# Human decision desk (Wave CA)
<!-- research_qa_passes: 125 -->

**Cut:** product_version **0.2.16** (Wave HZ/HE); **125** research QA passes at freeze; ADR 0007 **Proposed**; no auto-Accept / no ingest.

_Post-0.2.15 Unreleased research + defensibility waves (GW→JI / JH/JF/JG/…/IM) folded into **0.2.16**; historical "Unreleased post-0.2.15" labels below are archival until desk rewrite._

**One scannable list of every pending Ho Hum gate.** Agents draft; **Ho Hum decides**.  
This page consolidates ADR/policy Accepts, the exception review queue, and cause-research ingest approvals. It does **not** auto-resolve anything and does **not** Accept policies.

| Field | Value |
|-------|-------|
| Desk date | 2026-10-01 (ET) |
| Audience | Ho Hum (operator) · agents (read-only pointer) |
| Auto-resolve | **Never** |
| ADR 0007 | **Proposed** — Accept/Reject **only** via human stamp |
| Public hostname | **TBD** |

JSON-LD sidecar: [decision-desk.jsonld](decision-desk.jsonld).

Operator depth (approval questions): [`docs/cause-research-index.md`](../../docs/cause-research-index.md) · exception ops: [`docs/exception-review-ops.md`](../../docs/exception-review-ops.md) · STATUS: [`STATUS.md`](../../STATUS.md)

---

## Hard rules (agents)

- **No auto-resolve** — do not clear review items, flip cause `phase`, or invent Accepts.
- **Never mark ADR 0007 Accepted** — do not create `data/qa/human_stamps/adr_0007_accepted.by_ho_hum`.
- **No org ingest** from this desk — research packs stay bibliography until Ho Hum explicitly approves.
- **No invented CE** — leave null / `not_for_ranking` alone.
- **No domain registration / spend** from this tree.

---

## (A) ADR / policy — Accept/Reject only via human stamp

| Item | Status | What Ho Hum decides | Paths | Explicitly NOT done |
|------|--------|---------------------|-------|---------------------|
| **ADR 0007 — Cross-cause moral weights** | **Proposed** (awaiting Accept or revise) | Accept option (C)? Defer weight tables? Keep refusal for “single best charity in the world”? | [`docs/adr/0007-cross-cause-moral-weights.md`](../../docs/adr/0007-cross-cause-moral-weights.md) · [`docs/methodology-moral-weights.md`](../../docs/methodology-moral-weights.md) · `data/qa/moral_weights_policy.json` · `GET /v1/leaderboards` · CI: `scripts/check_adr_0007_human_stamp.py` | Agents must **not** Accept; product already ships separate leaderboards; `mixes_units_in_ranking: false`; no invented WELLBY↔life↔SAD↔tCO₂e factors; **CI fails** silent Accept without human stamp |

**How Ho Hum Accepts (only):** create `data/qa/human_stamps/adr_0007_accepted.by_ho_hum`, then flip ADR Status + policy `status` to Accepted. Agents must never create that stamp or treat Proposed as Accepted.

**Already settled (not pending):** ADR 0008 org-text prompt injection — **Accepted-as-mitigation-v1** (no further Accept needed for v1).

---

## (B) Review queue — read-only (2 open ACTRA items)

Live data: `data/review/queue.json` · API: **`GET /v1/review/queue`** (default open; `?status=all` for history) · human page: [review-queue.md](review-queue.md)

| ID | Severity | org_id | Status | One-line ask |
|----|----------|--------|--------|--------------|
| `exc_20261001_actra_donate` | high | `org_actra` | **open** | HTTP-verify (or intentionally mark) website + donate_url; update trust flags with evidence only |
| `exc_20261001_actra_claim_shallow` | medium | `org_actra` | **open** | Confirm UI/API never presents honourable-mention WELLBY claim as HLI Top Charity CE |

**Approve path:** offline edit of `data/review/queue.json` only — **no** write API. Agents must **never** auto-clear trust flags.

Open count: **2** · Approved (history): **3**

---


## (C) Research packs awaiting ingest approval (**125** with QA passes on live disk; **125** at **0.2.16** cut; **90** at **0.2.15** cut; **83** at **0.2.14** cut; **78** at 0.2.13 cut; **68** at 0.2.12 cut; **57** at 0.2.11 cut; **50** at 0.2.10 cut)

Shared status: `research_ready_awaiting_approval`. Public hub (research-only, not a ranking): [cause-research.md](cause-research.md). Full approval questions: [`docs/cause-research-index.md`](../../docs/cause-research-index.md).

