IPTp ≠ IPTi) + Wave IN CM (CM ≠ prevention) | No org ingest; drafts CE null / not_for_ranking; cause_malaria_ipti future-only; no medical dosing |
| Malaria MDA / mass screening-and-treatment programme systems | WHO (fact sheet; guidelines MDA family; elimination recommendations; role-of-MDA/MSAT note; WMR); GiveWell — AMF/ITN + MC/SMC cite by reference only (MDA Top Charity / dedicated CEA honest null); IHME/GBD | Maps no live MDA-systems interventions vs elimination-setting MDA campaigns, outbreak/reactive MDA, MSAT/screening-linked programmes; complementary to live malaria (no dual ITN/SMC CE) + Wave HT SMC (SMC ≠ MDA) + Wave HV IPTp (IPTp ≠ MDA) + Wave IB PMC (PMC ≠ MDA) + Wave IR IPTi (IPTi ≠ MDA) + Wave IN CM (CM ≠ MDA) | No org ingest; drafts CE null / not_for_ranking; cause_malaria_mda future-only; no medical dosing |
| Malaria IPTsc / school-age chemoprevention systems | WHO (fact sheet; guidelines IPTsc family; Jun 2022; preventive-chemotherapies; WMR); GiveWell — AMF/ITN + MC/SMC cite by reference only (IPTsc Top Charity / dedicated CEA honest null); IHME/GBD | Maps no live IPTsc-systems interventions vs school-platform delivery, coverage/equity/alternative channels, surveillance-targeting / under-5 complementarity; complementary to live malaria (no dual ITN/SMC CE) + Wave HT SMC (SMC ≠ IPTsc) + Wave HV IPTp (IPTp ≠ IPTsc) + Wave IB PMC (PMC ≠ IPTsc) + Wave IR IPTi (IPTi ≠ IPTsc) + Wave IU MDA (MDA ≠ IPTsc) + Wave IN CM (CM ≠ prevention) | No org ingest; drafts CE null / not_for_ranking; cause_malaria_iptsc future-only; no medical dosing |
| Malaria RACD / reactive case detection systems | WHO (fact sheet; guidelines; elimination RACDT/RDA; WMR); GiveWell — AMF/ITN + MC/SMC cite by reference only (RACD Top Charity / dedicated CEA honest null); IHME/GBD | Maps no live RACD-systems interventions vs RACDT, reactive surveillance/case investigation, RDA (≠ mass MDA); complementary to live malaria (no dual ITN/SMC CE) + Wave IU MDA (mass ≠ reactive) + Wave IN CM (care ≠ reactive detection) | No org ingest; drafts CE null / not_for_ranking; cause_malaria_racd future-only; no medical dosing |
| Japanese encephalitis / arboviral encephalitis vaccine systems | WHO (fact sheet; IVB; 2015 position paper); GiveWell — JE CEA honest null; Gavi JE portfolio bibliography (Wave BZ owns Gavi) | Maps no live JE interventions vs vaccine introduction, catch-up campaigns, AEFI surveillance systems; complementary to Wave BZ immunization (no dual routine-EPI CE); cross-links meningitis (≠ bacterial) + pandemic; cross-link dengue/YF sibling packs | No org ingest (no Gavi/PATH/Chengdu; NI immunization-only); drafts CE null / not_for_ranking; cause_japanese_encephalitis future-only; no medical dosing |
| Measles SIAs / outbreak response systems | WHO (fact sheet; MRSF; SIA field guide; GMRLN; 2024/2025 burden news); GiveWell — measles-SIA Top Charity honest null (SIA intervention report cross-link/quarantine); IHME/GBD; Gavi measles/MR portfolio bibliography (Wave BZ owns Gavi) | Maps no live measles systems interventions vs preventive SIA campaigns, outbreak response immunization, surveillance/lab-access systems; complementary to Wave BZ immunization (no dual routine-EPI CE; thin measles-SIA draft stays immunization); cross-links meningitis (≠ bacterial) + pandemic + YF/cholera sibling campaigns | No org ingest (no Gavi/UNICEF/M&RP; NI immunization-only); drafts CE null / not_for_ranking; cause_measles future-only; no medical dosing |
| Rubella / CRS systems | WHO (fact sheet; position paper; Sep 2024 SAGE; CRS surveillance standards; MRSF/GMRLN); GiveWell — rubella/CRS Top Charity/CEA honest null; IHME/GBD; Gavi measles/MR portfolio bibliography (Wave BZ owns Gavi) | Maps no live rubella/CRS systems interventions vs RCV introduction, CRS surveillance programme-access, lab/case-based surveillance; complementary to Wave BZ immunization (no dual routine-EPI CE) + Wave GY measles (≠ measles SIAs); cross-links chik/Zika (CRS ≠ CZS) + maternal (programme only) | No org ingest; drafts CE null / not_for_ranking; cause_rubella future-only; no medical dosing / pregnancy clinical how-to |
