# Cause research hub (research-only)

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Public summary of Better World **cause expansion research packs**. These packs map evaluator anchors and open questions so humans can decide what (if anything) to ingest later.

**Status (all packs below):** research-ready, **awaiting Ho Hum approval** before any org ingest, draft promotion, or cause phase flip.  
**Hub date:** 2026-10-01 (ET)

**This page is not a ranking.** Until Ho Hum explicitly approves ingest for a pack, agents and donors should treat these areas as **bibliography / research context only** — not Better World Top / Promising recommendations, and not inputs to `/v1/recommend`.

Live recommendations today remain Phase 1 **global health** (GiveWell life-saving + HLI wellbeing). See [causes/global-health.md](causes/global-health.md) and [evaluator-anchors.md](evaluator-anchors.md).

JSON-LD sidecar: [cause-research.jsonld](cause-research.jsonld).

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## Hard rules (agents and donors)

- **Research only** — no org ingest, no invented cost-effectiveness (CE), no outreach, no domain registration or spend from this tree.
- **No ranking** these packs until Ho Hum approves ingest for named orgs / funds / drafts.
- **ADR 0007 is Proposed** (awaiting Ho Hum) — separate leaderboards per outcome family; agents must **not** invent WELLBY↔life↔SAD↔tCO₂e conversion factors.
- Prefer evaluator **funds** and qualitative framing over invented portable CE in expansion areas.

Methodology: [`docs/methodology.md`](../../docs/methodology.md) · ranking rules: [`docs/methodology-ranking.md`](../../docs/methodology-ranking.md) · moral weights (Proposed): [`docs/methodology-moral-weights.md`](../../docs/methodology-moral-weights.md)  
Red lines: [`docs/red-lines-and-exceptions.md`](../../docs/red-lines-and-exceptions.md) · donor FAQ: [faq-donors.md](faq-donors.md)

Operator approval desk (internal index): [`docs/cause-research-index.md`](../../docs/cause-research-index.md)

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## Research packs (**96** on live disk; **90** at **0.2.15** cut; prior **83** at **0.2.14**; **78** at **0.2.13**; **68** at **0.2.12**)