| # | Cause | Primary evaluator(s) | Pack doc | Explicitly NOT done |
|---|-------|----------------------|----------|---------------------|
| 1 | **Animal welfare** | ACE (primary) | [`docs/cause-animal-welfare-research.md`](../../docs/cause-animal-welfare-research.md) | No org ingest; no SADs↔lives conversion |
| 2 | **Climate** | Giving Green / FP Climate | [`docs/cause-climate-research.md`](../../docs/cause-climate-research.md) | No org/fund ingest; no live climate CE |
| 3 | **US policy / advocacy** | Coefficient / OP Abundance & Growth + FP | [`docs/cause-us-policy-research.md`](../../docs/cause-us-policy-research.md) | No org ingest; never auto-rank vs GiveWell $/life |
| 4 | **Mental health / wellbeing (expansion)** — incl. Shamiri / ACTRA Honourable Mentions | HLI (primary) | [`docs/cause-mental-health-research.md`](../../docs/cause-mental-health-research.md) | **No new** orgs; Phase 1 HLI Top/Promising stay live; expansion bibliography-only |
| 5 | **GCR / x-risk** | FP GCR / Longview / GWWC / Coefficient | [`docs/cause-gcr-research.md`](../../docs/cause-gcr-research.md) | No org ingest; no CE / risk-probability BOTE; info-hazard high-level only |
| 6 | **Lead / education** | HLI Pure Earth (live) + GW / FP (LEEP, TaRL, Imagine) | [`docs/cause-lead-education-research.md`](../../docs/cause-lead-education-research.md) | No new orgs; LEEP/TaRL/Imagine gated |
| 7 | **Acute poisoning / toxic exposures** | WHO (poison centres; pesticides; household pesticides; HAP kerosene-ingestion); GiveWell — CPSP **cite-only** + **honest null** acute unintentional CEA; LEEP stays lead; IHME GBD | [`docs/cause-poisoning-research.md`](../../docs/cause-poisoning-research.md) | No new orgs (no CPSP/poison-centre NGOs); drafts CE null; cross-link lead (LEEP) + snakebite (no dual CE) + burns (ingestion ≠ flame) + road-safety; info-hazard high-level; no medical dosing |
| 8 | **Family planning / reproductive health** | GiveWell (+ FP/GWWC FEM bibliography) | [`docs/cause-family-planning-research.md`](../../docs/cause-family-planning-research.md) | No org ingest; draft CE null; sensitive-topic safeguards |
| 9 | **Air quality (HAP / cookstoves)** | GiveWell / WHO / Berkeley Air | [`docs/cause-air-quality-research.md`](../../docs/cause-air-quality-research.md) | No org ingest; no double-count with climate |
| 10 | **Poverty / cash / income (expansion)** | GiveWell + GiveDirectly (live) + HLI cash | [`docs/cause-poverty-cash-research.md`](../../docs/cause-poverty-cash-research.md) | No new orgs; pilots gated; CE null on drafts |
| 11 | **Safe water / sanitation (expansion)** | GiveWell + Evidence Action Safe Water (live) | [`docs/cause-water-sanitation-research.md`](../../docs/cause-water-sanitation-research.md) | No new orgs; RFI partners gated |
| 12 | **Deworming / NTD (expansion)** | GiveWell + Evidence Action DtW (live) | [`docs/cause-deworming-ntd-research.md`](../../docs/cause-deworming-ntd-research.md) | No new orgs; no END Fund ingest; former-top vs current stance flagged |
| 13 | **Nutrition / micronutrient fortification (expansion)** | GiveWell + HLI (Helen Keller / Fortify / EA IFA / Taimaka live) | [`docs/cause-nutrition-research.md`](../../docs/cause-nutrition-research.md) | No new orgs; MMS/iodization/rice/Africa RFI gated |
| 14 | **Immunization / vaccines (expansion)** | GiveWell (New Incentives live; IRD/Suvita/RFI/measles/HPV bibliography) | [`docs/cause-immunization-research.md`](../../docs/cause-immunization-research.md) | No new orgs (NI/PATH/MC live); Gavi bibliography-only; CE null |
| 15 | **Malaria (ITNs / SMC / seasonal expansion)** | GiveWell (AMF ITNs + MC SMC live; PATH vaccine/PMC bibliography) | [`docs/cause-malaria-research.md`](../../docs/cause-malaria-research.md) | No new orgs (AMF/MC/PATH live); vaccines bibliography-only; PMC/IRS drafts gated |
| 16 | **Tuberculosis (TB)** | GiveWell (TB HCM / IPT–TPT; mass ACF; CHAI/Spiro bibliography; TB cells bibliography-only) | [`docs/cause-tuberculosis-research.md`](../../docs/cause-tuberculosis-research.md) | No TB orgs live; no CHAI/Spiro ingest; drafts CE null; never conflate with `int_group_ipt`; cells bibliography-only |
| 17 | **Maternal / neonatal health** | GiveWell (Ansh KMC + EA syphilis live; PLA-MNH / fistula / Safe Motherhood bibliography) | [`docs/cause-maternal-neonatal-research.md`](../../docs/cause-maternal-neonatal-research.md) | No new orgs (Ansh/EA syphilis live); no Fistula Foundation ingest; MMS stays nutrition; CE null |
| 18 | **Congenital syphilis / antenatal STI** | GiveWell (syphilis screen/treat; EA Liberia + Zambia–Cameroon dual-test grants; Liberia lookback; **cells bibliography-only**); WHO (dual RDTs; triple elimination) | [`docs/cause-syphilis-research.md`](../../docs/cause-syphilis-research.md) | No new orgs (EA syphilis live); drafts CE null; cross-link maternal + HIV (no PrEP/ART duplicate); no medical advice |
| 19 | **Diarrhea / ORS / cholera** | GiveWell (ORS/zinc report; CHAI/Clear Solutions/NI ORSZ grants; JHU CHoBI7; cells bibliography-only) | [`docs/cause-diarrhea-research.md`](../../docs/cause-diarrhea-research.md) | No new orgs (do not duplicate NI-ORS / EA water); drafts CE null; cross-link water + immunization; OCV thin |
| 20 | **Childhood pneumonia / ARI** | GiveWell (iCCM; R4D amox-DT + lookback; new-areas oxygen/pulse-ox; **cells bibliography-only**); WHO / IHME | [`docs/cause-pneumonia-research.md`](../../docs/cause-pneumonia-research.md) | No new orgs (no R4D/IRC/PATH oxygen-arm; do not duplicate NI); drafts CE null; PCV/Hib stay immunization; HAP air-quality; diarrhea separate |
| 21 | **HIV / AIDS** | GiveWell (oral PrEP; VMMC; ART/treatment support; HIV cells bibliography-only; 2025–26 reassessment) | [`docs/cause-hiv-research.md`](../../docs/cause-hiv-research.md) | No HIV orgs live; no PIH/Jhpiego/PSI ingest; drafts CE null; cells bibliography-only; no medical advice |
| 22 | **Pain / palliative care** | HLI (Pain Exploration 3; Pallium BOTECs bibliography-only; Giving Season in progress); GiveWell N/A | [`docs/cause-pain-palliative-research.md`](../../docs/cause-pain-palliative-research.md) | No pain orgs live; no Pallium/HAU/DSF ingest; drafts CE null; BOTECs bibliography-only; no medical advice; cross-link MH palliative stub |
| 23 | **Vision / trachoma / blindness** | GiveWell (SAFE trachoma — dated; cataract + IDinsight hold; cataract BOTE cells bibliography-only) | [`docs/cause-vision-research.md`](../../docs/cause-vision-research.md) | No new orgs (do not duplicate Sightsavers; no Fred Hollows/Seva/CBM); drafts CE null; cross-link deworming NTD + Wave EO glaucoma/DR (no SAFE/cataract move) + Wave FU trachoma systems (no dual CE); cells bibliography-only |
| 24 | **Trachoma SAFE systems** | WHO (trachoma fact sheet SAFE S/A/F/E; TT backlog / MDA counts bibliography; SAFE leadership; trichiasis manuals); GiveWell dated SAFE **cite-only** (Wave CO owns ranking + thin SAFE/cataract stubs); systems **honest null**; IHME/GBD | [`docs/cause-trachoma-research.md`](../../docs/cause-trachoma-research.md) | No new orgs (no ITI/Fred Hollows/Seva/CBM; Sightsavers deworming-only); drafts CE null; complementary to vision (no dual CE) + deworming + LF/oncho + yaws + WASH; no medical dosing |
| 25 | **Skin NTDs (scabies / yaws / leprosy)** | GiveWell (scabies ivermectin MDA — Sep 2021; CEA cells bibliography-only / below bar); WHO skin-NTD / yaws / leprosy | [`docs/cause-skin-ntd-research.md`](../../docs/cause-skin-ntd-research.md) | No new orgs (do not duplicate Sightsavers; no WSEP/ILEP/Lepra); drafts CE null; cross-link deworming + vision; cells bibliography-only |
| 26 | **Hypertension / cardiovascular** | GiveWell (dietary salt modification; community salt substitution; nutrition strategy CVD; PH-regulation sodium vs lead; cells bibliography-only) | [`docs/cause-hypertension-research.md`](../../docs/cause-hypertension-research.md) | No new orgs (do not duplicate Pure Earth; RTSL Phase 1 scoping already live — no silent HTN tag expand; no WASH ingest); drafts CE null; cross-link lead + air-quality; cells bibliography-only |
| 27 | **Diabetes / metabolic NCD** | WHO Compact/HEARTS-D/fact sheet + IHME GBD; GiveWell context only (nutrition H2; NCD Best Buys PDF — no deep diabetes CEA) | [`docs/cause-diabetes-research.md`](../../docs/cause-diabetes-research.md) | No new orgs; drafts CE null; cross-link hypertension (no salt-sub duplicate); HAP→CVD stays air-quality; Wave EO owns glaucoma+DR treatment-access (screening stub stays diabetes); WHO/GBD bibliography-only; ADR 0007 Proposed |
| 28 | **Pandemic / biosecurity preparedness** | Coefficient biosecurity; FP biosecurity/GCBR/GCR Fund; GWWC R&R; 80k framing | [`docs/cause-pandemic-preparedness-research.md`](../../docs/cause-pandemic-preparedness-research.md) | No biosecurity orgs live; no SecureBio/IBBIS/Blueprint/CHS ingest; drafts CE null; info-hazard high-level only; cross-link GCR biosecurity stub |
| 29 | **Road safety / traffic injury** | GiveWell (Zusha! standout — discontinued; CEA cells bibliography-only; 2009 DCP speed/speed-bumps pointer; 2019 AIP helmets — not selected); WHO / IHME burden | [`docs/cause-road-safety-research.md`](../../docs/cause-road-safety-research.md) | No new orgs (no gui2de/Zusha!/AIP); drafts CE null; cross-link maternal/lead/air; cells bibliography-only |
| 30 | **Cervical cancer / HPV** | GiveWell (HPV vaccine context only); WHO screen-and-treat / 90–70–90; **Gavi bibliography-only** | [`docs/cause-cervical-hpv-research.md`](../../docs/cause-cervical-hpv-research.md) | No new orgs (no Gavi/CHAI/PATH); drafts CE null; cross-link immunization HPV draft; no medical advice |
| 31 | **Hepatitis B / C** | WHO (HepB/HepC/blood-safety; Global hepatitis report 2026); GiveWell (NI pentavalent/HepB BD cross-link only — no dedicated Hep CEA); **Gavi bibliography-only** | [`docs/cause-hepatitis-research.md`](../../docs/cause-hepatitis-research.md) | No new orgs (no Gavi/CHAI/Unitaid); drafts CE null; cross-link immunization vaccine CE; HIV co-infection notes only; no medical advice |