| Polio / nOPV / cVDPV systems | WHO (fact sheet; strategy 2022–2026; nOPV2 PQ news; transition); GiveWell — polio Top Charity / CEA honest null (2016 vaccines blog incomplete-CEA cross-link/quarantine); IHME/GBD; Gavi IPV + GPEI strategy/GPLN bibliography (Wave BZ owns Gavi) | Maps no live polio systems interventions vs nOPV2 outbreak-response, endemic WPV campaigns, AFP/ES + GPLN lab-access systems; complementary to Wave BZ immunization (no dual routine-EPI CE; IPV-in-RI / NI OPV-IPV stay immunization); cross-links measles (sibling SIA ≠ polio) + meningitis (≠ bacterial) + pandemic/GCR PHEIC + YF/cholera sibling campaigns | No org ingest (no Gavi/UNICEF/Rotary/GPEI; NI immunization-only); drafts CE null / not_for_ranking; cause_polio future-only; no medical dosing |
| Rotavirus vaccine (RVV) systems | WHO (fact sheet; IVB; July 2021 position paper); GiveWell — dedicated RVV CEA / Top Charity honest null (NI rotavirus indirect cells stay Wave BZ); IHME/GBD; Gavi rotavirus portfolio bibliography (Wave BZ owns Gavi) | Maps no live RVV systems interventions vs introduction, catch-up, cold-chain & surveillance systems; complementary to Wave CG diarrhea (ORS/zinc ≠ RVV) + Wave BZ immunization (no dual routine-EPI CE); cross-links cholera/typhoid enteric siblings + water WASH | No org ingest (no Gavi/UNICEF/PATH/manufacturers; NI immunization-only); drafts CE null / not_for_ranking; cause_rotavirus future-only; no medical dosing / clinical rehydration how-to |
| PCV / pneumococcal conjugate vaccine systems | WHO (Sep 2025/2019 position paper; IVB; standardization); GiveWell — dedicated PCV Top Charity / CEA honest null; IHME/GBD; Gavi pneumococcal bibliography (Wave BZ owns Gavi) | Maps no live PCV systems interventions vs PCV introduction, catch-up/coverage-recovery, pneumonia–meningitis programme systems; complementary to Wave BZ immunization (no dual routine-EPI CE; PCV CE stays immunization); PCV ≠ care (pneumonia case management stays Wave DB); Hib ≠ PCV; meningitis MenA ≠ PCV; sibling SIAs ≠ PCV intro | No org ingest (no Gavi/PATH/manufacturers; NI immunization-only); drafts CE null / not_for_ranking; cause_pcv future-only; no medical dosing |
| HPV vaccine introduction / catch-up / vaccination-pillar systems | WHO (Dec 2022 position; IVB; product-choice; elimination 90% vaccination pillar); GiveWell — no HPV Top Charity; Oct 2020 vaccine CEA stays immunization; delivery-systems CEA honest null; IHME/GBD; Gavi HPV bibliography (Wave BZ owns Gavi) | Maps no live HPV systems interventions vs HPV introduction, MAC catch-up/coverage-recovery, elimination vaccination-pillar systems; complementary to Wave BZ immunization (no dual CE; thin int_immunization_hpv stays immunization); HPV vaccine ≠ screening CE (Wave CX owns VIA/DNA/treatment); rubella ≠ HPV; childhood cancer ≠ cervical HPV programme |
No org ingest (no Gavi/PATH/CHAI/Jhpiego; NI immunization-only); drafts CE null / not_for_ranking; cause_hpv future-only; no medical dosing |
| Varicella (chickenpox) / VZV vaccine introduction & catch-up systems | WHO (Nov 2025 position; June 2014 historical; IVB; VPD surveillance); GiveWell — varicella Top Charity/CEA honest null; IHME/GBD; Gavi portfolio — varicella not listed (Wave BZ owns Gavi) | Maps no live varicella systems interventions vs introduction/routine, catch-up/SIA-like, surveillance–AEFI systems; complementary to Wave BZ immunization (no dual EPI CE); measles ≠ varicella; rubella/CRS ≠ varicella; MMRV bibliography only; zoster ≠ childhood varicella | No org ingest; drafts CE null / not_for_ranking; cause_varicella future-only; no medical dosing |
| Hepatitis A (HAV) vaccine introduction / catch-up / outbreak systems | WHO (Oct 2022 position; fact sheet; outbreak toolbox; VPD HepA); GiveWell — HepA Top Charity/CEA honest null; IHME/GBD; Gavi portfolio — HepA not listed (VIS 2018 deprioritised; Wave BZ owns Gavi) | Maps no live HepA systems interventions vs introduction/routine, catch-up/outbreak, foodborne/sanitation-adjacent systems; complementary to Wave BZ immunization (no dual EPI CE); HepB ≠ HepA; HepC ≠ HepA; WASH CE stays water; ORS ≠ HepA vaccine | No org ingest; drafts CE null / not_for_ranking; cause_hepatitis_a future-only; no medical dosing |
| Seasonal influenza vaccine / programme systems | WHO (May 2022 SAGE position; Global Influenza Strategy 2019–2030; toolkit; GISRS); GiveWell — seasonal influenza Top Charity/CEA honest null; IHME/GBD; Gavi portfolio — seasonal flu not current listed window (Wave BZ owns Gavi) | Maps no live seasonal-flu systems interventions vs risk-group routine, campaign/delivery, surveillance–vaccine-match systems; complementary to Wave BZ immunization (no dual EPI CE); seasonal ≠ pandemic; pneumonia care ≠ flu vaccine | No org ingest; drafts CE null / not_for_ranking; cause_influenza future-only; no medical dosing; no dual-use |