| Cause | Primary evaluator(s) | What the pack covers | Explicitly not done |
|-------|----------------------|----------------------|---------------------|
| **Animal welfare** | ACE (primary); related: EA Animal Welfare Fund, Rethink Priorities welfare ranges, Ambitious Impact SADs | ACE Recommended Charities landscape; giving vehicles (e.g. ACE RCF); units often in SADs / animals helped — separate from human lives-saved | No animal-welfare org ingest; no live ranking; no SADs↔lives conversion |
| **Climate** | Giving Green; Founders Pledge Climate Change Fund; GWWC overview (climate **not** currently on GWWC recs) | Top Climate Nonprofits / funds; $/tCO₂e bars as **quoted heuristics only** (never Better World CE); SRM governance out of gift options | No climate org/fund ingest; no live climate recommendations |
| **US policy / advocacy** | Coefficient Giving / Open Philanthropy (Abundance & Growth); Founders Pledge (evidence-based / evaluating policy) | Leverage of policy philanthropy; why portable CE is often missing; tax/lobbying disclosure needs | No policy org ingest; never auto-rank policy $ vs GiveWell $/life |
| **Mental health / wellbeing (expansion)** | HLI (primary); Happier Lives Fund; GiveWell as contrast only | Expansion **beyond** Phase 1 HLI Top/Promising already live (StrongMinds, Friendship Bench, Pure Earth, Taimaka, HLF) | **No new** orgs; Honourable Mentions / pipeline stay bibliography until approval |
| **Depression / CMD treatment-gap** | WHO (depression; mhGAP; MH Action Plan); GiveWell — **no** dedicated mhGAP/CMD-systems CEA / Top Charity (**honest thin-evidence**); HLI context (WELLBY stays MH); IHME/Lancet MAT ~9.1% | Maps **systems** treatment-gap (mhGAP PHC; essential psychotropics; WHO brief manuals) complementary to MH HLI Shamiri/ACTRA pack; **cross-links** MH (**no charity CE duplicate**) + epilepsy (mhGAP epilepsy-module) + pain | **No** org ingest; drafts CE null / not_for_ranking; `cause_depression_treatment_gap` future-only; no WELLBY↔DALY mixes; no medical dosing |
| **Autism / NDD support & early identification** | WHO (autism fact sheet ~1 in 127/2021; CST; WHO–UNICEF Global report; WHA67.8); GiveWell — **no** dedicated autism/NDD/CST CEA (**honest null**); IHME/Lancet Psychiatry GBD 2021; **no cure** | Maps **LMIC early identification / developmental monitoring**, **caregiver skills training access** (WHO CST shape), **rights-based inclusion / service access**; **cross-links** MH (**no Shamiri/ACTRA/IPT duplicate**) + depression (**no mhGAP-depression duplicate**) + epilepsy (**no AED duplicate**) | **No** org ingest; drafts CE null / not_for_ranking; `cause_autism_ndd` future-only; no behavioural-therapy protocols; no cure framing |
| **Dementia / Alzheimer / cognitive ageing** | WHO (dementia fact sheet 57M/2021 >60% LMIC; iSupport; Global action plan →2031; GDO); GiveWell — **no** dedicated dementia CEA / Top Charity (**honest null**); IHME/GBD ADOD; **no cure** | Maps **LMIC caregiver support**, **diagnosis access**, thin **systems/action-plan** themes; **cross-links** depression (**no mhGAP depression duplicate**) + stroke (**no acute-care duplicate**) + falls/ageing + pain (**no morphine**) + MH (**no IPT/FB**) | **No** org ingest; drafts CE null / not_for_ranking; `cause_dementia` future-only; no disease-modifying CE / cure claims; no medical dosing |
| **GCR / x-risk** | Founders Pledge GCR Fund; Longview; GWWC Risks & Resilience; Coefficient bio/AI/GCR funds (bibliography); 80k framing | Funds-first orientation; high-level themes only; **info-hazard** care (no dual-use detail) | No org ingest; no CE / risk-probability BOTE as verified claims; never convert GCR $ → lives_saved |
| **Lead / education** | HLI (Pure Earth Ghana cosmetics — **already live**); GiveWell Pure Earth incubation paths; Founders Pledge (LEEP paint; TaRL / Imagine education) | Maps live Pure Earth vs candidates (LEEP, spice/RMS pathways, education orgs) | **No new** orgs (do not duplicate Pure Earth); education cause stays future-only until approval |
| **Family planning / reproductive health** | GiveWell (valuing contraception + mobile outreach + FP grants); Founders Pledge (FEM); GWWC (FEM **not currently** recommended) | Maps evaluator landscape (mobile outreach, commodity supply, mass-media informed-choice); sensitive-topic: no medical advice; voluntary / informed-choice framing | No org ingest; draft CE null; quarantine units-of-value / ×-benchmark quotes; `cause_family_planning` future-only |
| **Air quality (HAP / cookstoves)** | GiveWell (clean cookstoves interim; All Grants footnotes illustrative only); WHO HAP; Berkeley Air / HAP M&E; Clean Cooking Alliance (named on GW); **CATF climate-overlap only** | Health-first household air pollution vs climate pack; clean-fuel preference given GW RCT skepticism; usage/exposure M&E bar before any CE | No org ingest; draft CE null; no double-count with climate; quarantine ~6× cash footnote as non-BW CE; `cause_air_quality` future-only |
| **Poverty / cash / income (expansion)** | GiveWell (Cash for Poverty Relief + pilots); GiveDirectly; HLI cash WELLBY benchmark (**already live**) | Maps live GiveDirectly / `int_cash` vs GiveWell CE update and 2025–2026 program-variation pilots (supply-side, targeting, cash+bridges) + other GD lines | **No new** orgs (do not duplicate GiveDirectly); drafts CE null / not_for_ranking; no `cause_income` |
| **Safe water / sanitation (expansion)** | GiveWell (water quality + 2025–2026 pilots + DSW monitoring); Evidence Action Safe Water updates; WHO/JMP/GLAAS burden | Maps live Evidence Action / `int_chlorination` vs ILC multi-country pilots, high-burden DSW, vouchers/filters/spring protection, thin sanitation/hygiene | **No new** orgs (do not duplicate Evidence Action Safe Water/ILC); drafts CE null / not_for_ranking; no `cause_sanitation` |
| **Deworming / NTD (expansion)** | GiveWell (combination deworming + Aug 2022 criteria + recent grants); Evidence Action DtW; WHO PC (bibliography) | Maps live DtW / Unlimit Health / Sightsavers / `int_deworming` vs exit/surveillance, high-burden MDA, WHO 2022 schisto targeting, community STH, END Fund bibliography, thin other-NTD | **No new** orgs (do not duplicate DtW/SCI/Sightsavers; no END Fund ingest); drafts CE null / not_for_ranking; former-top vs current stance flagged |
| **Schistosomiasis (bilharzia)** | WHO (fact sheet ~253.7M needing PC 2024; 2022 guideline; NTD road map); GiveWell — dated schisto MDA + combination deworming (**cite-only**; DCP2 $/DALY quarantined); IHME GBD/GHDx | Maps **no live schisto-only interventions** vs PZQ PC/MDA (WHO 2022), snail control, water-contact WASH/behaviour; **complementary** to Wave BW deworming (**no** END Fund/STH/combination CE duplicate); **cross-links** water (**chlorination ≠ snail/WASH**) + skin-NTD + anaemia | **No** org ingest (do not duplicate DtW/Unlimit/Sightsavers; no END Fund); drafts CE null / not_for_ranking; `cause_schistosomiasis` future-only; no medical dosing |
| **Schisto morbidity / FGS / FSAC systems** | WHO (genital-manifestations ~56M FGS; Pocket Atlas; simultaneous-screening; fact sheet); GiveWell — dated schisto MDA **cite-only** (Wave ER) + FGS/FSAC systems **honest null**; IHME GBD | Maps **no live FGS/FSAC systems interventions** vs FGS clinical recognition, SRH–HIV–cervical integration, morbidity–WASH–snail systems; **complementary** to Wave ER (**no dual CE**; MDA/PC + snail/WASH stay ER); **cross-links** deworming + water (**chlorination ≠ snail/WASH**) + HIV/syphilis/cervical | **No** org ingest (Sightsavers deworming-only; no Merck/END Fund/FIG); drafts CE null / not_for_ranking; `cause_schisto_morbidity` future-only; no medical dosing / lesion how-to |
| **Lymphatic filariasis / onchocerciasis** | WHO (LF ~657M needing PC; MMDP; GPELF; oncho ~252.3M needing PC 2024; ≥80% coverage; NTD road map); GiveWell — dated LF + river-blindness MDA (**cite-only**; DCP2 $/DALY quarantined); IHME GBD | Maps **no live LF/oncho interventions** vs LF MDA, thin MMDP, oncho ivermectin MDA; **complementary** to Wave BW deworming (**no** END Fund/STH/combination CE duplicate); **cross-links** vision (**trachoma ≠ oncho**) + skin-NTD + schisto + Wave FZ MMDP systems | **No** org ingest (do not duplicate DtW/Unlimit/Sightsavers; no Carter Center/END Fund/Merck); drafts CE null / not_for_ranking; `cause_lf_onchocerciasis` future-only; no medical dosing |
| **LF MMDP / hydrocele / lymphedema systems** | WHO (MMDP ~40M manifestations; minimum package; 2019 surgical approaches; GPELF progress); GiveWell — dated LF MDA **cite-only** (Wave EV) + MMDP systems **honest null**; IHME GBD | Maps **no live MMDP systems interventions** vs hydrocele surgery access, lymphoedema care access, facility readiness / patient estimation; **complementary** to Wave EV (**no dual CE**; MDA/elimination stay EV); **cross-links** deworming + skin/leprosy/Buruli + trachoma (**TT ≠ hydrocele**) | **No** org ingest (Sightsavers deworming-only; no Carter Center/END Fund); drafts CE null / not_for_ranking; `cause_lf_mmdp` future-only; no medical dosing / surgical how-to |
| **LF MDA / transmission interruption programme systems** | WHO (GPELF MDA; fact sheet; progress 2024; monitoring manual 2025 TAS/EMS/IDA/PVS; GHO); GiveWell — dated LF MDA **cite-only** (Wave EV thin `int_lf_mda`) + LF MDA Top Charity / refreshed CEA **honest null**; IHME GBD | Maps **no live LF-MDA-systems interventions** vs campaign delivery & coverage, TAS/stop-MDA/surveillance, IDA/persistent-transmission remediation; **complementary** to Wave EV (**no dual CE**; thin `int_lf_mda` stays EV); **Wave FZ MMDP ≠ MDA**; **Wave GB oncho ≠ LF MDA**; **no dual CE** with deworming | **No** org ingest (Sightsavers deworming-only; no Carter Center/END Fund); drafts CE null / not_for_ranking; `cause_lf_mda` future-only; no medical dosing / IDA regimen how-to |
| **Nutrition / micronutrient fortification (expansion)** | GiveWell (Helen Keller VAS Top Charity; iron fortification; IFA / rice; Africa anemia RFI; MMS study); HLI (Taimaka / Fortify Health — **already live**) | Maps live VAS / wheat fortification / CMAM / EA IFA org vs salt iodization, maternal MMS, rice fortification, Africa iron RFI, school-age IFA | **No new** orgs (do not duplicate Helen Keller / Fortify Health / EA IFA / Taimaka); drafts CE null / not_for_ranking; no `cause_fortification` |
| **Anaemia / iron deficiency (LMIC multi-etiology)** | WHO (fact sheet Feb 2025; accelerating framework; 2025 estimates); GiveWell iron fortification/IFA/Africa RFI/podcast (**cite-only — nutrition owns CE**); IHME/GBD | Maps **no live anaemia-specific cause** vs etiology surveillance, malaria/helminth co-driver pathways, maternal anaemia pathway shape; **cross-links** nutrition (**no IFA/fortification/MMS/VAS duplicate**) + maternal + malaria (**no ITN/SMC**) + deworming (**no MDA**) + sickle | **No** org ingest; drafts CE null / not_for_ranking; `cause_anemia` future-only; no medical dosing |
| **Iodine deficiency / USI / goiter** | WHO (salt-iodization guideline; IDD assessment/monitoring guide; systematic review); GiveWell salt iodization (**cite-only — nutrition owns** manufacturer draft); IHME/GBD | Maps **no live iodine-specific cause** vs UIC/goiter surveillance, USI quality/coverage systems, residual severe-pocket supplementation shape; **cross-links** nutrition (**no VAS/IFA/MMS/iron/salt-iodization-draft duplicate**) + anaemia (**stay separate**) + hypertension (salt-CVD stays HTN) | **No** org ingest (do not duplicate IGN); drafts CE null / not_for_ranking; `cause_iodine_deficiency` future-only; no medical dosing |
| **Vitamin D deficiency / nutritional rickets** | WHO (2025 oils/fats vitamins A+D fortification guideline; 2019 nutritional rickets review — not a guideline; eLENA infants further-research / **404** at build); GiveWell — **no** dedicated VDD/rickets CEA / Top Charity (**honest null**; VAS cite-only A≠D — nutrition owns); IHME/GBD thin dedicated-row honesty | Maps **no live VDD/rickets interventions** vs 25(OH)D/rickets surveillance, oil/fat vitamin D fortification systems, infant/maternal supplementation shape (LMIC pediatric+maternal); **cross-links** nutrition (**no VAS/IFA/MMS/iron/iodization-draft duplicate**) + anaemia + iodine (**stay separate**) + maternal (**no EmONC**) + osteoporosis/falls (adult stays ED) | **No** org ingest; drafts CE null / not_for_ranking; `cause_vitamin_d_rickets` future-only; no medical dosing |
| **Immunization / vaccines (expansion)** | GiveWell (New Incentives Top Charity; vaccines strategy; IRD/Suvita; Mar 2026 outreach RFI; measles SIAs; HPV); **Gavi bibliography-only** | Maps live New Incentives / `int_cci` (+ related PATH malaria vaccine TA) vs IRD mCCT, SMS reminders, targeted outreach, measles SIAs, HPV drafts | **No new** orgs (do not duplicate New Incentives / PATH / MC; no IRD / Suvita / Gavi ingest); drafts CE null / not_for_ranking; controversies flagged |
| **Malaria (ITNs / SMC / seasonal expansion)** | GiveWell (AMF ITNs + Malaria Consortium SMC Top Charities — **already live**; PATH vaccine/PMC grants; IRS thin) | Maps live AMF / MC / thin vaccine TA vs PMC, IRS, and RTS,S/R21 bibliography-only | **No new** orgs (do not duplicate AMF / MC / PATH); drafts CE null / not_for_ranking; vaccines bibliography-only; no `cause_vector_control` |
| **Tuberculosis (TB)** | GiveWell (TB HCM / TPT–IPT; mass screen-and-treat ACF; CHAI/Spiro grants bibliography; **TB CEA cells bibliography-only**) | Maps **no live TB orgs/interventions** vs ACF + IPT/TPT drafts; disambiguates live `int_group_ipt` (mental health) | **No** TB org ingest; drafts CE null / not_for_ranking; `cause_tuberculosis` future-only; cells bibliography-only |
| **HIV / AIDS** | GiveWell (oral PrEP; VMMC; ART / treatment support — interim reports; 2025–26 aid-cut reassessment; **HIV CEA cells bibliography-only**) | Maps **no live HIV orgs/interventions** vs PrEP, VMMC, ART/treatment-support drafts; cells bibliography-only; sensitive-topic (no medical advice) | **No** HIV org ingest; drafts CE null / not_for_ranking; `cause_hiv` future-only; cells bibliography-only; do not duplicate immunization HPV |
| **Diarrhea / ORS / cholera** | GiveWell (ORS/zinc report; CHAI Bauchi / Clear Solutions / NI ORSZ; JHU CHoBI7; **ORS/zinc CEA cells bibliography-only**); WHO burden | Maps **no live ORS intervention** vs free ORS+zinc, mass/door-to-door, SMC layering, immunization co-delivery, thin OCV, CHoBI7/PICHA7; **cross-links** live water chlorination + `org_new_incentives_ors` (no duplicates) | **No new** orgs (do not duplicate NI-ORS / EA water; no CHAI/Clear Solutions/JHU ingest); drafts CE null / not_for_ranking; `cause_diarrhea` future-only; cells bibliography-only |
| **Childhood pneumonia / ARI** | GiveWell (iCCM interim; R4D amox-DT grants + lookback; new-areas oxygen/pulse-ox; **iCCM + R4D CEA cells bibliography-only**); WHO / IHME LRI burden | Maps **no live pneumonia treatment interventions** vs pulse oximetry, medical oxygen access, community case management of pneumonia, pediatric amoxicillin-DT access; **cross-links** immunization PCV/Hib (`int_cci`) — no vaccine CE duplicate; HAP stays air-quality; diarrhea/ORS separate | **No new** orgs (no R4D/IRC/PATH oxygen-arm; do not duplicate NI); drafts CE null / not_for_ranking; `cause_pneumonia` future-only; cells bibliography-only |
| **Neonatal sepsis / SBI care systems** | GiveWell — **no** dedicated PSBI/neonatal-sepsis treatment CEA (**honest null**); CHX cord care **cite-only** (preliminary cells quarantine); WHO SBI 2024 + PSBI referral-not-feasible | Maps **no live neonatal-sepsis interventions** vs PSBI outpatient systems, facility SBI care access, CHX cord care; **complementary** to maternal (**no EmONC CE duplicate**) + pneumonia (**no childhood amox/iCCM/oxygen CE duplicate**); **cross-links** meningitis + syphilis | **No** org ingest; drafts CE null / not_for_ranking; `cause_neonatal_sepsis` future-only; no medical dosing |