| 32 | **Cirrhosis / chronic liver disease** | WHO (HepB/HepC; Global hepatitis report 2026; alcohol co-driver; no dedicated cirrhosis sheet); GiveWell — **no** dedicated cirrhosis/CLD CEA / Top Charity; IHME/GBD 2021 | [`docs/cause-cirrhosis-research.md`](../../docs/cause-cirrhosis-research.md) | No new orgs; drafts CE null; cross-link hepatitis (no HepB-BD/DAA duplicate) + alcohol-tobacco (no SAFER/RESET duplicate); no medical protocols |
| 33 | **Alcohol harm / tobacco control** | GiveWell (RESET Alcohol — BOTEC bibliography-only; PH-regulation tobacco deprioritized); WHO SAFER/MPOWER best buys; IHME burden | [`docs/cause-alcohol-tobacco-research.md`](../../docs/cause-alcohol-tobacco-research.md) | No new orgs (no Vital Strategies/RESET/CTFK); drafts CE null; cross-link HTN/diabetes (no salt-sub); cells bibliography-only |
| 34 | **Drowning / child water safety** | WHO (fact sheet; Guideline day-care + swim skills; practical guidance); IHME GBD; GiveWell — **no** dedicated drowning CEA | [`docs/cause-drowning-research.md`](../../docs/cause-drowning-research.md) | No new orgs (no CIPRB/SwimSafe/Bloomberg drowning); drafts CE null; cross-link road-safety trauma + safe-water/WASH; WHO investment-case bibliography-only |
| 35 | **Snakebite envenoming** | WHO (fact sheet; 2019 strategy; antivenoms access); GiveWell (Dec 2022 open-thread — 2017 below-bar unpublished assessment; **bibliography-only**); IHME Nature Comm 2022 mortality/YLLs | [`docs/cause-snakebite-research.md`](../../docs/cause-snakebite-research.md) | No new orgs (no Wellcome/MSF/GSI/manufacturers; do not expand Sightsavers); drafts CE null; cross-link skin-NTD + deworming/NTD; no medical advice |
| 36 | **Obstetric fistula** | GiveWell (fistula surgery Dec 2021 — **below funding bar**; BOTE bibliography-only); WHO (facts-in-pictures; timely obstetric care / EmONC framing) | [`docs/cause-fistula-research.md`](../../docs/cause-fistula-research.md) | No new orgs (no Fistula Foundation/Hamlin/EngenderHealth); drafts CE null; cross-link maternal (no EmONC CE duplicate); no medical advice |
| 37 | **Sickle cell disease** | WHO (fact sheet; childhood guideline; AFRO strategy/PEN-Plus); GiveWell — **no** dedicated SCD CEA / Top Charity; IHME GBD 2021 | [`docs/cause-sickle-cell-research.md`](../../docs/cause-sickle-cell-research.md) | No new orgs; drafts CE null; cross-link malaria (no ITN/SMC/PMC CE duplicate) + maternal + immunization; no medical advice |
| 38 | **Rheumatic heart disease / ARF** | WHO (fact sheet; 2024 guideline; WHA71.14; PEN-Plus bibliography); GiveWell — **no** dedicated RHD CEA; IHME/NEJM GBD 2015 burden | [`docs/cause-rheumatic-heart-research.md`](../../docs/cause-rheumatic-heart-research.md) | No new orgs (no WHF/Reach/surgery NGOs); drafts CE null; cross-link HTN (no salt-sub); maternal/fistula (no EmONC); syphilis BPG commodity only; Wave FT ARF primary complementary (no dual CE); no medical advice |
| 39 | **Hearing loss / ear & hearing care** | WHO (fact sheet; World Report on Hearing 2021; H.E.A.R.I.N.G.); GiveWell — **no** dedicated hearing CEA / Top Charity; IHME/Lancet GBD 2019 YLDs | [`docs/cause-hearing-loss-research.md`](../../docs/cause-hearing-loss-research.md) | No new orgs (no manufacturers/EHC NGOs; do not expand New Incentives); drafts CE null; WHO ROI bibliography-only; cross-link immunization PCV + pain (no vaccine/palliative duplicate); no medical advice |
| 40 | **Burns / thermal injury** | WHO (fact sheet; safer cookstoves/lamps; strengthen burn care; 2008 plan); GiveWell — **no** dedicated burns CEA / Top Charity; IHME/GBD | [`docs/cause-burns-research.md`](../../docs/cause-burns-research.md) | No new orgs; drafts CE null; cross-link air-quality (no HAP CE duplicate) + road-safety trauma + pain; no medical advice / no first-aid how-to |
| 41 | **Noma / severe oral-facial gangrene & oral health** | WHO (fact sheet; Dec 2023 NTD listing; oral-health co-mention); GiveWell — **no** dedicated noma CEA / Top Charity; IHME/GBD noma not computed | [`docs/cause-noma-research.md`](../../docs/cause-noma-research.md) | No new orgs (no MSF noma entities/Hilfsaktion/Facing Africa); drafts CE null; WHO 1998 burden bibliography-only; cross-link nutrition (no VAS/CMAM CE) + skin-NTD (platform only) + maternal/fistula (no EmONC) + Wave EM oral health (complementary); no medical advice |
| 42 | **Epilepsy / seizure disorders** | WHO (fact sheet; IGAP 2022–2031; mhGAP-IG; technical brief); GiveWell — **no** dedicated epilepsy / phenobarbital CEA / Top Charity; IHME/Lancet Public Health GBD 2021 | [`docs/cause-epilepsy-research.md`](../../docs/cause-epilepsy-research.md) | No new orgs (no ILAE/IBE implementers/ASM manufacturers); drafts CE null; cross-link MH (no IPT duplicate) + pain (no palliative duplicate); no medical advice / ASM dosing |
| 43 | **Chronic kidney disease / dialysis access** | WHO (fact sheet; WHA78.6); GiveWell — **no** dedicated CKD/dialysis CEA / Top Charity; IHME/Lancet GBD 2023 | [`docs/cause-kidney-disease-research.md`](../../docs/cause-kidney-disease-research.md) | No new orgs (no ISN/dialysis NGOs); drafts CE null; cross-link hypertension (no salt-sub duplicate) + diabetes (no draft duplicate) + pain (conservative QoL only); no medical advice |
| 44 | **Depression / CMD treatment-gap** | WHO (depression; mhGAP; Action Plan); GiveWell — **no** dedicated mhGAP/CMD-systems CEA / Top Charity; HLI context (WELLBY stays MH); IHME/Lancet MAT ~9.1% | [`docs/cause-depression-treatment-gap-research.md`](../../docs/cause-depression-treatment-gap-research.md) | No new orgs; drafts CE null; complementary to MH HLI Shamiri/ACTRA (**no charity CE duplicate**); cross-link epilepsy + Wave EP autism/NDD + pain; no WELLBY↔DALY mixes; no medical dosing |
| 45 | **Meningitis / meningococcal disease** | WHO (fact sheet; Defeating Meningitis by 2030; AFRO belt; MenAfriVac/Men5CV shape); GiveWell Meningitis A (2016) — **RFMF-stop / incomplete investigation** (no completed CEA/Top Charity); IHME/GBD 2023 | [`docs/cause-meningitis-research.md`](../../docs/cause-meningitis-research.md) | No new orgs (no Gavi/MVP/ICG as meningitis orgs; do not expand New Incentives); drafts CE null; cross-link immunization PCV/Hib/MenA (no vaccine CE duplicate) + hearing sequelae notes only; no medical advice |
| 46 | **Childhood cancer** | WHO (fact sheet; GICC; CureAll); GiveWell — **no** dedicated childhood-cancer CEA / Top Charity; IHME/GBD | [`docs/cause-childhood-cancer-research.md`](../../docs/cause-childhood-cancer-research.md) | No new orgs (no St. Jude/SIOP/CCI); drafts CE null; cross-link pain (no palliative duplicate); disambiguate cervical HPV; no medical advice / chemo protocols |
| 47 | **Asthma / COPD / chronic respiratory disease** | WHO (asthma; COPD; CRD topic; PEN); GiveWell — **no** dedicated asthma/COPD / inhaler CEA / Top Charity; IHME/GBD 2021 | [`docs/cause-asthma-copd-research.md`](../../docs/cause-asthma-copd-research.md) | No new orgs; drafts CE null; cross-link air-quality (no HAP CE duplicate) + alcohol-tobacco (no MPOWER duplicate) + pneumonia; no medical dosing |
| 48 | **Stroke / cerebrovascular disease** | WHO (fact sheet; ACS–stroke framework; HEARTS); GiveWell — **no** dedicated stroke / thrombolysis CEA / Top Charity; IHME/GBD 2021 | [`docs/cause-stroke-research.md`](../../docs/cause-stroke-research.md) | No new orgs (no WSO/WHF/national foundations); drafts CE null; cross-link hypertension (no salt-sub duplicate) + diabetes + alcohol/tobacco (no MPOWER duplicate); no medical advice / thrombolysis protocols |
| 49 | **Anaemia / iron deficiency (LMIC multi-etiology)** | WHO (fact sheet; accelerating framework; 2025 estimates); GiveWell iron fortification/IFA/Africa RFI/podcast (**cite-only — nutrition owns CE**); IHME/GBD | [`docs/cause-anemia-research.md`](../../docs/cause-anemia-research.md) | No new orgs (do not duplicate Fortify/EA IFA/Helen Keller); drafts CE null; cross-link nutrition (no IFA/fortification/MMS/VAS duplicate) + maternal + malaria (no ITN/SMC) + deworming (no MDA); no medical dosing |
| 50 | **Osteoporosis / falls / fragility fracture** | WHO (falls; fragility fractures; ageing & Decade/ICOPE); GiveWell — **no** dedicated falls/osteoporosis CEA / Top Charity; IHME/GBD | [`docs/cause-osteoporosis-falls-research.md`](../../docs/cause-osteoporosis-falls-research.md) | No new orgs (no IOF/FFN/manufacturers); drafts CE null; cross-link road-safety (no trauma/Zusha duplicate) + burns + drowning + hypertension (fall-risk meds bibliography only); no medical dosing |
| 51 | **Iodine deficiency / USI / goiter** | WHO (salt-iodization guideline; IDD assessment guide; systematic review); GiveWell salt iodization (**cite-only — nutrition owns CE draft**); IHME/GBD | [`docs/cause-iodine-deficiency-research.md`](../../docs/cause-iodine-deficiency-research.md) | No new orgs (do not duplicate IGN); drafts CE null; cross-link nutrition (no VAS/IFA/salt-iodization-draft duplicate) + anaemia (stay separate) + HTN (salt-CVD stays HTN); no medical dosing |
| 52 | **Congenital heart disease / pediatric cardiac** | WHO (congenital disorders fact sheet; newborn screening; surgery mitigates CHD lethality; no dedicated CHD-only sheet); GiveWell — **no** dedicated CHD CEA / Top Charity; IHME/Lancet GBD 2017 | [`docs/cause-congenital-heart-disease-research.md`](../../docs/cause-congenital-heart-disease-research.md) | No new orgs (no Children’s HeartLink/Global ARCH/HeartGift); drafts CE null; CHD ≠ RHD (no RF prophylaxis duplicate); cross-link maternal (no EmONC); no medical/surgical protocols |
| 53 | **Vitamin D deficiency / nutritional rickets** | WHO (2025 oils/fats A+D guideline; 2019 rickets review; eLENA infants **404**); GiveWell — **no** VDD/rickets CEA (**honest null**; VAS cite-only A≠D — nutrition owns); IHME/GBD | [`docs/cause-vitamin-d-rickets-research.md`](../../docs/cause-vitamin-d-rickets-research.md) | No new orgs; drafts CE null; cross-link nutrition (no VAS/IFA/MMS/iron/iodization-draft duplicate) + anaemia + iodine (stay separate) + maternal + osteo; no medical dosing |