| Hepatitis E vaccine / outbreak-response programme systems | WHO/SAGE (May 2015 position; March 2024 SAGE FCV WCBA; fact sheet; outbreak toolbox; 2014 waterborne); GiveWell — HepE Top Charity/CEA honest null; IHME/GBD; Gavi VIS 2024 HepE stockpile bibliography (Wave BZ owns Gavi) | Maps no live HepE systems interventions vs outbreak-campaign, pregnancy/WCBA targeting, WASH-adjacent surveillance systems; complementary to Wave BZ immunization (no dual EPI CE); HepA ≠ HepE; HepB ≠ HepE; HepC ≠ HepE; WASH CE stays water; ORS ≠ HepE vaccine; cholera OCV/ICG ≠ HepE | No org ingest; drafts CE null / not_for_ranking; cause_hepatitis_e future-only; no medical dosing |
| Hepatitis D / HDV co-infection programme systems | WHO (HepD fact sheet; 2024 CHB guidelines HDV who/how/reflex; Global hepatitis report 2024); GiveWell — HepD Top Charity/CEA honest null; HLI/ACE honest null; IHME/GBD | Maps no live HepD systems interventions vs HBsAg+ co-infection testing, reflex diagnosis-access, dual B+D programme shape; complementary to Waves DC/HN HepB (HepB ≠ HepD; birth-dose CE stays HN); HepC ≠ HepD; HepA ≠ HepD; HepE ≠ HepD; Wave BZ immunization (no dual EPI CE) | No org ingest; drafts CE null / not_for_ranking; cause_hepatitis_d future-only; no medical dosing |
| RSV maternal vaccine / long-acting mAb programme systems | WHO (May 2025 position; SAGE Sep 2024; 30 May 2025 news); GiveWell — RSV Top Charity/CEA honest null; IHME/GBD; Gavi RSV maternal design-phase bibliography (Wave BZ owns Gavi) | Maps no live RSV prevention systems interventions vs maternal-vaccine introduction, long-acting mAb delivery, surveillance–targeting systems; complementary to Wave BZ immunization (no dual EPI CE); pneumonia care ≠ RSV prevention; maternal EmONC ≠ RSV products; preterm ACS ≠ RSV; influenza ≠ RSV | No org ingest; drafts CE null / not_for_ranking; cause_rsv future-only; no medical dosing |
| Mumps vaccine introduction / catch-up / outbreak response systems | WHO (March 2024 position; IVB; VPD surveillance); GiveWell — mumps Top Charity/CEA honest null; IHME/GBD; Gavi portfolio — mumps/MMR not listed (measles/MR ≠ MMR; Wave BZ owns Gavi) | Maps no live mumps systems interventions vs introduction/routine, catch-up/outbreak, surveillance–orchitis/complication systems; complementary to Wave BZ immunization (no dual EPI CE); measles ≠ mumps; rubella/CRS ≠ mumps; varicella ≠ mumps; MMR/MMRV bibliography only | No org ingest; drafts CE null / not_for_ranking; cause_mumps future-only; no medical dosing |
| Seasonal influenza vaccine / programme systems | WHO (May 2022 SAGE position; Global Influenza Strategy 2019–2030; toolkit; GISRS); GiveWell — seasonal influenza Top Charity/CEA honest null; IHME/GBD; Gavi portfolio — seasonal flu not current listed window (Wave BZ owns Gavi) | Maps no live seasonal-flu systems interventions vs risk-group routine, campaign/delivery, surveillance–vaccine-match systems; complementary to Wave BZ immunization (no dual EPI CE); seasonal ≠ pandemic; pneumonia care ≠ flu vaccine | No org ingest; drafts CE null / not_for_ranking; cause_influenza future-only; no medical dosing; no dual-use |
| Maternal / neonatal tetanus (MNT) elimination systems | WHO (MNTE strategies/progress; tetanus fact sheet; WER9206; Protecting-all); GiveWell — MNT Top Charity honest null; intervention report + UNICEF MNTE declined-review quarantine; IHME/GBD; Gavi TTCV adjacency bibliography (Wave BZ owns Gavi) | Maps no live MNT systems interventions vs Td-SIA HRD, clean delivery/cord, NT surveillance/validation; complementary to Wave BZ immunization (no dual routine Td/TT EPI CE) + Wave CB maternal (no dual EmONC CE); Wave FI neonatal sepsis sibling adjacency | No org ingest; drafts CE null / not_for_ranking; cause_maternal_neonatal_tetanus future-only; no medical dosing |
| Pertussis (whooping cough) vaccine / outbreak systems | WHO/SAGE (health topic; WER9035; SAGE WG; IVB; GHO); GiveWell — pertussis Top Charity/CEA honest null (NI Penta incidental Wave BZ); IHME/GBD; Gavi pentavalent/hexavalent/DTP-booster bibliography (Wave BZ owns Gavi) | Maps no live pertussis systems interventions vs primary-series intro/schedule-strengthening, booster/coverage catch-up, outbreak response campaign systems; complementary to Wave BZ immunization (no dual EPI CE; DTP–Penta stays immunization); cross-links MNT (≠ aP/wP) + Hib (Penta adjacency) + PCV/pneumonia (≠ pertussis vaccine) | No org ingest (no Gavi/manufacturers; NI immunization-only); drafts CE null / not_for_ranking; cause_pertussis future-only; no medical dosing |