| **Postpartum sepsis / maternal infection IPC systems** | GiveWell — **no** dedicated postpartum-sepsis / maternal-sepsis CEA (**honest null** beyond facility MNH infection-prevention component cites — maternal owns); WHO peripartum infections 2015 + Statement on Maternal Sepsis + APT-Sepsis Nov 2025 | Maps **no live postpartum-sepsis interventions** vs facility maternity IPC, early-recognition/response (FAST-M shape), infection referral/care-access; **complementary** to maternal (**no EmONC CE duplicate**) + PPH + neonatal sepsis + syphilis | **No** org ingest; drafts CE null / not_for_ranking; `cause_postpartum_sepsis` future-only; no medical dosing |
| **Preterm birth / ACS care systems** | GiveWell — **no** dedicated ACS / preterm-birth CEA / Top Charity (**honest null** beyond facility MNH component cites); WHO ACS 2022 + preterm fact sheet | Maps **no live ACS interventions** vs ACS access / preterm referral / facility readiness; **cross-links** maternal (**no EmONC/ACS/KMC duplicate**) + neonatal sepsis + Wave FL stillbirth + PPH + preeclampsia + obstructed labor | **No** org ingest; drafts CE null / not_for_ranking; `cause_preterm_birth` future-only; no medical dosing |
| **Stillbirth / perinatal mortality prevention systems** | GiveWell — **no** dedicated stillbirth / MPDSR CEA (**honest null**); facility/community/PLA stillbirth outcomes **maternal-owned** cite-only; WHO MPDSR / ENAP / ICD-PM / Labour Care Guide | Maps **no live stillbirth interventions** vs surveillance/response, intrapartum prevention systems, antepartum risk/ANC systems; **complementary** to maternal (**no EmONC/package CE duplicate**) + PPH + PE + neonatal sepsis + fistula + OL + syphilis | **No** org ingest; drafts CE null / not_for_ranking; `cause_stillbirth` future-only; no medical dosing |
| **Pain / palliative care** | **HLI** (Pain Exploration 3; 2020/2023 pain reports; 2025 Giving Season — Pallium in progress); **GiveWell bibliography-only/N/A** | Maps **no live pain orgs/interventions** vs palliative opioid-access systems, thin MSK PT, hypothetical psychotherapy-for-pain; HLI Pallium BOTECs bibliography-only; cross-link MH `int_mh_palliative_care_access` | **No** pain org ingest; drafts CE null / not_for_ranking; `cause_pain_palliative` future-only; BOTECs bibliography-only; **no medical advice**; do not duplicate MH palliative stub |
| **Hypertension / cardiovascular** | GiveWell (dietary salt modification Jul 2025; community salt substitution; nutrition strategy CVD H2; PH-regulation sodium vs lead); WHO HEARTS/burden bibliography | Maps **no live hypertension interventions** vs dietary salt modification, potassium salt-substitute scale-up, community substitution, thin antihypertensive/HEARTS access, sodium policy; **cross-links** live Pure Earth (lead) + air-quality HAP CVD burden (no duplicates); GiveWell dietary-salt/community-salt CEA cells + Pure Earth/lead vs hypertension-meds cells **bibliography-only** | **No new** orgs (do not duplicate Pure Earth; no RTSL/WASH ingest); drafts CE null / not_for_ranking; `cause_hypertension` future-only; cells bibliography-only |
| **Diabetes / metabolic NCD** | WHO (fact sheet; Compact; HEARTS-D; interventions brief); IHME/Lancet GBD diabetes; GiveWell context only (nutrition H2 SSB; NCD Best Buys PDF — **no** deep diabetes CEA) | Maps **no live diabetes interventions** vs T2 prevention, metformin/insulin LMIC access, foot care, retinopathy screening, thin SSB/diet advocacy; **cross-links** hypertension (no salt-sub duplicate) + air-quality HAP→CVD (stay air-quality) + vision (cataract/trachoma separate); WHO Best Buys / GBD figures **bibliography-only** | **No new** orgs; drafts CE null / not_for_ranking; `cause_diabetes` future-only; cells bibliography-only; ADR 0007 Proposed (no mid-age NCD↔under-5 mix) |
| **Glaucoma / diabetic retinopathy** | WHO (blindness/vision fact sheet; glaucoma ~7.7M / DR ~3.9M; World report on vision / IPEC; diabetes brief D2); GiveWell — **no** dedicated glaucoma/DR CEA (**honest null**; cataract/SAFE cite-only — vision owns); IHME/VLEG/GBD | Maps **no live glaucoma/DR interventions** vs glaucoma case-finding + treatment access, DR sight-threatening treatment access, thin IPEC systems (LMIC beyond trachoma/cataract); **cross-links** vision (**no SAFE/cataract duplicate**) + diabetes (**glycemic CE + screening stub stay diabetes**) | **No** org ingest; drafts CE null / not_for_ranking; `cause_glaucoma_retinopathy` future-only; WHO 411B bibliography-only; no medical dosing/laser protocols |
| **Hepatitis B / C** | WHO (HepB/HepC/blood-safety fact sheets; Global hepatitis report 2026); GiveWell (NI pentavalent + indirect HepB BD — **vaccine CE cross-link only**; **no** dedicated Hep CEA); **Gavi bibliography-only** | Maps **no live hepatitis interventions** vs HepB birth-dose coverage gap, testing & treatment access (HCV DAAs bibliography), blood/injection safety; **cross-links** immunization `int_cci` (no duplicate vaccine CE) + HIV co-infection notes only | **No** org ingest (no Gavi/CHAI/Unitaid); drafts CE null / not_for_ranking; `cause_hepatitis` future-only; no medical advice |
| **Cirrhosis / chronic liver disease** | WHO (HepB/HepC — cirrhosis/HCC pathway; Global hepatitis report 2026; alcohol liver-disease co-driver; **no** dedicated cirrhosis fact sheet); GiveWell — **no** dedicated cirrhosis/CLD CEA / Top Charity (**honest thin-evidence**); IHME/GBD 2021 | Maps **no live cirrhosis interventions** vs CLD care access, viral hepatitis sequelae linkage, alcohol co-driver themes (LMIC); **cross-links** hepatitis (**no HepB-BD/DAA duplicate**) + alcohol-tobacco (**no SAFER/RESET duplicate**) + immunization | **No** org ingest; drafts CE null / not_for_ranking; `cause_cirrhosis` future-only; no medical protocols |
| **Pandemic / biosecurity preparedness** | Coefficient Biosecurity & Pandemic Preparedness; Founders Pledge biosecurity / GCBR / GCR Fund; GWWC Risks & Resilience; 80k framing | Maps **no live biosecurity orgs/interventions** vs pathogen-agnostic PPE policy, early detection capacity, Far-UVC/GUV themes, governance/norms, fund vehicles; **cross-link** GCR thin biosecurity stub | **No** biosecurity org ingest; drafts CE null / not_for_ranking; `cause_pandemic_preparedness` future-only; **info-hazard** high-level only (no dual-use); do not duplicate GCR stub |
| **Road safety / traffic injury** | GiveWell (Zusha! standout — discontinued; incubation; 2017 blog; 2009 DCP speed/speed-bumps pointer; 2019 AIP Helmets for Kids — not selected; **Zusha! CEA cells bibliography-only**); WHO fact sheet + Global status 2023; IHME GBD | Maps **no live road-safety interventions** vs speed enforcement, speed bumps, motorcycle/child helmets, drink-drive enforcement, thin trauma/post-crash care, Zusha!-class speak-up stickers; **cross-links** maternal (no obstetric trauma duplicate) + lead + air (stay separate) | **No new** orgs (no gui2de/Zusha!/AIP); drafts CE null / not_for_ranking; `cause_road_safety` future-only; cells bibliography-only |
| **Drowning / child water safety** | WHO (fact sheet; Guideline day-care + swim skills strong recommendations; practical guidance); IHME GBD Results; GiveWell — **no** dedicated drowning CEA | Maps **no live drowning interventions** vs daycare/creche supervision, basic swim/water-safety skills, barriers (wells/doorways/playpens/fencing); **cross-links** road-safety trauma + safe-water/WASH diarrhoea (stay separate); WHO investment-case cost-saving **bibliography-only** | **No new** orgs (no CIPRB/SwimSafe/Bloomberg drowning); drafts CE null / not_for_ranking; `cause_drowning` future-only; no invented CE |
| **Snakebite envenoming** | WHO (fact sheet; 2019 strategy; antivenoms); GiveWell (Dec 2022 open-thread — 2017 below-bar unpublished; **bibliography-only**); IHME Nature Comm 2022 | Maps **no live snakebite interventions** vs antivenom access, community first-response (no clinical how-to), thin health-systems case management; **cross-links** skin-NTD + deworming/other-NTD (snakebite ≠ MDA/PC ≠ skin-NTD) | **No** org ingest (no Wellcome/MSF/GSI; do not expand Sightsavers); drafts CE null / not_for_ranking; `cause_snakebite` future-only; no medical advice |
| **Postpartum hemorrhage (PPH) care systems; obstetric fistula** | GiveWell (fistula surgery Dec 2021 — **below funding bar**; BOTE bibliography-only); WHO (facts-in-pictures; guiding principles) | Maps **no live fistula interventions** vs surgical repair access + prevention via timely C-section / obstructed-labor care; **cross-links** maternal (thin `int_mn_fistula_repair`; **no EmONC CE duplicate**) | **No** org ingest (no Fistula Foundation/Hamlin/EngenderHealth); drafts CE null / not_for_ranking; `cause_fistula` future-only; no medical advice |
| **Sickle cell disease** | WHO (fact sheet; childhood guideline; AFRO strategy/PEN-Plus); GiveWell — **no** dedicated SCD CEA / Top Charity (**honest thin-evidence**); IHME GBD 2021 | Maps **no live SCD interventions** vs newborn screening, penicillin prophylaxis, hydroxyurea access, transfusion/malaria co-management (high level); **cross-links** malaria (no ITN/SMC/PMC CE duplicate) + maternal + immunization (PCV/Hib) | **No** org ingest; drafts CE null / not_for_ranking; `cause_sickle_cell` future-only; no medical advice |
| **Noma / severe oral-facial gangrene & oral health** | WHO (fact sheet; Dec 2023 NTD listing; oral-health co-mention); GiveWell — **no** dedicated noma CEA / Top Charity (**honest thin-evidence**); IHME/GBD noma not computed | Maps **no live noma interventions** vs early detection/acute care, nutrition co-factors, reconstructive surgery access (LMIC); **cross-links** nutrition (no VAS/CMAM CE duplicate) + skin-NTD (platform only) + maternal/fistula (no EmONC duplicate) | **No** org ingest; drafts CE null / not_for_ranking; `cause_noma` future-only; WHO 1998 burden bibliography-only; no medical advice |
| **Leprosy (Hansen’s disease)** | WHO (fact sheet ~200k new cases/year; Global Leprosy Strategy 2021–2030; free MDT; contact screening); GiveWell — **no** dedicated leprosy CEA (**honest null**); IHME GBD bibliography | Maps **no live leprosy interventions** vs ACD/contact screening, MDT access & continuity, disability prevention / stigma–rehab; **complementary** to Wave CS skin-NTD (**no** scabies/yaws MDA or thin `int_skin_ntd_leprosy_*` duplicate); **cross-links** noma + schisto + LF/oncho + deworming | **No** org ingest (no ILEP/Lepra/Leprosy Mission; Sightsavers deworming-only); drafts CE null / not_for_ranking; `cause_leprosy` future-only; no medical dosing |
| **Human African trypanosomiasis (HAT / sleeping sickness)** | WHO (HAT fact sheet; GHO; EOT verification; Chagas disambiguation); GiveWell — **no** dedicated HAT CEA (**honest null**); IHME GBD bibliography | Maps **no live HAT interventions** vs screening & treatment access, tsetse vector-control systems, elimination/surveillance; **Wave FC owns Chagas** (*T. cruzi* ≠ *T. brucei*); **complementary** to Wave FA VL (**sandfly ≠ tsetse**); **cross-links** LF/oncho + schisto + skin-NTD + leprosy + deworming | **No** org ingest (no DNDi/MSF/FIND; Sightsavers deworming-only); drafts CE null / not_for_ranking; `cause_hat` future-only; no medical dosing |
| **Chagas disease (American trypanosomiasis)** | WHO (fact sheet ~8M infected; >10k deaths/yr; vector/congenital/blood screening; NTD road map); GiveWell — **no** dedicated Chagas CEA (**honest null**); IHME GBD bibliography | Maps **no live Chagas interventions** vs vector-control systems, screening & treatment access, congenital/blood–organ screening; **complementary** to Wave FA VL (**Chagas ≠ VL**) + LF/schisto/skin-NTD/leprosy/deworming; **cross-links** RHD/IHD (cardiomyopathy ≠ RHD ≠ IHD) | **No** org ingest (no DNDi/MSF/Mundo Sano; Sightsavers deworming-only); drafts CE null / not_for_ranking; `cause_chagas` future-only; no medical dosing |
| **Buruli ulcer (*Mycobacterium ulcerans*)** | WHO (fact sheet ≥33 countries; early detection + antibiotics; GHO; skin-NTD framework); GiveWell — **no** dedicated Buruli CEA (**honest null**); IHME GBD bibliography | Maps **no live Buruli interventions** vs case-finding, treatment-access & lab confirmation, disability / wound–lymphoedema / rehab; **complementary** to Wave CS skin-NTD (**no** scabies/yaws MDA or thin `int_skin_ntd_other_buruli_cl_mycetoma` duplicate); **cross-links** leprosy + noma + LF/oncho + VL + deworming | **No** org ingest (no ALM/Anesvad/FIND; Sightsavers deworming-only); drafts CE null / not_for_ranking; `cause_buruli_ulcer` future-only; no medical dosing |
| **Yaws (*T. pallidum* subsp. *pertenue*)** | WHO (fact sheet ~15 endemic countries; Morges TCT + surveillance; eradication criteria; skin-NTD framework); GiveWell — **no** dedicated yaws CEA (**honest null**); IHME GBD bibliography | Maps **no live yaws interventions** vs case-finding, MDA/TCT access & coverage, post-MDA surveillance; **complementary** to Wave CS skin-NTD (**keep** thin `int_skin_ntd_yaws_azithromycin_morges`; **no** dual CE); **cross-links** Buruli + CL + leprosy + vision/trachoma + deworming; mycetoma thin CS only | **No** org ingest (no EMS/yaws NGOs; Sightsavers deworming-only); drafts CE null / not_for_ranking; `cause_yaws` future-only; no medical dosing |
| **Scabies (*Sarcoptes scabiei*)** | WHO (fact sheet ≥200M; MDA ≥10%; UHC targets; crusted/outbreak; skin-NTD framework); GiveWell — Sep 2021 MDA **cite-only** (CEA cells Wave CS; below-bar) + systems **honest null**; IHME GBD bibliography | Maps **no live scabies systems interventions** vs MDA-access/delivery, case-management/household access, crusted-outbreak systems; **complementary** to Wave CS skin-NTD (**keep** thin `int_skin_ntd_scabies_ivermectin_mda`; **no** dual CE); **cross-links** yaws + Buruli + CL + leprosy + mycetoma + deworming | **No** org ingest (no WSEP; Sightsavers deworming-only); drafts CE null / not_for_ranking; `cause_scabies` future-only; no medical dosing |
—. **Acute poisoning / toxic exposures** — No live poisoning interventions. GiveWell CPSP cite-only + honest null acute unintentional CEA; WHO poison centres / pesticides / HAP kerosene-ingestion; LEEP stays lead. Cross-link snakebite (no dual CE) + burns (ingestion ≠ flame) + road-safety. Info-hazard high-level only. No medical dosing.
| **Acute poisoning / toxic exposures** | WHO (poison centres; pesticides; household pesticides; HAP kerosene-ingestion); GiveWell — CPSP **cite-only** + **honest null** acute unintentional CEA; LEEP stays lead; IHME GBD bibliography | Maps **no live poisoning interventions** vs HHP regulation systems, paraffin ingestion prevention, household safe-storage, poison-centre capacity; **cross-links** lead (LEEP) + snakebite (**no dual CE**) + burns (ingestion ≠ flame) + road-safety | **No** org ingest; drafts CE null / not_for_ranking; `cause_poisoning` future-only; info-hazard high-level only; no medical dosing |
| **Oral health beyond noma (caries / periodontal / fluoride)** | WHO (oral-health fact sheet ~3.7B; untreated permanent caries most common GBD 2021; >1B severe periodontal; Global status report + strategy/GOHAP 2023–2030); GiveWell — **no** dedicated oral-health / fluoride / caries CEA / Top Charity (**honest thin-evidence**); IHME/Lancet GBD 2021 oral conditions | Maps **no live oral-health interventions** vs caries prevention/care access, periodontal care + tobacco co-factor systems, PHC/UHC oral-health integration (LMIC); fluoride water/salt/toothpaste **bibliography-only (no dosing)**; **complementary** to Wave DS noma (**no noma draft duplicate**); **cross-links** nutrition (iodization ≠ fluoridation) + water (chlorination ≠ fluoridation) + alcohol-tobacco (no MPOWER duplicate) + diabetes (no metabolic duplicate) | **No** org ingest; drafts CE null / not_for_ranking; `cause_oral_health` future-only; no medical/fluoride dosing |