| 54 | **Obstructive sleep apnea / sleep-disordered breathing** | WHO (ICD-11 Ch.07 Sleep–wake; no dedicated OSA fact sheet — honest gap; HTN/diabetes co-morbidity cross-link); GiveWell — **no** dedicated OSA/CPAP CEA / Top Charity (**never invent CPAP CE**); Benjafield 2019 (~936M/~425M prevalence — not GBD); IHME GBD OSA fact sheet not found | [`docs/cause-sleep-apnea-research.md`](../../docs/cause-sleep-apnea-research.md) | No new orgs (no sleep foundations/CPAP manufacturers); drafts CE null; cross-link HTN (no salt-sub) + diabetes (no metabolic) + asthma/COPD (OSA ≠ CRD) + stroke + road-safety (drowsy-driving linkage only); no medical dosing / device protocols |
| 55 | **Oral health beyond noma (caries / periodontal / fluoride)** | WHO (oral-health fact sheet ~3.7B; GOHAP); GiveWell — **no** dedicated oral-health/fluoride CEA (**honest thin-evidence**); IHME/Lancet GBD 2021 | [`docs/cause-oral-health-research.md`](../../docs/cause-oral-health-research.md) | No new orgs; drafts CE null; complementary to noma (Wave DS); fluoride bibliography-only (no dosing); cross-link nutrition/water/AT/diabetes |
| 56 | **Glaucoma / diabetic retinopathy** | WHO (blindness/vision fact sheet; glaucoma ~7.7M / DR ~3.9M; World report on vision / IPEC); GiveWell — **no** dedicated glaucoma/DR CEA (**honest null**; cataract/SAFE cite-only — vision owns); IHME/VLEG/GBD | [`docs/cause-glaucoma-retinopathy-research.md`](../../docs/cause-glaucoma-retinopathy-research.md) | No new orgs (no Fred Hollows/Seva/CBM/Orbis; do not expand Sightsavers); drafts CE null; cross-link vision (no SAFE/cataract duplicate) + diabetes (glycemic + screening stub stay diabetes); WHO 411B bibliography-only; no medical dosing/laser protocols |
| 57 | **Autism / NDD support & early identification** | WHO (autism fact sheet ~1 in 127/2021; CST; WHO–UNICEF Global report; WHA67.8); GiveWell — **no** dedicated autism/NDD/CST CEA (**honest null**; **no cure**); IHME/Lancet Psychiatry GBD 2021 | [`docs/cause-autism-ndd-research.md`](../../docs/cause-autism-ndd-research.md) | No new orgs (no autism foundations/ABA/CST implementers); drafts CE null; cross-link MH (no Shamiri/ACTRA/IPT duplicate) + depression (no mhGAP-depression) + epilepsy (no AED); no behavioural-therapy protocols |
| 58 | **Dementia / Alzheimer / cognitive ageing** | WHO (dementia fact sheet; iSupport; Global action plan →2031; GDO); GiveWell — **no** dedicated dementia/Alzheimer/caregiver CEA / Top Charity (**honest null**; no cure / no disease-modifying CE); IHME/GBD ADOD | [`docs/cause-dementia-research.md`](../../docs/cause-dementia-research.md) | No new orgs (no ADI/national societies/manufacturers); drafts CE null; cross-link depression (no mhGAP depression duplicate) + stroke (no acute-care duplicate) + falls/ageing + pain (no morphine); no medical dosing / diagnostic how-to |
| 59 | **Schistosomiasis (bilharzia)** | WHO (fact sheet; 2022 guideline; NTD road map); GiveWell — dated schisto MDA + combination deworming (**cite-only**; DCP2 quarantined); IHME GBD/GHDx | [`docs/cause-schistosomiasis-research.md`](../../docs/cause-schistosomiasis-research.md) | No new orgs (no END Fund; do not duplicate DtW/Unlimit/Sightsavers); drafts CE null; complementary to deworming (no STH/combination CE duplicate); cross-link water (chlorination ≠ snail/WASH) + skin-NTD + anaemia; no medical dosing |
| 60 | **Ischemic heart disease / AMI / ACS** | WHO (heart-attack fact sheet; CVD fact sheet; ACS–stroke framework; HEARTS); GiveWell — **no** dedicated IHD/AMI/ACS CEA / Top Charity; IHME/GBD | [`docs/cause-ischemic-heart-disease-research.md`](../../docs/cause-ischemic-heart-disease-research.md) | No new orgs (no WHF/cardiology societies/manufacturers); drafts CE null; cross-link hypertension (no salt-sub duplicate) + stroke (no thrombolysis duplicate) + diabetes + RHD + CHD; no medical advice / PCI protocols |
| 61 | **Lymphatic filariasis / onchocerciasis** | WHO (LF fact sheet; MMDP; GPELF progress; oncho fact sheet; stop-MDA; NTD road map); GiveWell — dated LF + river-blindness MDA (**cite-only**; DCP2 quarantined); IHME GBD | [`docs/cause-lf-onchocerciasis-research.md`](../../docs/cause-lf-onchocerciasis-research.md) | No new orgs (no Carter Center/END Fund/Merck; do not duplicate DtW/Unlimit/Sightsavers); drafts CE null; complementary to deworming (no STH/combination CE duplicate); cross-link vision (trachoma ≠ oncho) + skin-NTD + schisto; no medical dosing |
| 62 | **Onchocerciasis (river blindness) systems** | WHO (oncho fact sheet CDTI/APOC; ≥80% coverage; Simulium; ocular/skin sketches; progress; stop-MDA/OEM); GiveWell dated river-blindness **cite-only** (Wave EV owns MDA + thin oncho MDA stub); systems **honest null**; IHME/GBD | [`docs/cause-onchocerciasis-research.md`](../../docs/cause-onchocerciasis-research.md) | No new orgs (no Carter Center/END Fund/Merck; Sightsavers deworming-only); drafts CE null; complementary to Wave EV LF/oncho (no dual CE with LF MDA) + deworming + trachoma/vision + LF MMDP doc; no medical dosing |
| 63 | **LF MMDP / hydrocele / lymphedema systems** | WHO (MMDP minimum package; ~40M manifestations; 2019 surgical approaches; GPELF progress); GiveWell — dated LF MDA **cite-only** (Wave EV) + MMDP systems **honest null**; IHME GBD | [`docs/cause-lf-mmdp-research.md`](../../docs/cause-lf-mmdp-research.md) | No new orgs (no Carter Center/END Fund; Sightsavers deworming-only); drafts CE null; complementary to LF/oncho (no dual CE) + skin/leprosy/Buruli + trachoma (TT ≠ hydrocele); no medical dosing / surgical how-to |
| 122 | **LF MDA / transmission interruption programme systems** | WHO (GPELF MDA; fact sheet; progress 2024; monitoring manual 2025 TAS/EMS/IDA/PVS; GHO); GiveWell dated LF MDA **cite-only** (Wave EV thin `int_lf_mda`) + LF MDA Top Charity / refreshed CEA **honest null**; IHME GBD | [`docs/cause-lf-mda-research.md`](../../docs/cause-lf-mda-research.md) | No new orgs (no Carter Center/END Fund/Merck; Sightsavers deworming-only); drafts CE null; complementary to Wave EV (no dual CE) + Wave FZ MMDP ≠ MDA + Wave GB oncho ≠ LF MDA; no medical dosing / IDA regimen how-to |
| 64 | **COPD exacerbation / chronic respiratory care pathway** | WHO (COPD fact sheet — flare-ups/oxygen/rehab; rehab Module 4); GiveWell — **no** dedicated COPD-exacerbation / pulmonary-rehab / LTOT CEA / Top Charity; IHME/GBD | [`docs/cause-copd-exacerbation-research.md`](../../docs/cause-copd-exacerbation-research.md) | No new orgs; drafts CE null; complementary to Wave DX (no inhaler/PEN duplicate); cross-link pneumonia (no childhood oxygen) + air-quality (no HAP CE) + alcohol-tobacco (no MPOWER); no medical dosing |
| 65 | **Visceral leishmaniasis (kala-azar)** | WHO (leishmaniasis fact sheet; SE Asia elimination; EA 2024 framework; GHO; NTD road map); GiveWell — **no** dedicated VL CEA / Top Charity (**honest null**); IHME/GBD | [`docs/cause-visceral-leishmaniasis-research.md`](../../docs/cause-visceral-leishmaniasis-research.md) | No new orgs (no DNDi/MSF/Gilead; do not expand Sightsavers); drafts CE null; complementary to skin-NTD (VL ≠ CL); cross-link deworming + LF/oncho + schisto; no medical dosing |
| 66 | **Leprosy (Hansen’s disease)** | WHO (fact sheet; Global Leprosy Strategy; free MDT; contact screening); GiveWell — **no** dedicated leprosy CEA (**honest null**); IHME GBD | [`docs/cause-leprosy-research.md`](../../docs/cause-leprosy-research.md) | No new orgs (no ILEP/Lepra; Sightsavers deworming-only); drafts CE null; complementary to skin-NTD (no scabies/yaws or thin leprosy-stub duplicate); cross-link noma + schisto + LF/oncho; no medical dosing |
| 67 | **Buruli ulcer (*Mycobacterium ulcerans*)** | WHO (fact sheet ≥33 countries; early detection + antibiotics cornerstone; GHO; skin-NTD framework); GiveWell — **no** dedicated Buruli CEA (**honest null**); IHME/GBD | [`docs/cause-buruli-ulcer-research.md`](../../docs/cause-buruli-ulcer-research.md) | No new orgs (no ALM/Anesvad/Raoul Follereau/FIND; Sightsavers deworming-only); drafts CE null; complementary to skin-NTD (no scabies/yaws or thin Buruli-bundle stub duplicate); cross-link leprosy + noma + LF/oncho; no medical dosing |
| 68 | **Human African trypanosomiasis (HAT / sleeping sickness)** | WHO (HAT fact sheet; GHO; NTD road map; EOT verification; Chagas disambiguation); GiveWell — **no** dedicated HAT CEA / Top Charity (**honest null**); IHME/GBD | [`docs/cause-hat-research.md`](../../docs/cause-hat-research.md) | No new orgs (no DNDi/MSF/FIND; do not expand Sightsavers); drafts CE null; Wave FC owns Chagas (*T. cruzi* ≠ *T. brucei*; cross-link only); complementary to VL (sandfly ≠ tsetse); cross-link LF/oncho + schisto + skin-NTD + leprosy + deworming; no medical dosing |
| 69 | **Chagas disease (American trypanosomiasis)** | WHO (fact sheet ~8M infected; >10k deaths/yr; vector/congenital/blood screening; NTD road map); GiveWell — **no** dedicated Chagas CEA (**honest null**); IHME/GBD | [`docs/cause-chagas-research.md`](../../docs/cause-chagas-research.md) | No new orgs (no DNDi/MSF/Mundo Sano; Sightsavers deworming-only); drafts CE null; complementary to VL (Chagas ≠ VL) + LF/schisto/skin-NTD/leprosy; cardiac sequelae cross-link RHD/IHD (≠ RHD ≠ IHD); no medical dosing |
| 70 | **Postpartum hemorrhage (PPH) care systems** | GiveWell — **no** dedicated PPH CEA (**honest null** beyond facility MNH uterotonic component cites — maternal owns); WHO consolidated PPH guidelines Oct 2025 + news | [`docs/cause-pph-research.md`](../../docs/cause-pph-research.md) | No new orgs (no Jhpiego/FIGO/blood services); drafts CE null; complementary to maternal (no oxytocin/misoprostol CE duplicate) + fistula (no EmONC CE duplicate); no medical dosing |