| Diphtheria vaccine / antitoxin programme systems | WHO/SAGE (fact sheet; Aug 2017 position paper; IVB; AFRO outbreak guidance; DAT access/stockpile programme framing); GiveWell — dedicated diphtheria Top Charity / CEA honest null; IHME/GBD; Gavi penta/DTP-booster bibliography (Wave BZ owns Gavi) | Maps no live diphtheria systems interventions vs primary/booster introduction, outbreak campaign, DAT access/stockpile programme systems; complementary to Wave BZ immunization (no dual routine-EPI CE; DTP–Penta CE stays immunization); MNT ≠ diphtheria (Wave HR); pertussis ≠ diphtheria (Wave IO); Hib ≠ diphtheria systems (Wave HD) | No org ingest (no Gavi/DAT manufacturers; NI immunization-only); drafts CE null / not_for_ranking; cause_diphtheria future-only; no medical dosing / antitoxin reconstitution |
| Childhood / adolescent / adult tetanus toxoid booster systems (beyond MNT) | WHO/SAGE (fact sheet; WER9206; Protecting-all; IVB; MNTE strategies sustain); GiveWell — childhood-tetanus Top Charity/CEA honest null (NI Penta incidental Wave BZ; MNT report Wave HR quarantine); IHME/GBD; Gavi DTP-booster bibliography (Wave BZ owns Gavi) | Maps no live childhood-tetanus booster systems vs childhood booster introduction, school-age/adolescent catch-up, injury-prone adult booster programme systems; complementary to Wave HR MNT (MNT ≠ childhood/adolescent/adult boosters) + Wave BZ immunization (no dual EPI CE; DTP–Penta stays immunization); pertussis ≠ tetanus boosters; diphtheria ≠ tetanus childhood boosters | No org ingest (no Gavi/manufacturers; NI immunization-only); drafts CE null / not_for_ranking; cause_tetanus_childhood future-only; no medical dosing / wound-care how-to |
| Hib conjugate vaccine systems | WHO (position paper; IVB; standardization); GiveWell — dedicated Hib Top Charity / CEA honest null; IHME/GBD; Gavi pentavalent bibliography (Wave BZ owns Gavi) | Maps no live Hib systems interventions vs Hib conjugate introduction, catch-up/coverage-recovery, meningitis–pneumonia programme systems; complementary to Wave BZ immunization (no dual routine-EPI CE; Penta/Hib CE stays immunization); Hib ≠ PCV (pneumonia case management stays Wave DB); meningitis MenA ≠ Hib; measles/polio SIAs ≠ Hib intro | No org ingest (no Gavi/Hib Initiative; NI immunization-only); drafts CE null / not_for_ranking; cause_hib future-only; no medical dosing |
| Cholera / oral cholera vaccine (OCV) systems | WHO (fact sheet; ICG cholera stockpile; GTFCC Ending Cholera 2030); GiveWell — cholera/OCV CEA honest null; IHME/GBD; Gavi OCV portfolio bibliography (Wave BZ owns Gavi) | Maps no live cholera systems interventions vs OCV preventive campaigns, ICG emergency stockpile, outbreak surveillance systems; complementary to Wave CG diarrhea (no dual ORS/zinc / thin OCV CE); cross-links water (broader WASH) + immunization (OCV ≠ EPI CE) + YF (sibling ICG) + pandemic | No org ingest (no Gavi/UNICEF/MSF/IFRC/GTFCC); drafts CE null / not_for_ranking; cause_cholera future-only; no medical dosing |
| Typhoid / typhoid conjugate vaccine (TCV) systems | WHO (fact sheet; IVB; position papers; 2018 news); GiveWell — typhoid/TCV CEA honest null; IHME/GBD; Gavi TCV portfolio bibliography (Wave BZ owns Gavi) | Maps no live typhoid systems interventions vs TCV introduction, catch-up campaigns, outbreak-response systems; complementary to Wave CG diarrhea (ORS/zinc ≠ TCV) + Wave GV cholera (OCV ≠ TCV); cross-links immunization (no dual EPI CE) + water (WASH) + YF/JE + pandemic | No org ingest (no Gavi/UNICEF/TyVAC); drafts CE null / not_for_ranking; cause_typhoid future-only; no medical dosing |
| Yellow fever vaccine / outbreak response systems | WHO (fact sheet; IVB; EYE; ICG guidelines); GiveWell — YF CEA honest null; IHME/GBD; Gavi YF portfolio bibliography (Wave BZ owns Gavi) | Maps no live YF interventions vs vaccine introduction, PMVC, ICG emergency stockpile systems; complementary to Wave BZ immunization (no dual routine-EPI CE); cross-links JE (≠ YF) + dengue (owns Aedes IVM) + meningitis (≠ bacterial) + pandemic | No org ingest (no Gavi/UNICEF/MSF/IFRC; NI immunization-only); drafts CE null / not_for_ranking; cause_yellow_fever future-only; no medical dosing |
| Dengue fever / Aedes-borne systems | WHO (fact sheet; vaccines Q&A; May 2024 position; TAK-003 PQ; GVCR/GAI); GiveWell — dengue CEA honest null; Gavi VIS bibliography (Wave BZ owns Gavi); IHME/GBD | docs/cause-dengue-research.md |