| **COPD exacerbation / chronic respiratory care pathway** | WHO (COPD fact sheet — flare-ups/oxygen/rehab; rehab Module 4); GiveWell — **no** dedicated COPD-exacerbation / pulmonary-rehab / LTOT CEA / Top Charity (**honest thin-evidence**); IHME/GBD 2021 | Maps **no live pathway interventions** vs LMIC exacerbation care systems, pulmonary rehab access, chronic/long-term oxygen (adult CRD); **complementary** to Wave DX (**no inhaler/PEN duplicate**); **cross-links** pneumonia (**no childhood oxygen**) + air-quality (**no HAP CE**) + alcohol-tobacco (**no MPOWER**) | **No** org ingest; drafts CE null / not_for_ranking; `cause_copd_exacerbation` future-only; no medical dosing |
| **Asthma / COPD / CRD** | WHO (asthma + COPD fact sheets; CRD topic; PEN); GiveWell — **no** dedicated asthma/COPD / inhaler CEA / Top Charity (**honest thin-evidence**); IHME/GBD 2021 | Maps **no live CRD interventions** vs inhaler access, PEN primary-care CRD, prevention/exposure themes (HAP + tobacco **cross-link only**); **cross-links** air-quality (**no HAP CE duplicate**) + alcohol-tobacco (**no MPOWER duplicate**) + pneumonia (**no amox-DT duplicate**) | **No** org ingest; drafts CE null / not_for_ranking; `cause_asthma_copd` future-only; no medical dosing |
| **Epilepsy / seizure disorders** | WHO (fact sheet; IGAP 2022–2031; mhGAP-IG epilepsy module; technical brief); GiveWell — **no** dedicated epilepsy / phenobarbital CEA / Top Charity (**honest thin-evidence**); IHME/Lancet Public Health GBD 2021 | Maps **no live epilepsy interventions** vs ASM/phenobarbital access, mhGAP primary-care integration, thin stigma/care-seeking (LMIC treatment gap); **cross-links** mental-health (**no IPT duplicate**) + pain/palliative (**no morphine draft duplicate**) | **No** org ingest; drafts CE null / not_for_ranking; `cause_epilepsy` future-only; no medical advice / ASM dosing |
| **Meningitis / meningococcal disease** | WHO (fact sheet; Defeating Meningitis by 2030; AFRO belt; MenAfriVac/Men5CV shape); GiveWell Meningitis A (2016) — **RFMF-stop / incomplete investigation** (**honest thin-evidence**; no completed CEA/Top Charity); IHME/GBD 2023 | Maps **no live meningitis interventions** vs belt epidemic surveillance & outbreak response, diagnosis/treatment care access, post-meningitis sequelae support (LMIC); **cross-links** immunization (PCV/Hib/MenA/Men5CV — no vaccine CE duplicate) + hearing-loss (sequelae notes only) | **No** org ingest; drafts CE null / not_for_ranking; `cause_meningitis` future-only; GW RFMF-stop bibliography-only; no medical advice |
| **MenA / meningococcal conjugate vaccine systems** | WHO (fact sheet; Jan 2024 MMCV belt position paper; Defeating Meningitis); GiveWell — dedicated MenA Top Charity / completed CEA **honest null** (Jan 2016 RFMF-stop cite-only); IHME/GBD; Gavi meningococcal bibliography (Wave BZ owns Gavi) | Maps **no live MenA systems interventions** vs MenAfriVac/MenA mass-campaign, Men5CV/MMCV introduction, MenA/Men5CV routine–catch-up systems; **complementary** to Wave DU meningitis (belt/care/sequelae stay meningitis; **no dual CE**) + Wave BZ immunization (**no dual routine-EPI CE**); **Hib ≠ MenA**; **PCV ≠ MenA** | **No** org ingest; drafts CE null / not_for_ranking; `cause_meningococcal` future-only; no medical dosing |
| **Malaria SMC / seasonal chemoprevention systems** | WHO (fact sheet; guidelines; SMC field guide 2nd ed.; WMR 2024); GiveWell — SMC Top Charity **cite by reference only** (live `int_smc`); IHME/GBD | Maps **SMC systems deepen** vs live malaria Top Charity CE: campaign delivery & coverage, geographic expansion & seasonal targeting, related chemoprevention (IPTp + IPTsc/PDMC adjacency); **complementary** to live `cause_malaria` (**no dual CE**; Wave BY PMC/IRS stay malaria); pneumonia/maternal adjacency | **No** org ingest; drafts CE null / not_for_ranking; `cause_malaria_smc` future-only; no medical dosing |
| **IPTp / malaria in pregnancy systems** | WHO (Guidelines for malaria; Jun 2022 chemoprevention; Jan 2024 c-IPTp; WMR/GHO IPTp3); GiveWell — IPTp Top Charity **honest null** (preliminary CEA quarantine); IHME/GBD | Maps **no live IPTp interventions** vs IPTp-SP ANC delivery/coverage, community c-IPTp, MiP/ANC integration; **complementary** to live malaria (**no dual ITN/SMC CE**) + Wave HT childhood SMC (**SMC ≠ IPTp**) + Wave CB maternal (**no dual EmONC CE**) | **No** org ingest; drafts CE null / not_for_ranking; `cause_malaria_iptp` future-only; no medical dosing |
| **Malaria IRS / indoor residual spray systems** | WHO (fact sheet ITNs+IRS; guidelines; IRS operational manual Feb 2024; IRM; WMR); GiveWell — AMF/ITN **cite by reference only** (IRS Top Charity honest null); IHME/GBD | Maps **IRS systems deepen** vs live malaria ITN CE: campaign delivery & coverage, IRM, ITN↔IRS prioritization; **complementary** to live malaria (**no dual CE**; Wave BY thin IRS stay malaria) + HT SMC ≠ IRS + HV IPTp ≠ IRS | **No** org ingest; drafts CE null / not_for_ranking; `cause_malaria_irs` future-only; no pesticide how-to |
| **PMC / perennial malaria chemoprevention systems** | WHO (Guidelines for malaria; Jun 2022 chemoprevention — IPTi→PMC; fact sheet; WMR); GiveWell — PMC Top Charity **honest null** (PATH DRC pilot grant CEA quarantine); IHME/GBD | Maps **no live PMC-systems interventions** vs EPI-platform delivery/coverage, geographic/age-group expansion, programme integration/scale-up M&E; **complementary** to live malaria (**no dual ITN/SMC CE**; Wave BY thin `int_malaria_pmc` stay malaria) + Wave HT SMC (**SMC ≠ PMC**) + Wave HV IPTp (**IPTp ≠ PMC**) + Wave IA IRS (**IRS ≠ PMC**) | **No** org ingest; drafts CE null / not_for_ranking; `cause_malaria_pmc` future-only; no medical dosing |
| **IPTi / intermittent preventive treatment in infants systems** | WHO (Guidelines for malaria; Jun 2022 chemoprevention — IPTi→PMC; fact sheet; WMR); GiveWell — IPTi Top Charity **honest null** (interim preliminary CEA quarantine); IHME/GBD | Maps **no live IPTi-systems interventions** vs EPI-contact delivery, coverage/supervision, surveillance–targeting; **complementary** to live malaria (**no dual ITN/SMC CE**) + Wave IB PMC (sibling; **no dual CE**) + Wave HT SMC (**SMC ≠ IPTi**) + Wave HV IPTp (**IPTp ≠ IPTi**) + Wave IN CM (**CM ≠ prevention**) | **No** org ingest; drafts CE null / not_for_ranking; `cause_malaria_ipti` future-only; no medical dosing |
| **Malaria MDA / mass screening-and-treatment programme systems** | WHO (fact sheet; guidelines MDA family; elimination recommendations; role-of-MDA/MSAT note; WMR); GiveWell — AMF/ITN + MC/SMC **cite by reference only** (MDA Top Charity / dedicated CEA **honest null**); IHME/GBD | Maps **no live MDA-systems interventions** vs elimination-setting MDA campaigns, outbreak/reactive MDA, MSAT/screening-linked programmes; **complementary** to live malaria (**no dual ITN/SMC CE**) + Wave HT SMC (**SMC ≠ MDA**) + Wave HV IPTp (**IPTp ≠ MDA**) + Wave IB PMC (**PMC ≠ MDA**) + Wave IR IPTi (**IPTi ≠ MDA**) + Wave IN CM (**CM ≠ MDA**) | **No** org ingest; drafts CE null / not_for_ranking; `cause_malaria_mda` future-only; no medical dosing |
| **Malaria IPTsc / school-age chemoprevention systems** | WHO (fact sheet; guidelines IPTsc family; Jun 2022; preventive-chemotherapies; WMR); GiveWell — AMF/ITN + MC/SMC **cite by reference only** (IPTsc Top Charity / dedicated CEA **honest null**); IHME/GBD | Maps **no live IPTsc-systems interventions** vs school-platform delivery, coverage/equity/alternative channels, surveillance-targeting / under-5 complementarity; **complementary** to live malaria (**no dual ITN/SMC CE**) + Wave HT SMC (**SMC ≠ IPTsc**) + Wave HV IPTp (**IPTp ≠ IPTsc**) + Wave IB PMC (**PMC ≠ IPTsc**) + Wave IR IPTi (**IPTi ≠ IPTsc**) + Wave IU MDA (**MDA ≠ IPTsc**) + Wave IN CM (**CM ≠ prevention**) | **No** org ingest; drafts CE null / not_for_ranking; `cause_malaria_iptsc` future-only; no medical dosing |
| **Malaria RACD / reactive case detection systems** | WHO (fact sheet; guidelines; elimination RACDT/RDA; WMR); GiveWell — AMF/ITN + MC/SMC **cite by reference only** (RACD Top Charity / dedicated CEA **honest null**); IHME/GBD | Maps **no live RACD-systems interventions** vs RACDT, reactive surveillance/case investigation, RDA (≠ mass MDA); **complementary** to live malaria (**no dual ITN/SMC CE**) + Wave IU MDA (**mass ≠ reactive**) + Wave IN CM (**care ≠ reactive detection**) | **No** org ingest; drafts CE null / not_for_ranking; `cause_malaria_racd` future-only; no medical dosing |
| **Japanese encephalitis / arboviral encephalitis vaccine systems** | WHO (fact sheet; IVB; 2015 position paper); GiveWell — JE CEA **honest null**; Gavi JE portfolio bibliography (Wave BZ owns Gavi) | Maps **no live JE interventions** vs vaccine introduction, catch-up campaigns, AEFI surveillance systems; **complementary** to Wave BZ immunization (**no dual routine-EPI CE**); **cross-links** meningitis (≠ bacterial) + pandemic; cross-link dengue/YF sibling packs | **No** org ingest (no Gavi/PATH/Chengdu; NI immunization-only); drafts CE null / not_for_ranking; `cause_japanese_encephalitis` future-only; no medical dosing |
| **Measles SIAs / outbreak response systems** | WHO (fact sheet; MRSF; SIA field guide; GMRLN; 2024/2025 burden news); GiveWell — measles-SIA Top Charity **honest null** (SIA intervention report cross-link/quarantine); IHME/GBD; Gavi measles/MR portfolio bibliography (Wave BZ owns Gavi) | Maps **no live measles systems interventions** vs preventive SIA campaigns, outbreak response immunization, surveillance/lab-access systems; **complementary** to Wave BZ immunization (**no dual routine-EPI CE**; thin measles-SIA draft stays immunization); **cross-links** meningitis (≠ bacterial) + pandemic + YF/cholera sibling campaigns | **No** org ingest (no Gavi/UNICEF/M&RP; NI immunization-only); drafts CE null / not_for_ranking; `cause_measles` future-only; no medical dosing |
| **Rubella / CRS systems** | WHO (fact sheet; position paper; Sep 2024 SAGE; CRS surveillance standards; MRSF/GMRLN); GiveWell — rubella/CRS Top Charity/CEA **honest null**; IHME/GBD; Gavi measles/MR portfolio bibliography (Wave BZ owns Gavi) | Maps **no live rubella/CRS systems interventions** vs RCV introduction, CRS surveillance programme-access, lab/case-based surveillance; **complementary** to Wave BZ immunization (**no dual routine-EPI CE**) + Wave GY measles (**≠ measles SIAs**); **cross-links** chik/Zika (CRS ≠ CZS) + maternal (programme only) | **No** org ingest; drafts CE null / not_for_ranking; `cause_rubella` future-only; no medical dosing / pregnancy clinical how-to |
| **Polio / nOPV / cVDPV systems** | WHO (fact sheet; strategy 2022–2026; nOPV2 PQ news; transition); GiveWell — polio Top Charity / CEA **honest null** (2016 vaccines blog incomplete-CEA cross-link/quarantine); IHME/GBD; Gavi IPV + GPEI strategy/GPLN bibliography (Wave BZ owns Gavi) | Maps **no live polio systems interventions** vs nOPV2 outbreak-response, endemic WPV campaigns, AFP/ES + GPLN lab-access systems; **complementary** to Wave BZ immunization (**no dual routine-EPI CE**; IPV-in-RI / NI OPV-IPV stay immunization); **cross-links** measles (sibling SIA ≠ polio) + meningitis (≠ bacterial) + pandemic/GCR PHEIC + YF/cholera sibling campaigns | **No** org ingest (no Gavi/UNICEF/Rotary/GPEI; NI immunization-only); drafts CE null / not_for_ranking; `cause_polio` future-only; no medical dosing |
| **Rotavirus vaccine (RVV) systems** | WHO (fact sheet; IVB; July 2021 position paper); GiveWell — dedicated RVV CEA / Top Charity **honest null** (NI rotavirus indirect cells stay Wave BZ); IHME/GBD; Gavi rotavirus portfolio bibliography (Wave BZ owns Gavi) | Maps **no live RVV systems interventions** vs introduction, catch-up, cold-chain & surveillance systems; **complementary** to Wave CG diarrhea (**ORS/zinc ≠ RVV**) + Wave BZ immunization (**no dual routine-EPI CE**); **cross-links** cholera/typhoid enteric siblings + water WASH | **No** org ingest (no Gavi/UNICEF/PATH/manufacturers; NI immunization-only); drafts CE null / not_for_ranking; `cause_rotavirus` future-only; no medical dosing / clinical rehydration how-to |
| **PCV / pneumococcal conjugate vaccine systems** | WHO (Sep 2025/2019 position paper; IVB; standardization); GiveWell — dedicated PCV Top Charity / CEA **honest null**; IHME/GBD; Gavi pneumococcal bibliography (Wave BZ owns Gavi) | Maps **no live PCV systems interventions** vs PCV introduction, catch-up/coverage-recovery, pneumonia–meningitis programme systems; **complementary** to Wave BZ immunization (**no dual routine-EPI CE**; PCV CE stays immunization); **PCV ≠ care** (pneumonia case management stays Wave DB); **Hib ≠ PCV**; meningitis MenA ≠ PCV; sibling SIAs ≠ PCV intro | **No** org ingest (no Gavi/PATH/manufacturers; NI immunization-only); drafts CE null / not_for_ranking; `cause_pcv` future-only; no medical dosing |
| **HPV vaccine introduction / catch-up / vaccination-pillar systems** | WHO (Dec 2022 position; IVB; product-choice; elimination 90% vaccination pillar); GiveWell — **no** HPV Top Charity; Oct 2020 vaccine CEA stays immunization; delivery-systems CEA **honest null**; IHME/GBD; Gavi HPV bibliography (Wave BZ owns Gavi) | Maps **no live HPV systems interventions** vs HPV introduction, MAC catch-up/coverage-recovery, elimination vaccination-pillar systems; **complementary** to Wave BZ immunization (**no dual CE**; thin `int_immunization_hpv` stays immunization); **HPV vaccine ≠ screening CE** (Wave CX owns VIA/DNA/treatment); rubella ≠ HPV; childhood cancer ≠ cervical HPV programme | **No** org ingest (no Gavi/PATH/CHAI/Jhpiego; NI immunization-only); drafts CE null / not_for_ranking; `cause_hpv` future-only; no medical dosing |
| **Varicella (chickenpox) / VZV vaccine introduction & catch-up systems** | WHO (Nov 2025 position; June 2014 historical; IVB; VPD surveillance); GiveWell — varicella Top Charity/CEA **honest null**; IHME/GBD; Gavi portfolio — varicella **not listed** (Wave BZ owns Gavi) | Maps **no live varicella systems interventions** vs introduction/routine, catch-up/SIA-like, surveillance–AEFI systems; **complementary** to Wave BZ immunization (**no dual EPI CE**); **measles ≠ varicella**; **rubella/CRS ≠ varicella**; MMRV bibliography only; zoster ≠ childhood varicella | **No** org ingest; drafts CE null / not_for_ranking; `cause_varicella` future-only; no medical dosing |
| **Hepatitis A (HAV) vaccine introduction / catch-up / outbreak systems** | WHO (Oct 2022 position; fact sheet; outbreak toolbox; VPD HepA); GiveWell — HepA Top Charity/CEA **honest null**; IHME/GBD; Gavi portfolio — HepA **not listed** (VIS 2018 deprioritised; Wave BZ owns Gavi) | Maps **no live HepA systems interventions** vs introduction/routine, catch-up/outbreak, foodborne/sanitation-adjacent systems; **complementary** to Wave BZ immunization (**no dual EPI CE**); **HepB ≠ HepA**; **HepC ≠ HepA**; WASH CE stays water; ORS ≠ HepA vaccine | **No** org ingest; drafts CE null / not_for_ranking; `cause_hepatitis_a` future-only; no medical dosing |
| **Seasonal influenza vaccine / programme systems** | WHO (May 2022 SAGE position; Global Influenza Strategy 2019–2030; toolkit; GISRS); GiveWell — seasonal influenza Top Charity/CEA **honest null**; IHME/GBD; Gavi portfolio — seasonal flu **not** current listed window (Wave BZ owns Gavi) | Maps **no live seasonal-flu systems interventions** vs risk-group routine, campaign/delivery, surveillance–vaccine-match systems; **complementary** to Wave BZ immunization (**no dual EPI CE**); **seasonal ≠ pandemic**; **pneumonia care ≠ flu vaccine** | **No** org ingest; drafts CE null / not_for_ranking; `cause_influenza` future-only; no medical dosing; no dual-use |
| **Hepatitis E vaccine / outbreak-response programme systems** | WHO/SAGE (May 2015 position; March 2024 SAGE FCV WCBA; fact sheet; outbreak toolbox; 2014 waterborne); GiveWell — HepE Top Charity/CEA **honest null**; IHME/GBD; Gavi VIS 2024 HepE stockpile bibliography (Wave BZ owns Gavi) | Maps **no live HepE systems interventions** vs outbreak-campaign, pregnancy/WCBA targeting, WASH-adjacent surveillance systems; **complementary** to Wave BZ immunization (**no dual EPI CE**); **HepA ≠ HepE**; **HepB ≠ HepE**; **HepC ≠ HepE**; WASH CE stays water; ORS ≠ HepE vaccine; cholera OCV/ICG ≠ HepE | **No** org ingest; drafts CE null / not_for_ranking; `cause_hepatitis_e` future-only; no medical dosing |