| 71 | **Preeclampsia / eclampsia care systems** | GiveWell — **no** dedicated PE/E / MgSO₄ CEA (**honest null** beyond facility MNH PE/E + MgSO₄ component cites — maternal owns); WHO PE/E recommendations 2011+ | [`docs/cause-preeclampsia-research.md`](../../docs/cause-preeclampsia-research.md) | No new orgs (no Jhpiego/FIGO/Concept Foundation/MgSO₄ manufacturers); drafts CE null; complementary to maternal (no EmONC/MgSO₄ CE duplicate) + PPH (≠ HDP) + fistula (≠ PE/E) + HTN CVD (pregnancy HDP ≠ adult salt-sub); no medical dosing |
| 72 | **Preterm birth / ACS care systems** | GiveWell — **no** dedicated ACS / preterm-birth CEA (**honest null** beyond facility MNH threatened-preterm component cites — maternal owns; KMC live maternal); WHO ACS recommendations 2022 + preterm fact sheet | [`docs/cause-preterm-birth-research.md`](../../docs/cause-preterm-birth-research.md) | No new orgs (no Jhpiego Threatened Preterm Birth Care/UNICEF/FIGO/ACS manufacturers); drafts CE null; complementary to maternal (no EmONC/ACS/KMC CE duplicate) + neonatal sepsis (≠ ACS) + PPH + preeclampsia + obstructed labor; cross-link Wave FL stillbirth (≠ ACS); no medical dosing |
| 73 | **Neonatal sepsis / SBI care systems** | GiveWell — **no** dedicated PSBI/neonatal-sepsis treatment CEA (**honest null**); CHX cord care **cite-only** (preliminary cells quarantine); WHO SBI 2024 + PSBI referral-not-feasible | [`docs/cause-neonatal-sepsis-research.md`](../../docs/cause-neonatal-sepsis-research.md) | No new orgs (no PATH CHX/UNICEF/Jhpiego); drafts CE null; complementary to maternal (no EmONC CE duplicate) + pneumonia (no childhood amox/iCCM/oxygen CE duplicate); cross-link meningitis + syphilis; no medical dosing |
| 74 | **Stillbirth / perinatal mortality prevention systems** | GiveWell — **no** dedicated stillbirth / MPDSR CEA (**honest null** beyond facility/community/PLA stillbirth outcome cites — maternal owns; syphilis pathway stays syphilis); WHO stillbirth + ENAP + MPDSR / ICD-PM / Labour Care Guide | [`docs/cause-stillbirth-research.md`](../../docs/cause-stillbirth-research.md) | No new orgs (no Jhpiego/FIGO/ICM/UNICEF stillbirth/Laerdal); drafts CE null; complementary to maternal (no EmONC/package stillbirth CE duplicate) + PPH + PE + neonatal sepsis + fistula + OL + syphilis; no medical dosing |
| 75 | **Obstructed labor / EmONC referral systems** | GiveWell — **no** dedicated OL / C-section CEA (**honest null** beyond facility MNH EmONC/labor-monitoring component cites — maternal owns; fistula prevention context — Wave DJ owns surgical quarantine); WHO EmONC handbook + prolonged/obstructed labour module | [`docs/cause-obstructed-labor-research.md`](../../docs/cause-obstructed-labor-research.md) | No new orgs (no Jhpiego/FIGO/UNFPA EmONC/AMDD); drafts CE null; complementary to maternal (no EmONC CE duplicate) + fistula (no surgical-repair CE move) + PPH (no blood-bank duplicate) + preeclampsia (no MgSO₄ duplicate); no medical/surgical how-to |
| 76 | **Cutaneous leishmaniasis (CL)** | WHO (leishmaniasis fact sheet — CL most common; ~600k–1M new cases/yr; scars/stigma; GHO; skin-NTD framework); GiveWell — **no** dedicated CL CEA / Top Charity (**honest null**); IHME/GBD | [`docs/cause-cutaneous-leishmaniasis-research.md`](../../docs/cause-cutaneous-leishmaniasis-research.md) | No new orgs (no DNDi/MSF; Sightsavers deworming-only); drafts CE null; complementary to skin-NTD (no scabies/yaws or thin Buruli/CL/mycetoma stub duplicate) + VL (**VL ≠ CL**) + Buruli + leprosy; no medical dosing |
| 77 | **Mycetoma (Madura foot)** | WHO (mycetoma fact sheet — global burden unknown; Mycetoma belt; early detection; actinomycetoma vs eumycetoma programme shape; supporting-endemic-countries; skin-NTD framework); GiveWell — **no** dedicated mycetoma CEA / Top Charity (**honest null**); IHME/GBD | [`docs/cause-mycetoma-research.md`](../../docs/cause-mycetoma-research.md) | No new orgs (no MRC/DNDi; Sightsavers deworming-only); drafts CE null; complementary to skin-NTD (no scabies/yaws or thin Buruli/CL/mycetoma stub duplicate) + Buruli + CL + leprosy; no medical dosing |
| 78 | **Yaws (*T. pallidum* subsp. *pertenue*)** | WHO (yaws fact sheet — ~15 endemic countries; ~75–80% children <15; Morges TCT + surveillance; eradication criteria; skin-NTD framework); GiveWell — **no** dedicated yaws CEA / Top Charity (**honest null**); IHME/GBD | [`docs/cause-yaws-research.md`](../../docs/cause-yaws-research.md) | No new orgs (no EMS/yaws NGOs; Sightsavers deworming-only); drafts CE null; complementary to skin-NTD (keep thin `int_skin_ntd_yaws_azithromycin_morges`; no dual CE) + Buruli + CL + leprosy; cross-link Wave FP mycetoma; no medical dosing |
| 79 | **Scabies (*Sarcoptes scabiei*)** | WHO (scabies fact sheet ≥200M; MDA ≥10%; UHC targets; crusted/outbreak; skin-NTD framework); GiveWell — Sep 2021 MDA **cite-only** (CEA cells Wave CS; below-bar) + systems **honest null**; IHME GBD | [`docs/cause-scabies-research.md`](../../docs/cause-scabies-research.md) | No new orgs (no WSEP; Sightsavers deworming-only); drafts CE null; complementary to skin-NTD (keep thin `int_skin_ntd_scabies_ivermectin_mda`; **no dual CE**) + yaws + Buruli + CL + leprosy + mycetoma; no medical dosing |
| 80 | **Acute rheumatic fever (ARF) primary prevention** | WHO (RHD fact sheet — prompt strep-throat Rx; living/housing; late diagnosis; 2024 guideline; WHA71.14); GiveWell — **no** dedicated ARF primary-prevention CEA (**honest null**); IHME/GBD | [`docs/cause-rheumatic-fever-research.md`](../../docs/cause-rheumatic-fever-research.md) | No new orgs (no WHF/Reach/school-health NGOs/BPG manufacturers); drafts CE null; complementary to Wave DM RHD (keep secondary/thin GAS/valve; **no dual CE**); cross-link IHD + CHD; Ho Hum may fold under RHD; no medical dosing |
| 81 | **Postpartum sepsis / maternal infection IPC systems** | GiveWell — **no** dedicated postpartum-sepsis / maternal-sepsis CEA (**honest null** beyond facility MNH infection-prevention component cites — maternal owns); WHO peripartum infections 2015 + Statement on Maternal Sepsis + APT-Sepsis Nov 2025 | [`docs/cause-postpartum-sepsis-research.md`](../../docs/cause-postpartum-sepsis-research.md) | No new orgs (no Jhpiego/FIGO/HRP partners/manufacturers); drafts CE null; complementary to maternal (no EmONC CE duplicate) + PPH + neonatal sepsis + syphilis; no medical dosing |
| 82 | **Thalassaemia / haemoglobinopathy systems** | WHO (EB118/5 + EB118.R1; SEARO 2021 thalassaemia + safe blood; blood-safety fact sheet); GiveWell — **no** dedicated thalassaemia CEA / Top Charity (**honest null**); IHME/GBD | [`docs/cause-thalassemia-research.md`](../../docs/cause-thalassemia-research.md) | No new orgs (no TIF/blood NGOs/chelator manufacturers); drafts CE null; complementary to sickle (no dual CE with SCD NBS/transfusion) + anaemia (iron stays nutrition) + childhood cancer + CHD (CCHD ≠ Hb-NBS); no medical dosing / chelation recipes |
| 83 | **Schisto morbidity / FGS / FSAC systems** | WHO (genital-manifestations ~56M FGS; Pocket Atlas; simultaneous-screening; fact sheet WASH/snail pillars); GiveWell — dated schisto MDA **cite-only** (Wave ER) + FGS/FSAC systems **honest null**; IHME GBD | [`docs/cause-schisto-morbidity-research.md`](../../docs/cause-schisto-morbidity-research.md) | No new orgs (no Merck/END Fund/FIG; Sightsavers deworming-only); drafts CE null; complementary to Wave ER schisto (no dual CE) + water (chlorination ≠ snail/WASH) + HIV/syphilis/cervical; no medical dosing / lesion how-to |
| 84 | **Hepatitis C (HCV) treatment-access / DAA scale-up** | WHO (HepC fact sheet; Global hepatitis report 2026; 2017 testing + 2018 care/treatment; dated access progress); GiveWell — **no** dedicated HCV DAA CEA / Top Charity (**honest null**); IHME/GBD | [`docs/cause-hepatitis-c-research.md`](../../docs/cause-hepatitis-c-research.md) | No new orgs (no CHAI/Unitaid/MPP); drafts CE null; complementary to Wave DC hepatitis (no dual CE with HepB-BD / testing-treatment / blood-safety) + cirrhosis (no DAA re-home) + HIV co-infection notes; no medical dosing / DAA regimens as how-to |
| 85 | **Japanese encephalitis / arboviral encephalitis vaccine systems** | WHO (fact sheet; IVB campaign-then-routine; 2015 position paper); GiveWell — JE CEA **honest null**; Gavi JE portfolio bibliography (Wave BZ owns Gavi) | [`docs/cause-japanese-encephalitis-research.md`](../../docs/cause-japanese-encephalitis-research.md) | No new orgs (no Gavi/PATH/Chengdu; NI immunization-only); drafts CE null; complementary to immunization (**no dual EPI CE**) + meningitis (≠ bacterial); Wave GM dengue + Wave GQ YF + Wave GT chik/Zika complementary; no medical dosing |
| 86 | **Dengue fever / Aedes-borne systems** | WHO (fact sheet; vaccines Q&A; May 2024 position; TAK-003 PQ; GVCR/GAI); GiveWell — dengue CEA **honest null**; Gavi VIS dengue bibliography (Wave BZ owns Gavi); IHME/GBD | [`docs/cause-dengue-research.md`](../../docs/cause-dengue-research.md) | No new orgs (no Gavi/Takeda/Sanofi/Wolbachia; NI/AMF/MC stay owned elsewhere); drafts CE null; complementary to JE (**≠ dengue**) + malaria (**Anopheles ≠ Aedes**) + immunization (**no dual EPI CE**); YF/Zika/chik sibling notes only; no medical dosing / vector-engineering SOPs |
| 87 | **Rabies PEP / dog vaccination systems** | WHO (fact sheet; Zero by 30; UAR; NTD roadmap); GiveWell — rabies CEA **honest null**; IHME/GBD; Gavi PEP support bibliography (Wave BZ owns Gavi) | [`docs/cause-rabies-research.md`](../../docs/cause-rabies-research.md) | No new orgs (no Gavi/UAR/GARC; NI immunization-only; **no ACE ingest**); drafts CE null; complementary to immunization (**no dual EPI CE**; dog MDV ≠ human EPI CE) + snakebite (antivenom ≠ RIG/PEP) + animal welfare; no PEP regimen how-to |
| 88 | **Yellow fever vaccine / outbreak response systems** | WHO (fact sheet; IVB; EYE; ICG guidelines); GiveWell — YF CEA **honest null**; IHME/GBD; Gavi YF portfolio bibliography (Wave BZ owns Gavi) | [`docs/cause-yellow-fever-research.md`](../../docs/cause-yellow-fever-research.md) | No new orgs (no Gavi/UNICEF/MSF/IFRC; NI immunization-only); drafts CE null; complementary to immunization (**no dual EPI CE**) + JE (≠ YF) + dengue (owns Aedes IVM); no medical dosing |