No new orgs; drafts CE null; complementary to JE (≠ dengue) + malaria (Anopheles ≠ Aedes) + immunization (no dual EPI CE); cross-link YF (Wave GQ) + chik/Zika (Wave GT); dengue keeps Aedes IVM; no medical dosing / vector-engineering SOPs |
| Chikungunya / Zika Aedes-sibling systems | WHO (chikungunya + Zika fact sheets; GAI); GiveWell — chik/Zika CEA honest null; IHME/GBD | docs/cause-chikungunya-zika-research.md |
No new orgs; drafts CE null; combined cause_chikungunya_zika future; complementary to dengue (owns Aedes IVM), YF (≠ chik/Zika), JE (Culex ≠ Aedes), immunization (no dual EPI CE); no medical dosing / pregnancy clinical how-to / vector-engineering SOPs |
| Rabies PEP / dog vaccination systems (human rabies / One Health) | WHO (fact sheet; Zero by 30; UAR; NTD roadmap); GiveWell — rabies CEA honest null; IHME/GBD bibliography; Gavi PEP support bibliography (Wave BZ owns Gavi) | Maps no live rabies interventions vs PEP access/readiness, dog MDV coverage, integrated bite-case surveillance; complementary to Wave BZ immunization (no dual routine-EPI CE; dog MDV ≠ human EPI CE); cross-links snakebite (antivenom ≠ RIG/PEP) + animal welfare (ACE ≠ human elimination) + pandemic (zoonosis only) | No org ingest (no Gavi/UAR/GARC; NI immunization-only; no ACE ingest); drafts CE null / not_for_ranking; cause_rabies future-only; no PEP regimen / dosing how-to |
| Hearing loss / ear & hearing care | WHO (fact sheet; World Report on Hearing 2021; H.E.A.R.I.N.G.); GiveWell — no dedicated hearing CEA / Top Charity (honest thin-evidence); IHME/Lancet GBD 2019 YLDs | Maps no live hearing interventions vs childhood/newborn screening, chronic otitis media sequelae, hearing-aids access, adult occupational conservation (LMIC); cross-links immunization (PCV/Hib — no vaccine CE duplicate) + pain/palliative (no palliative draft duplicate) | No org ingest; drafts CE null / not_for_ranking; cause_hearing_loss future-only; WHO ROI bibliography-only; no medical advice |
| Chronic kidney disease / dialysis access | WHO (fact sheet ~674M; WHA78.6 kidney health); GiveWell — no dedicated CKD/dialysis CEA / Top Charity (honest thin-evidence); IHME/Lancet GBD 2023 | Maps no live CKD interventions vs PHC early detection/case-finding, dialysis/KRT access, transplant + conservative care (LMIC); cross-links hypertension (no salt-sub duplicate) + diabetes (no draft duplicate) + pain (conservative QoL only) | No org ingest; drafts CE null / not_for_ranking; cause_kidney_disease future-only; WHO vs GBD prevalence quarantined; no medical advice |
| Childhood cancer | WHO (fact sheet; GICC ≥60% by 2030; CureAll framework); GiveWell — no dedicated childhood-cancer CEA / Top Charity (honest thin-evidence); IHME/GBD childhood-cancer DALYs | Maps no live childhood-cancer interventions vs early diagnosis/referral, essential medicines & treatment access, CureAll/GICC programme strengthening (LMIC); cross-links pain/palliative (no morphine draft duplicate); disambiguates cervical HPV / immunization HPV vaccine | No org ingest; drafts CE null / not_for_ranking; cause_childhood_cancer future-only; WHO cost-effective language quarantined; no medical advice / chemo protocols |
| Stroke / cerebrovascular disease | WHO (fact sheet; ACS–stroke framework 2024; HEARTS); GiveWell — no dedicated stroke / thrombolysis CEA / Top Charity (honest thin-evidence); adjacent GW salt pages stay HTN bibliography; IHME/GBD 2021 | Maps no live stroke interventions vs HTN-control prevention pathway shape, acute care & thrombolysis access, rehab/secondary-prevention access (LMIC); cross-links hypertension (no salt-sub duplicate) + diabetes + alcohol/tobacco (no MPOWER duplicate) + air-quality HAP | No org ingest; drafts CE null / not_for_ranking; cause_stroke future-only; no medical advice / thrombolysis protocols |
| Ischemic heart disease / AMI / ACS | WHO (heart-attack fact sheet IHD ~9M/2021; CVD fact sheet; ACS–stroke framework 2024; HEARTS); GiveWell — no dedicated IHD/AMI/ACS CEA / Top Charity (honest thin-evidence); adjacent GW salt pages stay HTN bibliography; IHME/GBD | Maps no live IHD interventions vs ACS/AMI acute-care access, post-ACS secondary-prevention & cardiac-rehab access, HEARTS primary pathway shape (LMIC); cross-links hypertension (no salt-sub duplicate) + stroke (no thrombolysis duplicate) + diabetes + RHD + CHD | No org ingest; drafts CE null / not_for_ranking; cause_ischemic_heart_disease future-only; no medical advice / PCI protocols |