| **Hepatitis D / HDV co-infection programme systems** | WHO (HepD fact sheet; 2024 CHB guidelines HDV who/how/reflex; Global hepatitis report 2024); GiveWell — HepD Top Charity/CEA **honest null**; HLI/ACE honest null; IHME/GBD | Maps **no live HepD systems interventions** vs HBsAg+ co-infection testing, reflex diagnosis-access, dual B+D programme shape; **complementary** to Waves DC/HN HepB (**HepB ≠ HepD**; birth-dose CE stays HN); **HepC ≠ HepD**; **HepA ≠ HepD**; **HepE ≠ HepD**; Wave BZ immunization (**no dual EPI CE**) | **No** org ingest; drafts CE null / not_for_ranking; `cause_hepatitis_d` future-only; no medical dosing |
| **RSV maternal vaccine / long-acting mAb programme systems** | WHO (May 2025 position; SAGE Sep 2024; 30 May 2025 news); GiveWell — RSV Top Charity/CEA **honest null**; IHME/GBD; Gavi RSV maternal design-phase bibliography (Wave BZ owns Gavi) | Maps **no live RSV prevention systems interventions** vs maternal-vaccine introduction, long-acting mAb delivery, surveillance–targeting systems; **complementary** to Wave BZ immunization (**no dual EPI CE**); **pneumonia care ≠ RSV prevention**; **maternal EmONC ≠ RSV products**; **preterm ACS ≠ RSV**; **influenza ≠ RSV** | **No** org ingest; drafts CE null / not_for_ranking; `cause_rsv` future-only; no medical dosing |
| **Mumps vaccine introduction / catch-up / outbreak response systems** | WHO (March 2024 position; IVB; VPD surveillance); GiveWell — mumps Top Charity/CEA **honest null**; IHME/GBD; Gavi portfolio — mumps/MMR **not listed** (measles/MR ≠ MMR; Wave BZ owns Gavi) | Maps **no live mumps systems interventions** vs introduction/routine, catch-up/outbreak, surveillance–orchitis/complication systems; **complementary** to Wave BZ immunization (**no dual EPI CE**); **measles ≠ mumps**; **rubella/CRS ≠ mumps**; **varicella ≠ mumps**; MMR/MMRV bibliography only | **No** org ingest; drafts CE null / not_for_ranking; `cause_mumps` future-only; no medical dosing |
| **Seasonal influenza vaccine / programme systems** | WHO (May 2022 SAGE position; Global Influenza Strategy 2019–2030; toolkit; GISRS); GiveWell — seasonal influenza Top Charity/CEA **honest null**; IHME/GBD; Gavi portfolio — seasonal flu **not** current listed window (Wave BZ owns Gavi) | Maps **no live seasonal-flu systems interventions** vs risk-group routine, campaign/delivery, surveillance–vaccine-match systems; **complementary** to Wave BZ immunization (**no dual EPI CE**); **seasonal ≠ pandemic**; **pneumonia care ≠ flu vaccine** | **No** org ingest; drafts CE null / not_for_ranking; `cause_influenza` future-only; no medical dosing; no dual-use |
| **Maternal / neonatal tetanus (MNT) elimination systems** | WHO (MNTE strategies/progress; tetanus fact sheet; WER9206; Protecting-all); GiveWell — MNT Top Charity **honest null**; intervention report + UNICEF MNTE declined-review quarantine; IHME/GBD; Gavi TTCV adjacency bibliography (Wave BZ owns Gavi) | Maps **no live MNT systems interventions** vs Td-SIA HRD, clean delivery/cord, NT surveillance/validation; **complementary** to Wave BZ immunization (**no dual routine Td/TT EPI CE**) + Wave CB maternal (**no dual EmONC CE**); Wave FI neonatal sepsis sibling adjacency | **No** org ingest; drafts CE null / not_for_ranking; `cause_maternal_neonatal_tetanus` future-only; no medical dosing |
| **Pertussis (whooping cough) vaccine / outbreak systems** | WHO/SAGE (health topic; WER9035; SAGE WG; IVB; GHO); GiveWell — pertussis Top Charity/CEA **honest null** (NI Penta incidental Wave BZ); IHME/GBD; Gavi pentavalent/hexavalent/DTP-booster bibliography (Wave BZ owns Gavi) | Maps **no live pertussis systems interventions** vs primary-series intro/schedule-strengthening, booster/coverage catch-up, outbreak response campaign systems; **complementary** to Wave BZ immunization (**no dual EPI CE**; DTP–Penta stays immunization); **cross-links** MNT (≠ aP/wP) + Hib (Penta adjacency) + PCV/pneumonia (≠ pertussis vaccine) | **No** org ingest (no Gavi/manufacturers; NI immunization-only); drafts CE null / not_for_ranking; `cause_pertussis` future-only; no medical dosing |
| **Diphtheria vaccine / antitoxin programme systems** | WHO/SAGE (fact sheet; Aug 2017 position paper; IVB; AFRO outbreak guidance; DAT access/stockpile programme framing); GiveWell — dedicated diphtheria Top Charity / CEA **honest null**; IHME/GBD; Gavi penta/DTP-booster bibliography (Wave BZ owns Gavi) | Maps **no live diphtheria systems interventions** vs primary/booster introduction, outbreak campaign, DAT access/stockpile programme systems; **complementary** to Wave BZ immunization (**no dual routine-EPI CE**; DTP–Penta CE stays immunization); **MNT ≠ diphtheria** (Wave HR); **pertussis ≠ diphtheria** (Wave IO); **Hib ≠ diphtheria systems** (Wave HD) | **No** org ingest (no Gavi/DAT manufacturers; NI immunization-only); drafts CE null / not_for_ranking; `cause_diphtheria` future-only; no medical dosing / antitoxin reconstitution |
| **Childhood / adolescent / adult tetanus toxoid booster systems (beyond MNT)** | WHO/SAGE (fact sheet; WER9206; Protecting-all; IVB; MNTE strategies sustain); GiveWell — childhood-tetanus Top Charity/CEA **honest null** (NI Penta incidental Wave BZ; MNT report Wave HR quarantine); IHME/GBD; Gavi DTP-booster bibliography (Wave BZ owns Gavi) | Maps **no live childhood-tetanus booster systems** vs childhood booster introduction, school-age/adolescent catch-up, injury-prone adult booster programme systems; **complementary** to Wave HR MNT (**MNT ≠ childhood/adolescent/adult boosters**) + Wave BZ immunization (**no dual EPI CE**; DTP–Penta stays immunization); **pertussis ≠ tetanus boosters**; **diphtheria ≠ tetanus childhood boosters** | **No** org ingest (no Gavi/manufacturers; NI immunization-only); drafts CE null / not_for_ranking; `cause_tetanus_childhood` future-only; no medical dosing / wound-care how-to |
| **Hib conjugate vaccine systems** | WHO (position paper; IVB; standardization); GiveWell — dedicated Hib Top Charity / CEA **honest null**; IHME/GBD; Gavi pentavalent bibliography (Wave BZ owns Gavi) | Maps **no live Hib systems interventions** vs Hib conjugate introduction, catch-up/coverage-recovery, meningitis–pneumonia programme systems; **complementary** to Wave BZ immunization (**no dual routine-EPI CE**; Penta/Hib CE stays immunization); **Hib ≠ PCV** (pneumonia case management stays Wave DB); meningitis MenA ≠ Hib; measles/polio SIAs ≠ Hib intro | **No** org ingest (no Gavi/Hib Initiative; NI immunization-only); drafts CE null / not_for_ranking; `cause_hib` future-only; no medical dosing |
| **Cholera / oral cholera vaccine (OCV) systems** | WHO (fact sheet; ICG cholera stockpile; GTFCC Ending Cholera 2030); GiveWell — cholera/OCV CEA **honest null**; IHME/GBD; Gavi OCV portfolio bibliography (Wave BZ owns Gavi) | Maps **no live cholera systems interventions** vs OCV preventive campaigns, ICG emergency stockpile, outbreak surveillance systems; **complementary** to Wave CG diarrhea (**no dual ORS/zinc / thin OCV CE**); **cross-links** water (broader WASH) + immunization (OCV ≠ EPI CE) + YF (sibling ICG) + pandemic | **No** org ingest (no Gavi/UNICEF/MSF/IFRC/GTFCC); drafts CE null / not_for_ranking; `cause_cholera` future-only; no medical dosing |
| **Typhoid / typhoid conjugate vaccine (TCV) systems** | WHO (fact sheet; IVB; position papers; 2018 news); GiveWell — typhoid/TCV CEA **honest null**; IHME/GBD; Gavi TCV portfolio bibliography (Wave BZ owns Gavi) | Maps **no live typhoid systems interventions** vs TCV introduction, catch-up campaigns, outbreak-response systems; **complementary** to Wave CG diarrhea (**ORS/zinc ≠ TCV**) + Wave GV cholera (**OCV ≠ TCV**); **cross-links** immunization (no dual EPI CE) + water (WASH) + YF/JE + pandemic | **No** org ingest (no Gavi/UNICEF/TyVAC); drafts CE null / not_for_ranking; `cause_typhoid` future-only; no medical dosing |
| **Yellow fever vaccine / outbreak response systems** | WHO (fact sheet; IVB; EYE; ICG guidelines); GiveWell — YF CEA **honest null**; IHME/GBD; Gavi YF portfolio bibliography (Wave BZ owns Gavi) | Maps **no live YF interventions** vs vaccine introduction, PMVC, ICG emergency stockpile systems; **complementary** to Wave BZ immunization (**no dual routine-EPI CE**); **cross-links** JE (≠ YF) + dengue (owns Aedes IVM) + meningitis (≠ bacterial) + pandemic | **No** org ingest (no Gavi/UNICEF/MSF/IFRC; NI immunization-only); drafts CE null / not_for_ranking; `cause_yellow_fever` future-only; no medical dosing |
| **Dengue fever / Aedes-borne systems** | WHO (fact sheet; vaccines Q&A; May 2024 position; TAK-003 PQ; GVCR/GAI); GiveWell — dengue CEA **honest null**; Gavi VIS bibliography (Wave BZ owns Gavi); IHME/GBD | [`docs/cause-dengue-research.md`](../../docs/cause-dengue-research.md) | No new orgs; drafts CE null; complementary to JE (≠ dengue) + malaria (Anopheles ≠ Aedes) + immunization (no dual EPI CE); cross-link YF (Wave GQ) + chik/Zika (Wave GT); dengue keeps Aedes IVM; no medical dosing / vector-engineering SOPs |
| **Chikungunya / Zika Aedes-sibling systems** | WHO (chikungunya + Zika fact sheets; GAI); GiveWell — chik/Zika CEA **honest null**; IHME/GBD | [`docs/cause-chikungunya-zika-research.md`](../../docs/cause-chikungunya-zika-research.md) | No new orgs; drafts CE null; combined `cause_chikungunya_zika` future; complementary to dengue (owns Aedes IVM), YF (≠ chik/Zika), JE (Culex ≠ Aedes), immunization (no dual EPI CE); no medical dosing / pregnancy clinical how-to / vector-engineering SOPs |
| **Rabies PEP / dog vaccination systems (human rabies / One Health)** | WHO (fact sheet; Zero by 30; UAR; NTD roadmap); GiveWell — rabies CEA **honest null**; IHME/GBD bibliography; Gavi PEP support bibliography (Wave BZ owns Gavi) | Maps **no live rabies interventions** vs PEP access/readiness, dog MDV coverage, integrated bite-case surveillance; **complementary** to Wave BZ immunization (**no dual routine-EPI CE**; dog MDV ≠ human EPI CE); **cross-links** snakebite (antivenom ≠ RIG/PEP) + animal welfare (ACE ≠ human elimination) + pandemic (zoonosis only) | **No** org ingest (no Gavi/UAR/GARC; NI immunization-only; **no ACE ingest**); drafts CE null / not_for_ranking; `cause_rabies` future-only; **no PEP regimen / dosing how-to** |
| **Hearing loss / ear & hearing care** | WHO (fact sheet; World Report on Hearing 2021; H.E.A.R.I.N.G.); GiveWell — **no** dedicated hearing CEA / Top Charity (**honest thin-evidence**); IHME/Lancet GBD 2019 YLDs | Maps **no live hearing interventions** vs childhood/newborn screening, chronic otitis media sequelae, hearing-aids access, adult occupational conservation (LMIC); **cross-links** immunization (PCV/Hib — no vaccine CE duplicate) + pain/palliative (no palliative draft duplicate) | **No** org ingest; drafts CE null / not_for_ranking; `cause_hearing_loss` future-only; WHO ROI bibliography-only; no medical advice |
| **Chronic kidney disease / dialysis access** | WHO (fact sheet ~674M; WHA78.6 kidney health); GiveWell — **no** dedicated CKD/dialysis CEA / Top Charity (**honest thin-evidence**); IHME/Lancet GBD 2023 | Maps **no live CKD interventions** vs PHC early detection/case-finding, dialysis/KRT access, transplant + conservative care (LMIC); **cross-links** hypertension (**no salt-sub duplicate**) + diabetes (**no draft duplicate**) + pain (conservative QoL only) | **No** org ingest; drafts CE null / not_for_ranking; `cause_kidney_disease` future-only; WHO vs GBD prevalence quarantined; no medical advice |
| **Childhood cancer** | WHO (fact sheet; GICC ≥60% by 2030; CureAll framework); GiveWell — **no** dedicated childhood-cancer CEA / Top Charity (**honest thin-evidence**); IHME/GBD childhood-cancer DALYs | Maps **no live childhood-cancer interventions** vs early diagnosis/referral, essential medicines & treatment access, CureAll/GICC programme strengthening (LMIC); **cross-links** pain/palliative (**no morphine draft duplicate**); **disambiguates** cervical HPV / immunization HPV vaccine | **No** org ingest; drafts CE null / not_for_ranking; `cause_childhood_cancer` future-only; WHO cost-effective language quarantined; no medical advice / chemo protocols |
| **Stroke / cerebrovascular disease** | WHO (fact sheet; ACS–stroke framework 2024; HEARTS); GiveWell — **no** dedicated stroke / thrombolysis CEA / Top Charity (**honest thin-evidence**); adjacent GW salt pages stay HTN bibliography; IHME/GBD 2021 | Maps **no live stroke interventions** vs HTN-control prevention pathway shape, acute care & thrombolysis access, rehab/secondary-prevention access (LMIC); **cross-links** hypertension (**no salt-sub duplicate**) + diabetes + alcohol/tobacco (**no MPOWER duplicate**) + air-quality HAP | **No** org ingest; drafts CE null / not_for_ranking; `cause_stroke` future-only; no medical advice / thrombolysis protocols |
| **Ischemic heart disease / AMI / ACS** | WHO (heart-attack fact sheet IHD ~9M/2021; CVD fact sheet; ACS–stroke framework 2024; HEARTS); GiveWell — **no** dedicated IHD/AMI/ACS CEA / Top Charity (**honest thin-evidence**); adjacent GW salt pages stay HTN bibliography; IHME/GBD | Maps **no live IHD interventions** vs ACS/AMI acute-care access, post-ACS secondary-prevention & cardiac-rehab access, HEARTS primary pathway shape (LMIC); **cross-links** hypertension (**no salt-sub duplicate**) + stroke (**no thrombolysis duplicate**) + diabetes + RHD + CHD | **No** org ingest; drafts CE null / not_for_ranking; `cause_ischemic_heart_disease` future-only; no medical advice / PCI protocols |
| **Burns / thermal injury** | WHO (burns fact sheet; safer cookstoves/lamps; strengthen burn care; 2008 plan); GiveWell — **no** dedicated burns CEA / Top Charity (**honest thin-evidence**; clean cookstoves = HAP — air-quality owns); IHME/GBD burns bibliography | Maps **no live burns interventions** vs safer cookstoves/lamps (burn-injury prevention), first-aid access themes (**no** how-to), reconstructive care access; **cross-links** air-quality (**no HAP CE duplicate**) + road-safety trauma + pain/palliative | **No** org ingest; drafts CE null / not_for_ranking; `cause_burns` future-only; no medical advice / no first-aid how-to |
| **Osteoporosis / falls / fragility fracture** | WHO (falls ~684k/>80% LMIC; fragility fractures 2019; ageing & Decade/ICOPE); GiveWell — **no** dedicated falls/osteoporosis CEA / Top Charity (**honest thin-evidence**); IHME/GBD | Maps **no live falls/osteo interventions** vs older-adult fall prevention, fragility-fracture/bone-health access, LMIC ageing systems themes; **cross-links** road-safety (**no trauma/Zusha duplicate**) + burns + drowning + hypertension (fall-risk meds bibliography only) | **No** org ingest; drafts CE null / not_for_ranking; `cause_osteoporosis_falls` future-only; no medical dosing |
| **Rheumatic heart disease / ARF** | WHO (fact sheet; 2024 guideline; WHA71.14); GiveWell — **no** dedicated RHD CEA; IHME/NEJM GBD 2015 | Maps **no live RHD interventions** vs secondary prophylaxis (BPG), GAS pharyngitis primary prevention, thin valve-surgery access; **cross-links** hypertension (**no salt-sub**), maternal/fistula (**no EmONC**), syphilis (BPG commodity only) | **No** org ingest; drafts CE null / not_for_ranking; `cause_rheumatic_heart` future-only; no medical advice |
| **Acute rheumatic fever (ARF) primary prevention** | WHO (RHD fact sheet; 2024 guideline; WHA71.14); GiveWell — **no** dedicated ARF primary-prevention CEA (**honest null**); IHME/GBD | Maps **no live ARF primary interventions** vs school/community sore-throat systems, primordial living/housing, first-episode recognition/surveillance; **complementary** to Wave DM RHD (**keep** secondary/thin GAS/valve; **no dual CE**); **cross-links** IHD + CHD | **No** org ingest; drafts CE null / not_for_ranking; `cause_rheumatic_fever` future-only (or fold under RHD); no medical dosing |
|