| 89 | **Chikungunya / Zika Aedes-sibling systems** | WHO (chikungunya + Zika fact sheets; GAI); GiveWell — chik/Zika CEA **honest null**; IHME/GBD | [`docs/cause-chikungunya-zika-research.md`](../../docs/cause-chikungunya-zika-research.md) | No new orgs; drafts CE null; combined `cause_chikungunya_zika` future; complementary to dengue (owns Aedes IVM), YF (≠ chik/Zika), JE (Culex ≠ Aedes), immunization (no dual EPI CE); no medical dosing / pregnancy clinical how-to |
| 90 | **Cholera / oral cholera vaccine (OCV) systems** | WHO (fact sheet; ICG cholera stockpile; GTFCC Ending Cholera 2030); GiveWell — cholera/OCV CEA **honest null**; IHME/GBD; Gavi OCV portfolio bibliography (Wave BZ owns Gavi) | [`docs/cause-cholera-research.md`](../../docs/cause-cholera-research.md) | No new orgs (no Gavi/UNICEF/MSF/IFRC/GTFCC); drafts CE null; complementary to diarrhea (**no dual ORS/thin OCV CE**) + water (WASH) + immunization (OCV ≠ EPI CE) + YF (sibling ICG); no medical dosing |
| 91 | **Typhoid / typhoid conjugate vaccine (TCV) systems** | WHO (fact sheet; IVB; position papers); GiveWell — typhoid/TCV CEA **honest null**; IHME/GBD; Gavi TCV bibliography (Wave BZ owns Gavi) | [`docs/cause-typhoid-research.md`](../../docs/cause-typhoid-research.md) | No new orgs (no Gavi/UNICEF/TyVAC); drafts CE null; complementary to diarrhea (**ORS/zinc ≠ TCV**) + cholera (**OCV ≠ TCV**) + immunization (**no dual EPI CE**) + water (WASH); no medical dosing |
| 92 | **Measles SIAs / outbreak response systems** | WHO (fact sheet; MRSF; SIA field guide; GMRLN; 2024/2025 burden news); GiveWell — measles-SIA Top Charity **honest null** (SIA intervention report cross-link/quarantine); IHME/GBD; Gavi measles/MR portfolio bibliography (Wave BZ owns Gavi) | [`docs/cause-measles-research.md`](../../docs/cause-measles-research.md) | No new orgs (no Gavi/UNICEF/M&RP; NI immunization-only); drafts CE null; complementary to immunization (**no dual EPI CE**; thin measles-SIA draft stays immunization); meningitis ≠ measles; no medical dosing |
| 93 | **Polio / nOPV / cVDPV systems** | WHO (fact sheet; strategy 2022–2026; nOPV2 PQ news; transition); GiveWell — polio Top Charity / CEA **honest null** (2016 vaccines blog incomplete-CEA cross-link/quarantine); IHME/GBD; Gavi IPV + GPEI strategy/GPLN bibliography (Wave BZ owns Gavi) | [`docs/cause-polio-research.md`](../../docs/cause-polio-research.md) | No new orgs (no Gavi/UNICEF/Rotary/GPEI; NI immunization-only); drafts CE null; complementary to immunization (**no dual EPI CE**; IPV-in-RI stay immunization); measles sibling SIA ≠ polio; no medical dosing |
| 94 | **Rotavirus vaccine (RVV) systems** | WHO (fact sheet; IVB; July 2021 position paper); GiveWell — dedicated RVV CEA / Top Charity **honest null** (NI rotavirus indirect cells stay Wave BZ); IHME/GBD; Gavi rotavirus portfolio bibliography (Wave BZ owns Gavi) | [`docs/cause-rotavirus-research.md`](../../docs/cause-rotavirus-research.md) | No new orgs (no Gavi/UNICEF/PATH/manufacturers; NI immunization-only); drafts CE null; complementary to diarrhea (**ORS/zinc ≠ RVV**) + immunization (**no dual EPI CE**) + cholera/typhoid enteric siblings; water WASH cross-link; no medical dosing / clinical rehydration how-to |
| 95 | **Hib conjugate vaccine systems** | WHO (position paper WER 2013; IVB; standardization); GiveWell — dedicated Hib Top Charity / CEA **honest null** (NI Penta/Hib stays immunization); IHME/GBD; Gavi pentavalent bibliography (Wave BZ owns Gavi) | [`docs/cause-hib-research.md`](../../docs/cause-hib-research.md) | No new orgs (no Gavi/Hib Initiative; NI immunization-only); drafts CE null; complementary to immunization (**no dual EPI CE**); **Hib ≠ PCV** (pneumonia case management stays Wave DB); meningitis MenA ≠ Hib; measles/polio SIAs ≠ Hib intro; no medical dosing |
| 96 | **Rubella / CRS systems** | WHO (fact sheet; position paper; SAGE; CRS VPD; MRSF); GiveWell — rubella/CRS Top Charity / CEA **honest null**; IHME/GBD; Gavi measles/MR bibliography (Wave BZ owns Gavi) | [`docs/cause-rubella-research.md`](../../docs/cause-rubella-research.md) | No new orgs; drafts CE null; complementary to immunization (**no dual EPI CE**) + measles (**rubella ≠ measles SIAs**); no medical dosing |
| 97 | **PCV / pneumococcal conjugate vaccine systems** | WHO (Sep 2025/2019 position paper; IVB; standardization); GiveWell — dedicated PCV Top Charity / CEA **honest null** (NI PCV stays immunization); IHME/GBD; Gavi pneumococcal bibliography (Wave BZ owns Gavi) | [`docs/cause-pcv-research.md`](../../docs/cause-pcv-research.md) | No new orgs (no Gavi/PATH/manufacturers; NI immunization-only); drafts CE null; complementary to immunization (**no dual EPI CE**); **PCV ≠ care** (Wave DB); **Hib ≠ PCV**; meningitis MenA ≠ PCV; no medical dosing |
| 98 | **HPV vaccine introduction / catch-up / vaccination-pillar systems** | WHO (Dec 2022 position paper; IVB; product-choice; single-dose news; elimination 90% vaccination pillar); GiveWell — **no** HPV Top Charity; Oct 2020 HPV report stays immunization cross-link; delivery-systems CEA **honest null**; IHME/GBD; Gavi HPV bibliography (Wave BZ owns Gavi) | [`docs/cause-hpv-research.md`](../../docs/cause-hpv-research.md) | No new orgs (no Gavi/PATH/CHAI/Jhpiego; NI immunization-only); drafts CE null; complementary to immunization (**no dual CE**; thin `int_immunization_hpv` stays immunization); **HPV vaccine ≠ screening CE** (Wave CX); rubella ≠ HPV; no medical dosing |
| 99 | **Maternal / neonatal tetanus (MNT) elimination systems** | WHO (MNTE strategies/progress/programmatic update; tetanus fact sheet; WER9206; Protecting-all); GiveWell — **no** MNT Top Charity (**honest null**); intervention report + rough CEA + UNICEF MNTE declined-review = cite-only/quarantine; IHME/GBD; Gavi TTCV adjacency bibliography (Wave BZ owns Gavi) | [`docs/cause-maternal-neonatal-tetanus-research.md`](../../docs/cause-maternal-neonatal-tetanus-research.md) | No new orgs (no UNICEF/Kiwanis/Gavi; NI immunization-only); drafts CE null; complementary to immunization (**no dual routine Td/TT EPI CE**) + maternal (**no dual EmONC CE**); neonatal sepsis sibling adjacency (CHX stays FI); no medical dosing |
| 99 | **MenA / meningococcal conjugate vaccine systems** | WHO (fact sheet; Jan 2024 MMCV belt position paper; Defeating Meningitis); GiveWell — dedicated MenA Top Charity / completed CEA **honest null** (Jan 2016 RFMF-stop cite-only); IHME/GBD; Gavi meningococcal bibliography (Wave BZ owns Gavi) | [`docs/cause-meningococcal-research.md`](../../docs/cause-meningococcal-research.md) | No new orgs (no Gavi/MVP/ICG/PATH/manufacturers; NI immunization-only); drafts CE null; complementary to meningitis (**belt/care/sequelae stay Wave DU**; **no dual CE**) + immunization (**no dual EPI CE**); **Hib ≠ MenA**; **PCV ≠ MenA**; no medical dosing |
| 100 | **Malaria SMC / seasonal chemoprevention systems** | WHO (fact sheet; guidelines for malaria; SMC field guide 2nd ed.; WMR 2024); GiveWell — Malaria Consortium SMC Top Charity **cite by reference only** (live `int_smc`; never invent draft CE); IHME/GBD | [`docs/cause-malaria-smc-research.md`](../../docs/cause-malaria-smc-research.md) | No new orgs (MC/AMF/PATH live — do not re-ingest); drafts CE null; complementary to live malaria (**no dual CE** with `int_smc`/`int_itn`; Wave BY PMC/IRS stay malaria); pneumonia/maternal adjacency; no medical dosing |
| 101 | **IPTp / malaria in pregnancy systems** | WHO (Guidelines for malaria; Jun 2022 chemoprevention; Jan 2024 c-IPTp; WMR/GHO IPTp3); GiveWell — IPTp Top Charity **honest null** (preliminary CEA quarantine); IHME/GBD | [`docs/cause-malaria-iptp-research.md`](../../docs/cause-malaria-iptp-research.md) | No new orgs (do not expand AMF/MC/PATH as IPTp); drafts CE null; complementary to malaria (**no dual ITN/SMC CE**) + Wave HT SMC (**SMC ≠ IPTp**) + maternal (**no dual EmONC CE**); no medical dosing |
| 102 | **Malaria IRS / indoor residual spray systems** | WHO (fact sheet ITNs+IRS core; guidelines co-deployment; IRS operational manual Feb 2024; IRM framework; WMR 2024); GiveWell — AMF/ITN Top Charity **cite by reference only** (live `int_itn`; IRS Top Charity **honest null**); IHME/GBD | [`docs/cause-malaria-irs-research.md`](../../docs/cause-malaria-irs-research.md) | No new orgs (AMF/MC/PATH live — do not re-ingest; no IRS implementer); drafts CE null; complementary to live malaria (**no dual CE** with `int_itn`/`int_smc`; Wave BY thin `int_malaria_irs` stay malaria); HT SMC ≠ IRS; HV IPTp ≠ IRS; no pesticide how-to |
| 103 | **PMC / perennial malaria chemoprevention systems** | WHO (Guidelines for malaria; Jun 2022 chemoprevention — IPTi→PMC; fact sheet; WMR); GiveWell — PMC Top Charity **honest null** (PATH DRC pilot grant CEA quarantine); IHME/GBD | [`docs/cause-malaria-pmc-research.md`](../../docs/cause-malaria-pmc-research.md) | No new orgs (do not expand AMF/MC/PATH as PMC Top Charity; `org_path` cite-only); drafts CE null; complementary to malaria (**no dual ITN/SMC CE**; Wave BY thin PMC stay malaria) + Wave HT SMC (**SMC ≠ PMC**) + Wave HV IPTp (**IPTp ≠ PMC**) + Wave IA IRS (**IRS ≠ PMC**); no medical dosing |
| 104 | **Malaria vaccine introduction / RTS,S / R21 systems** | WHO (fact sheet RTS,S/R21; Q&A; R21 Oct 2023; GMP vaccines hub; WMR); GiveWell — malaria-vaccine Top Charity **honest null** (PATH TA cite-only; thin TA $/life null); IHME/GBD; Gavi malaria support bibliography (Wave BZ owns Gavi) | [`docs/cause-malaria-vaccine-research.md`](../../docs/cause-malaria-vaccine-research.md) | No new orgs (PATH/AMF/MC live — do not re-ingest; no Gavi/manufacturers); drafts CE null; complementary to malaria (**no dual ITN/SMC CE**; thin vaccine TA stay malaria) + Wave HT SMC (**SMC ≠ vaccine**) + Wave HV IPTp (**IPTp ≠ vaccine**) + Wave IA IRS (**IRS ≠ vaccine**) + Wave IB PMC (**PMC ≠ vaccine**) + Wave BZ immunization (**no dual EPI CE**); no individual dosing how-to |