| Burns / thermal injury | WHO (burns fact sheet; safer cookstoves/lamps; strengthen burn care; 2008 plan); GiveWell — no dedicated burns CEA / Top Charity (honest thin-evidence; clean cookstoves = HAP — air-quality owns); IHME/GBD burns bibliography | Maps no live burns interventions vs safer cookstoves/lamps (burn-injury prevention), first-aid access themes (no how-to), reconstructive care access; cross-links air-quality (no HAP CE duplicate) + road-safety trauma + pain/palliative | No org ingest; drafts CE null / not_for_ranking; cause_burns future-only; no medical advice / no first-aid how-to |
| Osteoporosis / falls / fragility fracture | WHO (falls ~684k/>80% LMIC; fragility fractures 2019; ageing & Decade/ICOPE); GiveWell — no dedicated falls/osteoporosis CEA / Top Charity (honest thin-evidence); IHME/GBD | Maps no live falls/osteo interventions vs older-adult fall prevention, fragility-fracture/bone-health access, LMIC ageing systems themes; cross-links road-safety (no trauma/Zusha duplicate) + burns + drowning + hypertension (fall-risk meds bibliography only) | No org ingest; drafts CE null / not_for_ranking; cause_osteoporosis_falls future-only; no medical dosing |
| Rheumatic heart disease / ARF | WHO (fact sheet; 2024 guideline; WHA71.14); GiveWell — no dedicated RHD CEA; IHME/NEJM GBD 2015 | Maps no live RHD interventions vs secondary prophylaxis (BPG), GAS pharyngitis primary prevention, thin valve-surgery access; cross-links hypertension (no salt-sub), maternal/fistula (no EmONC), syphilis (BPG commodity only) | No org ingest; drafts CE null / not_for_ranking; cause_rheumatic_heart future-only; no medical advice |
| Acute rheumatic fever (ARF) primary prevention | WHO (RHD fact sheet; 2024 guideline; WHA71.14); GiveWell — no dedicated ARF primary-prevention CEA (honest null); IHME/GBD | Maps no live ARF primary interventions vs school/community sore-throat systems, primordial living/housing, first-episode recognition/surveillance; complementary to Wave DM RHD (keep secondary/thin GAS/valve; no dual CE); cross-links IHD + CHD | No org ingest; drafts CE null / not_for_ranking; cause_rheumatic_fever future-only (or fold under RHD); no medical dosing |
Wave FU (folded into 0.2.13): Trachoma SAFE systems research pack — docs/cause-trachoma-research.md · future cause_trachoma (complementary to vision ranking themes; CE null drafts; Sightsavers deworming-only).
Wave GG (folded into 0.2.14): Schisto morbidity / FGS / FSAC systems research pack — docs/cause-schisto-morbidity-research.md · future cause_schisto_morbidity (complementary to Wave ER MDA/PC ownership; CE null drafts; no dual CE).
Wave GD (folded into 0.2.14): Postpartum sepsis / maternal infection IPC systems research pack — docs/cause-postpartum-sepsis-research.md · future cause_postpartum_sepsis (complementary to maternal EmONC ownership; CE null drafts; no dual CE with PPH/neonatal/syphilis).
Wave GB (folded into 0.2.14): Onchocerciasis systems research pack — docs/cause-onchocerciasis-research.md · future cause_onchocerciasis (complementary to Wave EV LF/oncho MDA/elimination; CE null drafts; Sightsavers deworming-only; no dual CE with LF MDA).
Wave GE (folded into 0.2.14): Thalassaemia / haemoglobinopathy systems research pack — docs/cause-thalassemia-research.md · future cause_thalassemia (complementary to sickle + anaemia; CE null drafts; GiveWell honest null; no dual CE with SCD NBS/transfusion; no chelation dosing).
Wave GI (folded into 0.2.15): Hepatitis C (HCV) treatment-access / DAA scale-up research pack — docs/cause-hepatitis-c-research.md · future cause_hepatitis_c (complementary to Wave DC hepatitis; CE null drafts; GiveWell honest null; no dual CE with HepB-BD / combined testing-treatment / blood-safety or cirrhosis; no DAA regimens as how-to).
Wave GN (folded into 0.2.15): Rabies PEP / dog vaccination systems research pack — docs/cause-rabies-research.md · future cause_rabies (complementary to Wave BZ + snakebite + animal welfare; CE null drafts; no dual EPI CE; no PEP how-to).
Wave GT (folded into 0.2.15): Chikungunya / Zika Aedes-sibling systems — docs/cause-chikungunya-zika-research.md · future cause_chikungunya_zika.
Wave GM (folded into 0.2.15): Dengue / Aedes systems — docs/cause-dengue-research.md · future cause_dengue.
Wave GK (folded into 0.2.15): Japanese encephalitis / arboviral encephalitis vaccine systems research pack — docs/cause-japanese-encephalitis-research.md · future cause_japanese_encephalitis (complementary to Wave BZ; CE null drafts; no dual EPI CE).