**Wave FU (folded into 0.2.13):** Trachoma SAFE systems research pack — [`docs/cause-trachoma-research.md`](../../docs/cause-trachoma-research.md) · future `cause_trachoma` (complementary to vision ranking themes; CE null drafts; Sightsavers deworming-only).
**Wave GG (folded into 0.2.14):** Schisto morbidity / FGS / FSAC systems research pack — [`docs/cause-schisto-morbidity-research.md`](../../docs/cause-schisto-morbidity-research.md) · future `cause_schisto_morbidity` (complementary to Wave ER MDA/PC ownership; CE null drafts; no dual CE).

**Wave GD (folded into 0.2.14):** Postpartum sepsis / maternal infection IPC systems research pack — [`docs/cause-postpartum-sepsis-research.md`](../../docs/cause-postpartum-sepsis-research.md) · future `cause_postpartum_sepsis` (complementary to maternal EmONC ownership; CE null drafts; no dual CE with PPH/neonatal/syphilis).
**Wave GB (folded into 0.2.14):** Onchocerciasis systems research pack — [`docs/cause-onchocerciasis-research.md`](../../docs/cause-onchocerciasis-research.md) · future `cause_onchocerciasis` (complementary to Wave EV LF/oncho MDA/elimination; CE null drafts; Sightsavers deworming-only; no dual CE with LF MDA).