| 105 | **Varicella (chickenpox) / VZV vaccine introduction & catch-up systems** | WHO (Nov 2025 position paper; June 2014 historical; IVB; VPD varicella surveillance; intro principles); GiveWell — varicella Top Charity / systems CEA **honest null**; IHME/GBD; Gavi portfolio bibliography — varicella **not listed** (Wave BZ owns Gavi) | [`docs/cause-varicella-research.md`](../../docs/cause-varicella-research.md) | No new orgs (no Gavi/UNICEF/manufacturers; NI immunization-only); drafts CE null; complementary to immunization (**no dual EPI CE**); **measles ≠ varicella**; **rubella/CRS ≠ varicella**; MMRV bibliography only; zoster ≠ childhood varicella; no medical dosing |
| 106 | **Malaria LSM / larval source management systems** | WHO (fact sheet ITNs+IRS core; guidelines conditional larviciding few/fixed/findable; habitat mod/manip no recommendation; LSM operational manual Anopheles+Aedes; WMR 2024); GiveWell — AMF/ITN Top Charity **cite by reference only** (live `int_itn`; LSM Top Charity / dedicated CEA **honest null**); IHME/GBD | [`docs/cause-malaria-lsm-research.md`](../../docs/cause-malaria-lsm-research.md) | No new orgs (AMF/MC/PATH live — do not re-ingest; no LSM implementer); drafts CE null; complementary to live malaria (**no dual CE** with `int_itn`/`int_smc`); IA IRS ≠ LSM; HT SMC ≠ LSM; HV IPTp ≠ LSM; IB PMC ≠ LSM; IC vaccine ≠ LSM; dengue Aedes ≠ Anopheles LSM ownership; no pesticide / breeding-site how-to |
| 107 | **Hepatitis A (HAV) vaccine introduction / catch-up / outbreak systems** | WHO (Oct 2022 position paper; fact sheet; outbreak toolbox; VPD HepA; intro principles); GiveWell — HepA Top Charity / systems CEA **honest null**; IHME/GBD; Gavi portfolio bibliography — HepA **not listed** (VIS 2018 deprioritised; Wave BZ owns Gavi) | [`docs/cause-hepatitis-a-research.md`](../../docs/cause-hepatitis-a-research.md) | No new orgs (no Gavi/UNICEF/manufacturers; NI immunization-only); drafts CE null; complementary to immunization (**no dual EPI CE**); **HepB ≠ HepA**; **HepC ≠ HepA**; WASH CE stays water; ORS ≠ HepA vaccine; HepE ≠ HepA; no medical dosing |
| 108 | **Mumps vaccine introduction / catch-up / outbreak response systems** | WHO (March 2024 position paper; IVB; VPD mumps surveillance; intro principles); GiveWell — mumps Top Charity / systems CEA **honest null**; IHME/GBD; Gavi portfolio bibliography — mumps/MMR **not listed** (measles/MR ≠ MMR; Wave BZ owns Gavi) | [`docs/cause-mumps-research.md`](../../docs/cause-mumps-research.md) | No new orgs (no Gavi/UNICEF/manufacturers; NI immunization-only); drafts CE null; complementary to immunization (**no dual EPI CE**); **measles ≠ mumps**; **rubella/CRS ≠ mumps**; **varicella ≠ mumps**; MMR/MMRV bibliography only; no medical dosing / orchitis clinical how-to |
| 109 | **Seasonal influenza vaccine / programme systems** | WHO (May 2022 influenza vaccines position paper / SAGE; Global Influenza Strategy 2019–2030; toolkit; 2023 policy brief; GISRS); GiveWell — seasonal influenza Top Charity / systems CEA **honest null**; IHME/GBD influenza-associated LRI bibliography; Gavi portfolio bibliography — seasonal flu **not** current listed window (Wave BZ owns Gavi) | [`docs/cause-influenza-research.md`](../../docs/cause-influenza-research.md) | No new orgs (no Gavi/UNICEF/manufacturers; NI immunization-only); drafts CE null; complementary to immunization (**no dual EPI CE**); **seasonal ≠ pandemic** (Wave CT); **pneumonia care ≠ flu vaccine**; SMC ≠ influenza vaccine; no medical dosing; no strain-engineering / dual-use how-to |
| 110 | **Malaria case management / diagnosis systems** | WHO (fact sheet; guidelines; GMP case-management / diagnosis / RDT / microscopy / treatment hubs; pre-referral RAS field guide bibliography; WMR 2024); GiveWell — AMF/ITN + MC/SMC Top Charity **cite by reference only** (live `int_itn`/`int_smc`; CM Top Charity / dedicated published CM CEA **honest null**; iCCM interim quarantine); IHME/GBD | [`docs/cause-malaria-case-management-research.md`](../../docs/cause-malaria-case-management-research.md) | No new orgs (AMF/MC/PATH live — do not re-ingest; no CHAI/RDT manufacturer ingest); drafts CE null; complementary to live malaria (**no dual CE** with `int_itn`/`int_smc`); HT SMC ≠ CM; HV IPTp ≠ CM; IA IRS ≠ CM; IB PMC ≠ CM; IC vaccine ≠ CM; IG LSM ≠ CM; pneumonia care ≠ malaria CM CE (iCCM cross-link only); no clinical dosing |
| 119 | **IPTi / intermittent preventive treatment in infants systems** | WHO (Guidelines for malaria; Jun 2022 chemoprevention — IPTi→PMC; fact sheet; WMR); GiveWell — IPTi Top Charity **honest null** (interim preliminary CEA quarantine; PATH PMC pilot CEA IB primary); IHME/GBD | [`docs/cause-malaria-ipti-research.md`](../../docs/cause-malaria-ipti-research.md) | No new orgs (AMF/MC/PATH live — cite-only); drafts CE null; complementary to live malaria (**no dual CE**); Wave IB PMC sibling (no dual CE); HT SMC ≠ IPTi; HV IPTp ≠ IPTi; IN CM ≠ prevention; immunization EPI adjacency; no medical dosing |
| 120 | **Malaria MDA / mass screening-and-treatment programme systems** | WHO (fact sheet; guidelines MDA family; elimination recommendations; role-of-MDA/MSAT note; WMR 2024); GiveWell — AMF/ITN + MC/SMC Top Charity **cite by reference only** (live `int_itn`/`int_smc`; MDA Top Charity / dedicated published MDA CEA **honest null**); IHME/GBD | [`docs/cause-malaria-mda-research.md`](../../docs/cause-malaria-mda-research.md) | No new orgs (AMF/MC/PATH live — do not re-ingest; no MDA implementer); drafts CE null; complementary to live malaria (**no dual CE** with `int_itn`/`int_smc`); HT SMC ≠ MDA; HV IPTp ≠ MDA; IB PMC ≠ MDA; IR IPTi ≠ MDA; IN CM ≠ MDA; no medical dosing |
| 121 | **Malaria IPTsc / school-age chemoprevention systems** | WHO (fact sheet; guidelines IPTsc family; Jun 2022 chemoprevention/elimination news; preventive-chemotherapies hub; WMR 2024); GiveWell — AMF/ITN + MC/SMC Top Charity **cite by reference only** (live `int_itn`/`int_smc`; IPTsc Top Charity / dedicated published IPTsc CEA **honest null**; May 2026 searching-blog RFP/pilot cite-only); IHME/GBD | [`docs/cause-malaria-iptsc-research.md`](../../docs/cause-malaria-iptsc-research.md) | No new orgs (AMF/MC/PATH live — do not re-ingest; no IPTsc implementer); drafts CE null; complementary to live malaria (**no dual CE** with `int_itn`/`int_smc`); HT SMC ≠ IPTsc; HV IPTp ≠ IPTsc; IB PMC ≠ IPTsc; IR IPTi ≠ IPTsc; IU MDA ≠ IPTsc; IN CM ≠ prevention; no medical dosing |
| 110 | **Hepatitis E vaccine / outbreak-response programme systems** | WHO/SAGE (May 2015 position; March 2024 SAGE FCV WCBA; fact sheet; outbreak toolbox; 2014 waterborne report); GiveWell — HepE Top Charity / systems CEA **honest null**; IHME/GBD; Gavi VIS 2024 HepE stockpile bibliography (Wave BZ owns Gavi) | [`docs/cause-hepatitis-e-research.md`](../../docs/cause-hepatitis-e-research.md) | No new orgs (no Gavi/UNICEF/MSF/BMGF/manufacturers; NI immunization-only); drafts CE null; complementary to immunization (**no dual EPI CE**); **HepA ≠ HepE**; **HepB ≠ HepE**; **HepC ≠ HepE**; WASH CE stays water; ORS ≠ HepE vaccine; cholera OCV/ICG ≠ HepE; no medical dosing |
| 123 | **Hepatitis D / HDV co-infection programme systems** | WHO (HepD fact sheet; 2024 CHB guidelines HDV who/how/reflex; Global hepatitis report 2024); GiveWell — HepD Top Charity / systems CEA **honest null**; HLI/ACE honest null; IHME/GBD | [`docs/cause-hepatitis-d-research.md`](../../docs/cause-hepatitis-d-research.md) | No new orgs (no CHAI/Unitaid/Global Fund hepatitis/diagnostics/antiviral manufacturers; NI immunization-only); drafts CE null; complementary to HepB (**HepB ≠ HepD**; birth-dose CE stays HN); **HepC ≠ HepD**; **HepA ≠ HepD**; **HepE ≠ HepD**; immunization (**no dual EPI CE**); no medical dosing |
| 112 | **Diphtheria vaccine / antitoxin programme systems** | WHO/SAGE (fact sheet; Aug 2017 WER9231; IVB; AFRO Feb 2024 outbreak guidance; VPD standards; DAT access/stockpile programme framing); GiveWell — diphtheria Top Charity / systems CEA **honest null** (NI Penta incidental Wave BZ); IHME/GBD; Gavi pentavalent/DTP-booster/hexavalent bibliography (Wave BZ owns Gavi) | [`docs/cause-diphtheria-research.md`](../../docs/cause-diphtheria-research.md) | No new orgs (no Gavi/UNICEF/MSF/DAT manufacturers; NI immunization-only); drafts CE null; complementary to immunization (**no dual EPI CE**; DTP–Penta stays immunization); **MNT ≠ diphtheria toxoid programmes**; **pertussis ≠ diphtheria**; **Hib ≠ diphtheria systems**; no medical dosing / antitoxin reconstitution |
| 120 | **Childhood / adolescent / adult tetanus toxoid booster systems (beyond MNT)** | WHO/SAGE (fact sheet; Feb 2017 WER9206; Protecting-all; IVB; MNTE strategies sustain); GiveWell — childhood-tetanus Top Charity / systems CEA **honest null** (NI Penta incidental Wave BZ; MNT report Wave HR quarantine); IHME/GBD; Gavi DTP-booster/pentavalent bibliography (Wave BZ owns Gavi) | [`docs/cause-tetanus-childhood-research.md`](../../docs/cause-tetanus-childhood-research.md) | No new orgs (no Gavi/UNICEF/manufacturers; NI immunization-only); drafts CE null; complementary to MNT (**MNT ≠ childhood/adolescent/adult boosters**) + immunization (**no dual EPI CE**; DTP–Penta stays immunization); **pertussis ≠ tetanus boosters**; **diphtheria ≠ tetanus childhood boosters**; no medical dosing / wound-care how-to |
| 111 | **Pertussis (whooping cough) vaccine / outbreak systems** | WHO/SAGE (health topic; WER9035; SAGE WG/ToR; IVB; GHO DTP3/cases); GiveWell — pertussis Top Charity / systems CEA **honest null** (NI Penta incidental Wave BZ); IHME/GBD; Gavi pentavalent/hexavalent/DTP-booster bibliography (Wave BZ owns Gavi) | [`docs/cause-pertussis-research.md`](../../docs/cause-pertussis-research.md) | No new orgs (no Gavi/UNICEF/manufacturers; NI immunization-only); drafts CE null; complementary to immunization (**no dual EPI CE**; DTP–Penta stays immunization); **MNT ≠ aP/wP**; **Hib ≠ pertussis**; **PCV/pneumonia care ≠ pertussis vaccine**; no medical dosing |