Wave GY (Unreleased post-0.2.15; QA pass landed): Measles SIAs / outbreak response systems research pack — docs/cause-measles-research.md · future cause_measles (complementary to Wave BZ; CE null drafts; no dual EPI CE).
Wave GV (folded into 0.2.15): Cholera / OCV systems research pack — docs/cause-cholera-research.md · future cause_cholera (complementary to Wave CG; CE null drafts; no dual ORS/thin OCV CE).
Wave GQ (folded into 0.2.15): Yellow fever vaccine / outbreak response systems research pack — docs/cause-yellow-fever-research.md · future cause_yellow_fever (complementary to Wave BZ; CE null drafts; no dual EPI CE).
Wave GW (Unreleased post-0.2.15; QA pass landed): Typhoid / TCV systems — docs/cause-typhoid-research.md · future cause_typhoid.
Wave HG (Unreleased post-0.2.15; QA pass landed): Rubella / CRS systems research pack — docs/cause-rubella-research.md · future cause_rubella (complementary to Wave BZ + Wave GY; CE null drafts; no dual EPI CE; CRS ≠ CZS).
Wave GZ (Unreleased): Polio / nOPV / cVDPV systems research pack — docs/cause-polio-research.md · future cause_polio (complementary to Wave BZ; CE null drafts; no dual EPI CE).
Wave HC (Unreleased post-0.2.15; QA pass landed): Rotavirus / RVV systems research pack — docs/cause-rotavirus-research.md · future cause_rotavirus (complementary to diarrhea ORS/zinc ≠ RVV + immunization; CE null drafts; no dual EPI CE).
Wave IB (Unreleased post-0.2.15; QA pass landed): PMC / perennial malaria chemoprevention systems research pack — docs/cause-malaria-pmc-research.md · future cause_malaria_pmc (complementary to live malaria + HT SMC + HV IPTp + IA IRS; CE null drafts; SMC ≠ PMC ≠ IPTp ≠ IRS; no dual ITN/SMC CE).
Wave IR (Unreleased post-0.2.15; QA pass landed): IPTi / intermittent preventive treatment in infants systems research pack — docs/cause-malaria-ipti-research.md · future cause_malaria_ipti (complementary to live malaria + Wave IB PMC sibling + HT SMC + HV IPTp + IN CM; CE null drafts; IPTi ≠ SMC ≠ IPTp ≠ CM; no dual ITN/SMC/PMC CE).
Wave IZ (Unreleased post-0.2.15; QA pass landed): LF MDA / transmission interruption programme systems research pack — docs/cause-lf-mda-research.md · future cause_lf_mda (complementary to Wave EV thin int_lf_mda + Wave FZ MMDP ≠ MDA + Wave GB oncho ≠ LF MDA; CE null drafts; no dual CE with deworming).
Wave IU (Unreleased post-0.2.15; QA pass landed): Malaria MDA / mass screening-and-treatment programme systems research pack — docs/cause-malaria-mda-research.md · future cause_malaria_mda (complementary to live malaria + HT SMC + HV IPTp + IB PMC + IR IPTi + IN CM; CE null drafts; MDA ≠ SMC ≠ IPTp ≠ PMC ≠ IPTi ≠ CM; no dual ITN/SMC CE).
Wave IX (Unreleased post-0.2.15; QA pass landed): Malaria IPTsc / school-age chemoprevention systems research pack — docs/cause-malaria-iptsc-research.md · future cause_malaria_iptsc (complementary to live malaria + HT SMC + HV IPTp + IB PMC + IR IPTi + IU MDA + IN CM; CE null drafts; IPTsc ≠ SMC ≠ IPTp ≠ PMC ≠ IPTi ≠ MDA ≠ CM; no dual ITN/SMC CE).
Wave JE (Unreleased post-0.2.15; QA pass landed): Malaria RACD / reactive case detection systems research pack — docs/cause-malaria-racd-research.md · future cause_malaria_racd (complementary to live malaria + IU MDA + IN CM + HT–IX chemoprevention + JB vivax; CE null drafts; RACD ≠ MDA mass ≠ CM care; no dual ITN/SMC CE).
Wave IA (Unreleased post-0.2.15; QA pass landed): IRS / indoor residual spray systems research pack — docs/cause-malaria-irs-research.md · future cause_malaria_irs (complementary to live malaria + HT SMC + HV IPTp; CE null drafts; SMC ≠ IRS ≠ IPTp; no dual ITN/SMC CE).
Wave HV (Unreleased post-0.2.15; QA pass landed): IPTp / malaria in pregnancy systems research pack — docs/cause-malaria-iptp-research.md · future cause_malaria_iptp (complementary to live malaria + Wave HT SMC; CE null drafts; SMC ≠ IPTp; no dual ITN/SMC/EmONC CE).
Wave HT (Unreleased post-0.2.15; QA pass landed): Malaria SMC / seasonal chemoprevention systems research pack — docs/cause-malaria-smc-research.md · future cause_malaria_smc (complementary to live malaria; CE null drafts; no dual SMC/ITN CE; pneumonia/maternal adjacency).
Wave HP (Unreleased post-0.2.15; QA pass landed): MenA / meningococcal conjugate vaccine systems research pack — docs/cause-meningococcal-research.md · future cause_meningococcal (complementary to Wave DU + Wave BZ; CE null drafts; no dual EPI CE; Hib ≠ MenA; PCV ≠ MenA).