**Wave GE (folded into 0.2.14):** Thalassaemia / haemoglobinopathy systems research pack — [`docs/cause-thalassemia-research.md`](../../docs/cause-thalassemia-research.md) · future `cause_thalassemia` (complementary to sickle + anaemia; CE null drafts; GiveWell honest null; no dual CE with SCD NBS/transfusion; no chelation dosing).

**Wave GI (folded into 0.2.15):** Hepatitis C (HCV) treatment-access / DAA scale-up research pack — [`docs/cause-hepatitis-c-research.md`](../../docs/cause-hepatitis-c-research.md) · future `cause_hepatitis_c` (complementary to Wave DC hepatitis; CE null drafts; GiveWell honest null; no dual CE with HepB-BD / combined testing-treatment / blood-safety or cirrhosis; no DAA regimens as how-to).

**Wave GN (folded into 0.2.15):** Rabies PEP / dog vaccination systems research pack — [`docs/cause-rabies-research.md`](../../docs/cause-rabies-research.md) · future `cause_rabies` (complementary to Wave BZ + snakebite + animal welfare; CE null drafts; no dual EPI CE; no PEP how-to).

**Wave GT (folded into 0.2.15):** Chikungunya / Zika Aedes-sibling systems — [`docs/cause-chikungunya-zika-research.md`](../../docs/cause-chikungunya-zika-research.md) · future `cause_chikungunya_zika`.
**Wave GM (folded into 0.2.15):** Dengue / Aedes systems — [`docs/cause-dengue-research.md`](../../docs/cause-dengue-research.md) · future `cause_dengue`.

**Wave GK (folded into 0.2.15):** Japanese encephalitis / arboviral encephalitis vaccine systems research pack — [`docs/cause-japanese-encephalitis-research.md`](../../docs/cause-japanese-encephalitis-research.md) · future `cause_japanese_encephalitis` (complementary to Wave BZ; CE null drafts; no dual EPI CE).
**Wave GY (Unreleased post-0.2.15; QA pass landed):** Measles SIAs / outbreak response systems research pack — [`docs/cause-measles-research.md`](../../docs/cause-measles-research.md) · future `cause_measles` (complementary to Wave BZ; CE null drafts; no dual EPI CE).
**Wave GV (folded into 0.2.15):** Cholera / OCV systems research pack — [`docs/cause-cholera-research.md`](../../docs/cause-cholera-research.md) · future `cause_cholera` (complementary to Wave CG; CE null drafts; no dual ORS/thin OCV CE).
**Wave GQ (folded into 0.2.15):** Yellow fever vaccine / outbreak response systems research pack — [`docs/cause-yellow-fever-research.md`](../../docs/cause-yellow-fever-research.md) · future `cause_yellow_fever` (complementary to Wave BZ; CE null drafts; no dual EPI CE).

**Wave GW (Unreleased post-0.2.15; QA pass landed):** Typhoid / TCV systems — [`docs/cause-typhoid-research.md`](../../docs/cause-typhoid-research.md) · future `cause_typhoid`.