**Wave GG (folded into 0.2.14):** Schisto morbidity / FGS / FSAC systems research pack — [`docs/cause-schisto-morbidity-research.md`](../../docs/cause-schisto-morbidity-research.md) · future `cause_schisto_morbidity` (complementary to Wave ER MDA/PC ownership; CE null drafts; no dual CE).

**Wave GI / GK / GM / GN / GQ / GT / GV (folded into 0.2.15):** hepatitis C DAA · JE · dengue · rabies · yellow fever · chikungunya/Zika · cholera/OCV — each CE null; ADR 0007 **Proposed**.

**Wave GW (Unreleased post-0.2.15; QA pass landed):** Typhoid / TCV systems — [`docs/cause-typhoid-research.md`](../../docs/cause-typhoid-research.md) · future `cause_typhoid` (row **91**; live disk **92**).

**Wave GX (Unreleased post-0.2.15):** Outcomes list/get API adversarial — `outcomes_adversarial` (**30**/30); live CI **47/47** vs freeze **46/46**.

**Wave GY (Unreleased post-0.2.15; QA pass landed):** Measles SIAs / outbreak response — [`docs/cause-measles-research.md`](../../docs/cause-measles-research.md) · future `cause_measles` (row **92**; live disk **92**).

**Wave HA (docs):** agent-facing surfaces synced to **0.2.15** (no bump). Freeze **90** / live **92**; CI freeze **46/46** / live **47/47**; ADR 0007 **Proposed**; `mixes_units_in_ranking: false`.

**Wave HK (Unreleased post-0.2.15; QA pass landed):** PCV / pneumococcal conjugate vaccine systems — [`docs/cause-pcv-research.md`](../../docs/cause-pcv-research.md) · future `cause_pcv` (row **97**; live disk **97**).



**Wave HT (Unreleased post-0.2.15; QA pass landed):** Malaria SMC / seasonal chemoprevention systems — [`docs/cause-malaria-smc-research.md`](../../docs/cause-malaria-smc-research.md) · future `cause_malaria_smc` (row **100**; live disk **102**).
**Wave HP (Unreleased post-0.2.15; QA pass landed):** MenA / meningococcal conjugate vaccine systems — [`docs/cause-meningococcal-research.md`](../../docs/cause-meningococcal-research.md) · future `cause_meningococcal` (row **99**; live disk **102**).
**Wave HL (Unreleased post-0.2.15; QA pass landed):** HPV vaccine introduction / catch-up / vaccination-pillar systems — [`docs/cause-hpv-research.md`](../../docs/cause-hpv-research.md) · future `cause_hpv` (row **98**; live disk **98**).

**Wave HR (Unreleased post-0.2.15; QA pass landed):** Maternal / neonatal tetanus (MNT) elimination systems — [`docs/cause-maternal-neonatal-tetanus-research.md`](../../docs/cause-maternal-neonatal-tetanus-research.md) · future `cause_maternal_neonatal_tetanus` (row **99**; live disk **102**).

**Wave HG (Unreleased post-0.2.15; QA pass landed):** Rubella / CRS systems — [`docs/cause-rubella-research.md`](../../docs/cause-rubella-research.md) · future `cause_rubella` (row **96**; live disk **96**).

**Wave GZ (Unreleased):** Polio / nOPV / cVDPV systems research pack — [`docs/cause-polio-research.md`](../../docs/cause-polio-research.md) · future `cause_polio` (complementary to Wave BZ immunization; CE null drafts; **no dual EPI CE**).

**Wave HC (Unreleased post-0.2.15; QA pass landed):** Rotavirus / RVV systems — [`docs/cause-rotavirus-research.md`](../../docs/cause-rotavirus-research.md) · future `cause_rotavirus` (row **94**; live disk **96**).

**Wave HD (Unreleased post-0.2.15; QA pass landed):** Hib conjugate vaccine systems — [`docs/cause-hib-research.md`](../../docs/cause-hib-research.md) · future `cause_hib` (row **95**; live disk **95**).
**Wave HV (Unreleased post-0.2.15; QA pass landed):** IPTp / malaria in pregnancy systems — [`docs/cause-malaria-iptp-research.md`](../../docs/cause-malaria-iptp-research.md) · future `cause_malaria_iptp` (row **101**; live disk **103**).
**Wave IA (Unreleased post-0.2.15; QA pass landed):** IRS / indoor residual spray systems — [`docs/cause-malaria-irs-research.md`](../../docs/cause-malaria-irs-research.md) · future `cause_malaria_irs` (row **102**; live disk **104**).

**Wave IB (Unreleased post-0.2.15; QA pass landed):** PMC / perennial malaria chemoprevention systems — [`docs/cause-malaria-pmc-research.md`](../../docs/cause-malaria-pmc-research.md) · future `cause_malaria_pmc` (row **103**; live disk **105**).

**Wave IC (Unreleased post-0.2.15; QA pass landed):** Malaria vaccine introduction / RTS,S / R21 systems — [`docs/cause-malaria-vaccine-research.md`](../../docs/cause-malaria-vaccine-research.md) · future `cause_malaria_vaccine` (row **104**; live disk **106**).

**Wave II (Unreleased post-0.2.15; QA pass landed):** Mumps vaccine introduction / catch-up / outbreak response systems — [`docs/cause-mumps-research.md`](../../docs/cause-mumps-research.md) · future `cause_mumps` (row **108**; live disk **111**).
**Wave IG (Unreleased post-0.2.15; QA pass landed):** Malaria LSM / larval source management systems — [`docs/cause-malaria-lsm-research.md`](../../docs/cause-malaria-lsm-research.md) · future `cause_malaria_lsm` (row **106**; live disk **109**).

**Wave IH (Unreleased post-0.2.15; QA pass landed):** Hepatitis A (HAV) vaccine introduction / catch-up / outbreak systems — [`docs/cause-hepatitis-a-research.md`](../../docs/cause-hepatitis-a-research.md) · future `cause_hepatitis_a` (row **107**; live disk **111**).
**Wave IL (Unreleased post-0.2.15; QA pass landed):** Hepatitis E vaccine / outbreak-response programme systems — [`docs/cause-hepatitis-e-research.md`](../../docs/cause-hepatitis-e-research.md) · future `cause_hepatitis_e` (row **110**; live disk **113**).
**Wave JC (Unreleased post-0.2.15; QA pass landed):** Hepatitis D / HDV co-infection programme systems — [`docs/cause-hepatitis-d-research.md`](../../docs/cause-hepatitis-d-research.md) · future `cause_hepatitis_d` (row **123**; live disk **122**).

**Wave IN (Unreleased post-0.2.15; QA pass landed):** Malaria case management / diagnosis systems — [`docs/cause-malaria-case-management-research.md`](../../docs/cause-malaria-case-management-research.md) · future `cause_malaria_case_management` (row **110**; live disk **114**).

**Wave IR (Unreleased post-0.2.15; QA pass landed):** IPTi / intermittent preventive treatment in infants systems — [`docs/cause-malaria-ipti-research.md`](../../docs/cause-malaria-ipti-research.md) · future `cause_malaria_ipti` (row **119**; live disk **117**).

**Wave IU (Unreleased post-0.2.15; QA pass landed):** Malaria MDA / mass screening-and-treatment programme systems — [`docs/cause-malaria-mda-research.md`](../../docs/cause-malaria-mda-research.md) · future `cause_malaria_mda` (row **120**; live disk **119**).
**Wave IZ (Unreleased post-0.2.15; QA pass landed):** LF MDA / transmission interruption programme systems — [`docs/cause-lf-mda-research.md`](../../docs/cause-lf-mda-research.md) · future `cause_lf_mda` (row **122**; live disk **122**).

**Wave IX (Unreleased post-0.2.15; QA pass landed):** Malaria IPTsc / school-age chemoprevention systems — [`docs/cause-malaria-iptsc-research.md`](../../docs/cause-malaria-iptsc-research.md) · future `cause_malaria_iptsc` (row **121**; live disk **121**).

**Wave IP (Unreleased post-0.2.15; QA pass landed):** Diphtheria vaccine / antitoxin programme systems — [`docs/cause-diphtheria-research.md`](../../docs/cause-diphtheria-research.md) · future `cause_diphtheria` (row **112**; live disk **117**).
**Wave IS (Unreleased post-0.2.15; QA pass landed):** Childhood / adolescent / adult tetanus toxoid booster systems beyond MNT — [`docs/cause-tetanus-childhood-research.md`](../../docs/cause-tetanus-childhood-research.md) · future `cause_tetanus_childhood` (row **120**; live disk **119**).

**Wave IK (Unreleased post-0.2.15; QA pass landed):** RSV maternal vaccine / long-acting mAb programme systems — [`docs/cause-rsv-research.md`](../../docs/cause-rsv-research.md) · future `cause_rsv` (live disk **112**).
**Wave IJ (Unreleased post-0.2.15; QA pass landed):** Seasonal influenza vaccine / programme systems — [`docs/cause-influenza-research.md`](../../docs/cause-influenza-research.md) · future `cause_influenza` (row **109**; live disk **111**).

**Wave IF (Unreleased post-0.2.15; QA pass landed):** Varicella (chickenpox) / VZV vaccine introduction & catch-up systems — [`docs/cause-varicella-research.md`](../../docs/cause-varicella-research.md) · future `cause_varicella` (row **105**; live disk **107**).