Wave HK (Unreleased post-0.2.15; QA pass landed): PCV / pneumococcal conjugate vaccine systems research pack — docs/cause-pcv-research.md · future cause_pcv (complementary to Wave BZ; CE null drafts; no dual EPI CE; PCV ≠ care; Hib ≠ PCV).
Wave HL (Unreleased post-0.2.15; QA pass landed): HPV vaccine introduction / catch-up / vaccination-pillar systems research pack — docs/cause-hpv-research.md · future cause_hpv (complementary to Wave BZ + Wave CX; CE null drafts; no dual CE; HPV vaccine ≠ screening CE).
Wave IF (Unreleased post-0.2.15; QA pass landed): Varicella (chickenpox) / VZV vaccine introduction & catch-up systems research pack — docs/cause-varicella-research.md · future cause_varicella (complementary to Wave BZ + GY + HG; CE null drafts; no dual EPI CE; measles ≠ varicella; rubella ≠ varicella).
Wave II (Unreleased post-0.2.15; QA pass landed): Mumps vaccine introduction / catch-up / outbreak response systems research pack — docs/cause-mumps-research.md · future cause_mumps (complementary to Wave BZ + GY + HG + IF; CE null drafts; no dual EPI CE; measles ≠ mumps; rubella ≠ mumps; varicella ≠ mumps).
Wave IL (Unreleased post-0.2.15; QA pass landed): Hepatitis E vaccine / outbreak-response programme systems research pack — docs/cause-hepatitis-e-research.md · future cause_hepatitis_e (complementary to Wave BZ + IH + DC/HN + GI; CE null drafts; no dual EPI CE; HepA ≠ HepE; HepB ≠ HepE; HepC ≠ HepE; WASH CE stays water).
Wave JC (Unreleased post-0.2.15; QA pass landed): Hepatitis D / HDV co-infection programme systems research pack — docs/cause-hepatitis-d-research.md · future cause_hepatitis_d (complementary to DC/HN + GI + IH + IL + BZ; CE null drafts; HepB ≠ HepD; HepC ≠ HepD; HepA ≠ HepD; HepE ≠ HepD; no dual EPI CE).
Wave IK (Unreleased post-0.2.15; QA pass landed): RSV maternal vaccine / long-acting mAb programme systems research pack — docs/cause-rsv-research.md · future cause_rsv (complementary to Wave BZ + DB + CB + FH; CE null drafts; no dual EPI CE; care ≠ RSV prevention).
Wave IJ (Unreleased post-0.2.15; QA pass landed): Seasonal influenza vaccine / programme systems research pack — docs/cause-influenza-research.md · future cause_influenza (complementary to Wave BZ + CT + DB; CE null drafts; no dual EPI CE; seasonal ≠ pandemic; pneumonia care ≠ flu vaccine).
Wave IH (Unreleased post-0.2.15; QA pass landed): Hepatitis A (HAV) vaccine introduction / catch-up / outbreak systems research pack — docs/cause-hepatitis-a-research.md · future cause_hepatitis_a (complementary to Wave BZ + DC/HN + GI; CE null drafts; no dual EPI CE; HepB ≠ HepA; HepC ≠ HepA; WASH CE stays water).
Wave IJ (Unreleased post-0.2.15; QA pass landed): Seasonal influenza vaccine / programme systems research pack — docs/cause-influenza-research.md · future cause_influenza (complementary to Wave BZ + CT + DB; CE null drafts; no dual EPI CE; seasonal ≠ pandemic; pneumonia care ≠ flu vaccine).
Wave HR (Unreleased post-0.2.15; QA pass landed): Maternal / neonatal tetanus (MNT) elimination systems research pack — docs/cause-maternal-neonatal-tetanus-research.md · future cause_maternal_neonatal_tetanus (complementary to Wave BZ + Wave CB; CE null drafts; no dual EPI/EmONC CE).
Wave IO (Unreleased post-0.2.15; QA pass landed): Pertussis (whooping cough) vaccine / outbreak systems research pack — docs/cause-pertussis-research.md · future cause_pertussis (complementary to Wave BZ; CE null drafts; no dual EPI CE; MNT ≠ aP/wP).
Wave HD (Unreleased post-0.2.15; QA pass landed): Hib conjugate vaccine systems research pack — docs/cause-hib-research.md · future cause_hib (complementary to Wave BZ; CE null drafts; no dual EPI CE; Hib ≠ PCV).
Wave IP (Unreleased post-0.2.15; QA pass landed): Diphtheria vaccine / antitoxin programme systems research pack — docs/cause-diphtheria-research.md · future cause_diphtheria (complementary to Wave BZ; CE null drafts; no dual EPI CE; MNT ≠ diphtheria; pertussis ≠ diphtheria; Hib ≠ diphtheria systems).
Wave IS (Unreleased post-0.2.15; QA pass landed): Childhood / adolescent / adult tetanus toxoid booster systems beyond MNT research pack — docs/cause-tetanus-childhood-research.md · future cause_tetanus_childhood (complementary to Wave HR MNT + Wave BZ; CE null drafts; MNT ≠ childhood boosters; no dual EPI CE).