**Wave HG (Unreleased post-0.2.15; QA pass landed):** Rubella / CRS systems research pack — [`docs/cause-rubella-research.md`](../../docs/cause-rubella-research.md) · future `cause_rubella` (complementary to Wave BZ + Wave GY; CE null drafts; no dual EPI CE; CRS ≠ CZS).

**Wave GZ (Unreleased):** Polio / nOPV / cVDPV systems research pack — [`docs/cause-polio-research.md`](../../docs/cause-polio-research.md) · future `cause_polio` (complementary to Wave BZ; CE null drafts; no dual EPI CE).

**Wave HC (Unreleased post-0.2.15; QA pass landed):** Rotavirus / RVV systems research pack — [`docs/cause-rotavirus-research.md`](../../docs/cause-rotavirus-research.md) · future `cause_rotavirus` (complementary to diarrhea ORS/zinc ≠ RVV + immunization; CE null drafts; no dual EPI CE).



**Wave IB (Unreleased post-0.2.15; QA pass landed):** PMC / perennial malaria chemoprevention systems research pack — [`docs/cause-malaria-pmc-research.md`](../../docs/cause-malaria-pmc-research.md) · future `cause_malaria_pmc` (complementary to live malaria + HT SMC + HV IPTp + IA IRS; CE null drafts; SMC ≠ PMC ≠ IPTp ≠ IRS; no dual ITN/SMC CE).

**Wave IR (Unreleased post-0.2.15; QA pass landed):** IPTi / intermittent preventive treatment in infants systems research pack — [`docs/cause-malaria-ipti-research.md`](../../docs/cause-malaria-ipti-research.md) · future `cause_malaria_ipti` (complementary to live malaria + Wave IB PMC sibling + HT SMC + HV IPTp + IN CM; CE null drafts; IPTi ≠ SMC ≠ IPTp ≠ CM; no dual ITN/SMC/PMC CE).

**Wave IZ (Unreleased post-0.2.15; QA pass landed):** LF MDA / transmission interruption programme systems research pack — [`docs/cause-lf-mda-research.md`](../../docs/cause-lf-mda-research.md) · future `cause_lf_mda` (complementary to Wave EV thin `int_lf_mda` + Wave FZ MMDP ≠ MDA + Wave GB oncho ≠ LF MDA; CE null drafts; no dual CE with deworming).

**Wave IU (Unreleased post-0.2.15; QA pass landed):** Malaria MDA / mass screening-and-treatment programme systems research pack — [`docs/cause-malaria-mda-research.md`](../../docs/cause-malaria-mda-research.md) · future `cause_malaria_mda` (complementary to live malaria + HT SMC + HV IPTp + IB PMC + IR IPTi + IN CM; CE null drafts; MDA ≠ SMC ≠ IPTp ≠ PMC ≠ IPTi ≠ CM; no dual ITN/SMC CE).
**Wave IX (Unreleased post-0.2.15; QA pass landed):** Malaria IPTsc / school-age chemoprevention systems research pack — [`docs/cause-malaria-iptsc-research.md`](../../docs/cause-malaria-iptsc-research.md) · future `cause_malaria_iptsc` (complementary to live malaria + HT SMC + HV IPTp + IB PMC + IR IPTi + IU MDA + IN CM; CE null drafts; IPTsc ≠ SMC ≠ IPTp ≠ PMC ≠ IPTi ≠ MDA ≠ CM; no dual ITN/SMC CE).
**Wave JE (Unreleased post-0.2.15; QA pass landed):** Malaria RACD / reactive case detection systems research pack — [`docs/cause-malaria-racd-research.md`](../../docs/cause-malaria-racd-research.md) · future `cause_malaria_racd` (complementary to live malaria + IU MDA + IN CM + HT–IX chemoprevention + JB vivax; CE null drafts; RACD ≠ MDA mass ≠ CM care; no dual ITN/SMC CE).

**Wave IA (Unreleased post-0.2.15; QA pass landed):** IRS / indoor residual spray systems research pack — [`docs/cause-malaria-irs-research.md`](../../docs/cause-malaria-irs-research.md) · future `cause_malaria_irs` (complementary to live malaria + HT SMC + HV IPTp; CE null drafts; SMC ≠ IRS ≠ IPTp; no dual ITN/SMC CE).

**Wave HV (Unreleased post-0.2.15; QA pass landed):** IPTp / malaria in pregnancy systems research pack — [`docs/cause-malaria-iptp-research.md`](../../docs/cause-malaria-iptp-research.md) · future `cause_malaria_iptp` (complementary to live malaria + Wave HT SMC; CE null drafts; SMC ≠ IPTp; no dual ITN/SMC/EmONC CE).

**Wave HT (Unreleased post-0.2.15; QA pass landed):** Malaria SMC / seasonal chemoprevention systems research pack — [`docs/cause-malaria-smc-research.md`](../../docs/cause-malaria-smc-research.md) · future `cause_malaria_smc` (complementary to live malaria; CE null drafts; no dual SMC/ITN CE; pneumonia/maternal adjacency).
**Wave HP (Unreleased post-0.2.15; QA pass landed):** MenA / meningococcal conjugate vaccine systems research pack — [`docs/cause-meningococcal-research.md`](../../docs/cause-meningococcal-research.md) · future `cause_meningococcal` (complementary to Wave DU + Wave BZ; CE null drafts; no dual EPI CE; Hib ≠ MenA; PCV ≠ MenA).
**Wave HK (Unreleased post-0.2.15; QA pass landed):** PCV / pneumococcal conjugate vaccine systems research pack — [`docs/cause-pcv-research.md`](../../docs/cause-pcv-research.md) · future `cause_pcv` (complementary to Wave BZ; CE null drafts; no dual EPI CE; PCV ≠ care; Hib ≠ PCV).

**Wave HL (Unreleased post-0.2.15; QA pass landed):** HPV vaccine introduction / catch-up / vaccination-pillar systems research pack — [`docs/cause-hpv-research.md`](../../docs/cause-hpv-research.md) · future `cause_hpv` (complementary to Wave BZ + Wave CX; CE null drafts; no dual CE; HPV vaccine ≠ screening CE).
**Wave IF (Unreleased post-0.2.15; QA pass landed):** Varicella (chickenpox) / VZV vaccine introduction & catch-up systems research pack — [`docs/cause-varicella-research.md`](../../docs/cause-varicella-research.md) · future `cause_varicella` (complementary to Wave BZ + GY + HG; CE null drafts; no dual EPI CE; measles ≠ varicella; rubella ≠ varicella).

**Wave II (Unreleased post-0.2.15; QA pass landed):** Mumps vaccine introduction / catch-up / outbreak response systems research pack — [`docs/cause-mumps-research.md`](../../docs/cause-mumps-research.md) · future `cause_mumps` (complementary to Wave BZ + GY + HG + IF; CE null drafts; no dual EPI CE; measles ≠ mumps; rubella ≠ mumps; varicella ≠ mumps).
**Wave IL (Unreleased post-0.2.15; QA pass landed):** Hepatitis E vaccine / outbreak-response programme systems research pack — [`docs/cause-hepatitis-e-research.md`](../../docs/cause-hepatitis-e-research.md) · future `cause_hepatitis_e` (complementary to Wave BZ + IH + DC/HN + GI; CE null drafts; no dual EPI CE; HepA ≠ HepE; HepB ≠ HepE; HepC ≠ HepE; WASH CE stays water).
**Wave JC (Unreleased post-0.2.15; QA pass landed):** Hepatitis D / HDV co-infection programme systems research pack — [`docs/cause-hepatitis-d-research.md`](../../docs/cause-hepatitis-d-research.md) · future `cause_hepatitis_d` (complementary to DC/HN + GI + IH + IL + BZ; CE null drafts; HepB ≠ HepD; HepC ≠ HepD; HepA ≠ HepD; HepE ≠ HepD; no dual EPI CE).

**Wave IK (Unreleased post-0.2.15; QA pass landed):** RSV maternal vaccine / long-acting mAb programme systems research pack — [`docs/cause-rsv-research.md`](../../docs/cause-rsv-research.md) · future `cause_rsv` (complementary to Wave BZ + DB + CB + FH; CE null drafts; no dual EPI CE; care ≠ RSV prevention).
**Wave IJ (Unreleased post-0.2.15; QA pass landed):** Seasonal influenza vaccine / programme systems research pack — [`docs/cause-influenza-research.md`](../../docs/cause-influenza-research.md) · future `cause_influenza` (complementary to Wave BZ + CT + DB; CE null drafts; no dual EPI CE; seasonal ≠ pandemic; pneumonia care ≠ flu vaccine).
**Wave IH (Unreleased post-0.2.15; QA pass landed):** Hepatitis A (HAV) vaccine introduction / catch-up / outbreak systems research pack — [`docs/cause-hepatitis-a-research.md`](../../docs/cause-hepatitis-a-research.md) · future `cause_hepatitis_a` (complementary to Wave BZ + DC/HN + GI; CE null drafts; no dual EPI CE; HepB ≠ HepA; HepC ≠ HepA; WASH CE stays water).
**Wave IJ (Unreleased post-0.2.15; QA pass landed):** Seasonal influenza vaccine / programme systems research pack — [`docs/cause-influenza-research.md`](../../docs/cause-influenza-research.md) · future `cause_influenza` (complementary to Wave BZ + CT + DB; CE null drafts; no dual EPI CE; seasonal ≠ pandemic; pneumonia care ≠ flu vaccine).

**Wave HR (Unreleased post-0.2.15; QA pass landed):** Maternal / neonatal tetanus (MNT) elimination systems research pack — [`docs/cause-maternal-neonatal-tetanus-research.md`](../../docs/cause-maternal-neonatal-tetanus-research.md) · future `cause_maternal_neonatal_tetanus` (complementary to Wave BZ + Wave CB; CE null drafts; no dual EPI/EmONC CE).

**Wave IO (Unreleased post-0.2.15; QA pass landed):** Pertussis (whooping cough) vaccine / outbreak systems research pack — [`docs/cause-pertussis-research.md`](../../docs/cause-pertussis-research.md) · future `cause_pertussis` (complementary to Wave BZ; CE null drafts; no dual EPI CE; MNT ≠ aP/wP).

**Wave HD (Unreleased post-0.2.15; QA pass landed):** Hib conjugate vaccine systems research pack — [`docs/cause-hib-research.md`](../../docs/cause-hib-research.md) · future `cause_hib` (complementary to Wave BZ; CE null drafts; no dual EPI CE; Hib ≠ PCV).

**Wave IP (Unreleased post-0.2.15; QA pass landed):** Diphtheria vaccine / antitoxin programme systems research pack — [`docs/cause-diphtheria-research.md`](../../docs/cause-diphtheria-research.md) · future `cause_diphtheria` (complementary to Wave BZ; CE null drafts; no dual EPI CE; MNT ≠ diphtheria; pertussis ≠ diphtheria; Hib ≠ diphtheria systems).
**Wave IS (Unreleased post-0.2.15; QA pass landed):** Childhood / adolescent / adult tetanus toxoid booster systems beyond MNT research pack — [`docs/cause-tetanus-childhood-research.md`](../../docs/cause-tetanus-childhood-research.md) · future `cause_tetanus_childhood` (complementary to Wave HR MNT + Wave BZ; CE null drafts; MNT ≠ childhood boosters; no dual EPI CE).